| Full name: methyltransferase like 14 | Alias Symbol: KIAA1627 | ||
| Type: protein-coding gene | Cytoband: 4q26 | ||
| Entrez ID: 57721 | HGNC ID: HGNC:29330 | Ensembl Gene: ENSG00000145388 | OMIM ID: 616504 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of METTL14:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | METTL14 | 57721 | 227601_at | 0.1448 | 0.7682 | |
| GSE26886 | METTL14 | 57721 | 235552_at | -0.9509 | 0.0004 | |
| GSE45670 | METTL14 | 57721 | 227601_at | -0.1337 | 0.3368 | |
| GSE53622 | METTL14 | 57721 | 105742 | -0.1588 | 0.0061 | |
| GSE53624 | METTL14 | 57721 | 105742 | -0.2301 | 0.0005 | |
| GSE63941 | METTL14 | 57721 | 227601_at | -0.2982 | 0.4395 | |
| GSE77861 | METTL14 | 57721 | 235552_at | -0.1403 | 0.5288 | |
| GSE97050 | METTL14 | 57721 | A_23_P110243 | 0.0373 | 0.8882 | |
| SRP007169 | METTL14 | 57721 | RNAseq | -0.3243 | 0.4091 | |
| SRP008496 | METTL14 | 57721 | RNAseq | -0.2030 | 0.4092 | |
| SRP064894 | METTL14 | 57721 | RNAseq | -0.2298 | 0.0661 | |
| SRP133303 | METTL14 | 57721 | RNAseq | 0.2022 | 0.2507 | |
| SRP159526 | METTL14 | 57721 | RNAseq | -0.4446 | 0.0442 | |
| SRP193095 | METTL14 | 57721 | RNAseq | -0.3215 | 0.0001 | |
| SRP219564 | METTL14 | 57721 | RNAseq | -0.3243 | 0.0807 | |
| TCGA | METTL14 | 57721 | RNAseq | -0.1337 | 0.0261 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by METTL14 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of METTL14:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | METTL14 | 57721 | 0 | 13 | 17 | |
| GSE20123 | METTL14 | 57721 | 1 | 13 | 16 | |
| GSE43470 | METTL14 | 57721 | 0 | 13 | 30 | |
| GSE46452 | METTL14 | 57721 | 1 | 36 | 22 | |
| GSE47630 | METTL14 | 57721 | 0 | 22 | 18 | |
| GSE54993 | METTL14 | 57721 | 9 | 0 | 61 | |
| GSE54994 | METTL14 | 57721 | 1 | 10 | 42 | |
| GSE60625 | METTL14 | 57721 | 0 | 1 | 10 | |
| GSE74703 | METTL14 | 57721 | 0 | 11 | 25 | |
| GSE74704 | METTL14 | 57721 | 0 | 7 | 13 | |
| TCGA | METTL14 | 57721 | 9 | 34 | 53 |
Total number of gains: 21; Total number of losses: 160; Total Number of normals: 307.
Somatic mutations of METTL14:
Generating mutation plots.
Highly correlated genes for METTL14:
Showing top 20/386 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| METTL14 | WWP1 | 0.863721 | 3 | 0 | 3 |
| METTL14 | ZNF814 | 0.801507 | 3 | 0 | 3 |
| METTL14 | CDC5L | 0.790275 | 3 | 0 | 3 |
| METTL14 | TTC14 | 0.7879 | 3 | 0 | 3 |
| METTL14 | RBM8A | 0.786351 | 3 | 0 | 3 |
| METTL14 | EIF3C | 0.772054 | 3 | 0 | 3 |
| METTL14 | METTL5 | 0.764022 | 3 | 0 | 3 |
| METTL14 | ZNF397 | 0.763166 | 3 | 0 | 3 |
| METTL14 | MAN2B2 | 0.756188 | 3 | 0 | 3 |
| METTL14 | COIL | 0.755962 | 3 | 0 | 3 |
| METTL14 | DNAJC3 | 0.755299 | 3 | 0 | 3 |
| METTL14 | UHRF2 | 0.751756 | 3 | 0 | 3 |
| METTL14 | KLHL18 | 0.74682 | 3 | 0 | 3 |
| METTL14 | TBRG1 | 0.744583 | 3 | 0 | 3 |
| METTL14 | IFIH1 | 0.742472 | 3 | 0 | 3 |
| METTL14 | CRNKL1 | 0.73633 | 3 | 0 | 3 |
| METTL14 | PPM1B | 0.73506 | 3 | 0 | 3 |
| METTL14 | AKAP17A | 0.735012 | 4 | 0 | 3 |
| METTL14 | ZNF564 | 0.734698 | 3 | 0 | 3 |
| METTL14 | TRAPPC10 | 0.734288 | 3 | 0 | 3 |
For details and further investigation, click here
