| Full name: NIMA related kinase 3 | Alias Symbol: HSPK36|MGC29949 | ||
| Type: protein-coding gene | Cytoband: 13q14.3 | ||
| Entrez ID: 4752 | HGNC ID: HGNC:7746 | Ensembl Gene: ENSG00000136098 | OMIM ID: 604044 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NEK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NEK3 | 4752 | 213116_at | -0.0169 | 0.9731 | |
| GSE20347 | NEK3 | 4752 | 213116_at | -0.0309 | 0.8639 | |
| GSE23400 | NEK3 | 4752 | 213116_at | -0.0117 | 0.8784 | |
| GSE26886 | NEK3 | 4752 | 213116_at | 0.9170 | 0.0001 | |
| GSE29001 | NEK3 | 4752 | 213116_at | 0.1172 | 0.6873 | |
| GSE38129 | NEK3 | 4752 | 213116_at | -0.0446 | 0.7773 | |
| GSE45670 | NEK3 | 4752 | 213116_at | -0.4859 | 0.0331 | |
| GSE53622 | NEK3 | 4752 | 42460 | 0.1973 | 0.0794 | |
| GSE53624 | NEK3 | 4752 | 42460 | 0.2447 | 0.0174 | |
| GSE63941 | NEK3 | 4752 | 213116_at | -1.4824 | 0.0669 | |
| GSE77861 | NEK3 | 4752 | 213116_at | 0.5594 | 0.0728 | |
| GSE97050 | NEK3 | 4752 | A_23_P333705 | 0.0010 | 0.9975 | |
| SRP007169 | NEK3 | 4752 | RNAseq | 2.1376 | 0.0212 | |
| SRP064894 | NEK3 | 4752 | RNAseq | 0.5592 | 0.0009 | |
| SRP133303 | NEK3 | 4752 | RNAseq | 0.0663 | 0.7647 | |
| SRP159526 | NEK3 | 4752 | RNAseq | -0.6952 | 0.0041 | |
| SRP193095 | NEK3 | 4752 | RNAseq | 0.2700 | 0.2427 | |
| SRP219564 | NEK3 | 4752 | RNAseq | -0.0779 | 0.7864 | |
| TCGA | NEK3 | 4752 | RNAseq | -0.1781 | 0.0594 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by NEK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NEK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NEK3 | 4752 | 1 | 13 | 16 | |
| GSE20123 | NEK3 | 4752 | 1 | 12 | 17 | |
| GSE43470 | NEK3 | 4752 | 3 | 12 | 28 | |
| GSE46452 | NEK3 | 4752 | 0 | 32 | 27 | |
| GSE47630 | NEK3 | 4752 | 2 | 27 | 11 | |
| GSE54993 | NEK3 | 4752 | 12 | 2 | 56 | |
| GSE54994 | NEK3 | 4752 | 1 | 15 | 37 | |
| GSE60625 | NEK3 | 4752 | 0 | 3 | 8 | |
| GSE74703 | NEK3 | 4752 | 3 | 10 | 23 | |
| GSE74704 | NEK3 | 4752 | 0 | 9 | 11 | |
| TCGA | NEK3 | 4752 | 10 | 35 | 51 |
Total number of gains: 33; Total number of losses: 170; Total Number of normals: 285.
Somatic mutations of NEK3:
Generating mutation plots.
Highly correlated genes for NEK3:
Showing top 20/780 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NEK3 | SEL1L3 | 0.837087 | 3 | 0 | 3 |
| NEK3 | TP53I13 | 0.822 | 3 | 0 | 3 |
| NEK3 | USP22 | 0.794868 | 3 | 0 | 3 |
| NEK3 | PRPS1 | 0.792631 | 3 | 0 | 3 |
| NEK3 | BORA | 0.791645 | 3 | 0 | 3 |
| NEK3 | LARP7 | 0.788893 | 3 | 0 | 3 |
| NEK3 | ELF4 | 0.780051 | 3 | 0 | 3 |
| NEK3 | SLC38A6 | 0.779557 | 3 | 0 | 3 |
| NEK3 | NOL9 | 0.776163 | 3 | 0 | 3 |
| NEK3 | LPCAT1 | 0.768283 | 3 | 0 | 3 |
| NEK3 | NOL7 | 0.766427 | 3 | 0 | 3 |
| NEK3 | DDX56 | 0.766063 | 3 | 0 | 3 |
| NEK3 | TAF2 | 0.7639 | 3 | 0 | 3 |
| NEK3 | ABCB7 | 0.760027 | 3 | 0 | 3 |
| NEK3 | FOXK2 | 0.756147 | 3 | 0 | 3 |
| NEK3 | DNAH14 | 0.755211 | 3 | 0 | 3 |
| NEK3 | WIZ | 0.747749 | 3 | 0 | 3 |
| NEK3 | BRAT1 | 0.746788 | 3 | 0 | 3 |
| NEK3 | IRF2BPL | 0.74349 | 3 | 0 | 3 |
| NEK3 | IWS1 | 0.743362 | 3 | 0 | 3 |
For details and further investigation, click here
