| Full name: host cell factor C2 | Alias Symbol: HCF-2 | ||
| Type: protein-coding gene | Cytoband: 12q23.3 | ||
| Entrez ID: 29915 | HGNC ID: HGNC:24972 | Ensembl Gene: ENSG00000111727 | OMIM ID: 607926 |
| Drug and gene relationship at DGIdb | |||
HCFC2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05168 | Herpes simplex infection |
Expression of HCFC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HCFC2 | 29915 | 219484_at | -0.6534 | 0.0955 | |
| GSE20347 | HCFC2 | 29915 | 219484_at | -0.5676 | 0.0001 | |
| GSE23400 | HCFC2 | 29915 | 219484_at | -0.1308 | 0.0008 | |
| GSE26886 | HCFC2 | 29915 | 219484_at | -0.7796 | 0.0059 | |
| GSE29001 | HCFC2 | 29915 | 219484_at | -0.4304 | 0.1314 | |
| GSE38129 | HCFC2 | 29915 | 219484_at | -0.5205 | 0.0000 | |
| GSE45670 | HCFC2 | 29915 | 219484_at | -0.4023 | 0.0223 | |
| GSE53622 | HCFC2 | 29915 | 16918 | -0.6524 | 0.0000 | |
| GSE53624 | HCFC2 | 29915 | 16918 | -0.5783 | 0.0000 | |
| GSE63941 | HCFC2 | 29915 | 219484_at | -1.1142 | 0.0482 | |
| GSE77861 | HCFC2 | 29915 | 219484_at | -0.4749 | 0.0342 | |
| GSE97050 | HCFC2 | 29915 | A_33_P3250018 | -0.1511 | 0.5179 | |
| SRP007169 | HCFC2 | 29915 | RNAseq | -0.8213 | 0.0148 | |
| SRP008496 | HCFC2 | 29915 | RNAseq | -0.6642 | 0.0044 | |
| SRP064894 | HCFC2 | 29915 | RNAseq | -0.5273 | 0.0334 | |
| SRP133303 | HCFC2 | 29915 | RNAseq | -0.2650 | 0.1819 | |
| SRP159526 | HCFC2 | 29915 | RNAseq | -0.8675 | 0.0008 | |
| SRP193095 | HCFC2 | 29915 | RNAseq | -0.8156 | 0.0000 | |
| SRP219564 | HCFC2 | 29915 | RNAseq | -0.6784 | 0.1263 | |
| TCGA | HCFC2 | 29915 | RNAseq | -0.3263 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by HCFC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HCFC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HCFC2 | 29915 | 4 | 2 | 24 | |
| GSE20123 | HCFC2 | 29915 | 4 | 2 | 24 | |
| GSE43470 | HCFC2 | 29915 | 2 | 0 | 41 | |
| GSE46452 | HCFC2 | 29915 | 9 | 1 | 49 | |
| GSE47630 | HCFC2 | 29915 | 9 | 1 | 30 | |
| GSE54993 | HCFC2 | 29915 | 0 | 5 | 65 | |
| GSE54994 | HCFC2 | 29915 | 4 | 2 | 47 | |
| GSE60625 | HCFC2 | 29915 | 0 | 0 | 11 | |
| GSE74703 | HCFC2 | 29915 | 2 | 0 | 34 | |
| GSE74704 | HCFC2 | 29915 | 1 | 2 | 17 | |
| TCGA | HCFC2 | 29915 | 19 | 11 | 66 |
Total number of gains: 54; Total number of losses: 26; Total Number of normals: 408.
Somatic mutations of HCFC2:
Generating mutation plots.
Highly correlated genes for HCFC2:
Showing top 20/1102 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HCFC2 | RBFA | 0.76072 | 3 | 0 | 3 |
| HCFC2 | TIAL1 | 0.746485 | 3 | 0 | 3 |
| HCFC2 | MED23 | 0.741314 | 3 | 0 | 3 |
| HCFC2 | MRFAP1L1 | 0.738708 | 3 | 0 | 3 |
| HCFC2 | BRD8 | 0.737533 | 3 | 0 | 3 |
| HCFC2 | SLC25A27 | 0.737408 | 3 | 0 | 3 |
| HCFC2 | ZNF407 | 0.731367 | 4 | 0 | 4 |
| HCFC2 | YTHDF2 | 0.730534 | 3 | 0 | 3 |
| HCFC2 | NPTN | 0.721602 | 3 | 0 | 3 |
| HCFC2 | IPMK | 0.715878 | 3 | 0 | 3 |
| HCFC2 | RBPJL | 0.714155 | 3 | 0 | 3 |
| HCFC2 | PARD3 | 0.711888 | 4 | 0 | 3 |
| HCFC2 | ARGLU1 | 0.707165 | 3 | 0 | 3 |
| HCFC2 | ZEB2 | 0.705523 | 3 | 0 | 3 |
| HCFC2 | RNPC3 | 0.705286 | 3 | 0 | 3 |
| HCFC2 | RGMB | 0.700621 | 3 | 0 | 3 |
| HCFC2 | NR1D2 | 0.69596 | 3 | 0 | 3 |
| HCFC2 | THAP1 | 0.695324 | 3 | 0 | 3 |
| HCFC2 | ARRDC3 | 0.695085 | 6 | 0 | 5 |
| HCFC2 | NCK2 | 0.690373 | 5 | 0 | 4 |
For details and further investigation, click here
