PRKG1

 

Full name: protein kinase cGMP-dependent 1 Alias Symbol: PGK|PKG|PKG1
Type: protein-coding gene Cytoband: 10q11.23-q21.1
Entrez ID: 5592 HGNC ID: HGNC:9414 Ensembl Gene: ENSG00000185532 OMIM ID: 176894
Drug and gene relationship at DGIdb

 

PRKG1 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04730Long-term depression
hsa04740Olfactory transduction
hsa04923Regulation of lipolysis in adipocytes
hsa04970Salivary secretion

 

Expression of PRKG1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKG1 5592 228396_at -0.4565 0.6145
GSE20347 PRKG1 5592 211380_s_at 0.0065 0.9497
GSE23400 PRKG1 5592 211380_s_at -0.1931 0.0000
GSE26886 PRKG1 5592 228396_at 1.6016 0.0002
GSE29001 PRKG1 5592 211380_s_at -0.2243 0.1512
GSE38129 PRKG1 5592 211380_s_at -0.2186 0.0559
GSE45670 PRKG1 5592 228396_at -1.3273 0.0003
GSE53622 PRKG1 5592 8005 -0.2155 0.1846
GSE53624 PRKG1 5592 3770 0.1187 0.4435
GSE63941 PRKG1 5592 228396_at -4.7238 0.0000
GSE77861 PRKG1 5592 228396_at 0.3254 0.1287
GSE97050 PRKG1 5592 A_24_P250765 -0.6657 0.1292
SRP007169 PRKG1 5592 RNAseq 2.5486 0.0000
SRP008496 PRKG1 5592 RNAseq 3.0147 0.0000
SRP064894 PRKG1 5592 RNAseq 0.3109 0.3170
SRP133303 PRKG1 5592 RNAseq 0.3127 0.3414
SRP159526 PRKG1 5592 RNAseq -0.2908 0.5600
SRP193095 PRKG1 5592 RNAseq 1.3148 0.0002
SRP219564 PRKG1 5592 RNAseq -0.3688 0.6573
TCGA PRKG1 5592 RNAseq -0.4899 0.0285

Upregulated datasets: 4; Downregulated datasets: 2.  

 

Survival by PRKG1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKG1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKG1 5592 3 5 22
GSE20123 PRKG1 5592 4 5 21
GSE43470 PRKG1 5592 2 5 36
GSE46452 PRKG1 5592 0 13 46
GSE47630 PRKG1 5592 4 12 24
GSE54993 PRKG1 5592 9 0 61
GSE54994 PRKG1 5592 2 11 40
GSE60625 PRKG1 5592 0 0 11
GSE74703 PRKG1 5592 2 3 31
GSE74704 PRKG1 5592 1 4 15
TCGA PRKG1 5592 15 24 57

Total number of gains: 42; Total number of losses: 82; Total Number of normals: 364.  

 

Somatic mutations of PRKG1:

 

Generating mutation plots.

 

Highly correlated genes for PRKG1:

 

Showing top 20/1088 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKG1ITGA10.84432707
PRKG1MRGPRF0.839621707
PRKG1MSRB30.820048606
PRKG1MGARP0.815952303
PRKG1MCAM0.800064707
PRKG1LRCH20.793119606
PRKG1SGIP10.787467808
PRKG1HMCN10.786615808
PRKG1INMT0.774928606
PRKG1ZEB10.771798303
PRKG1CLMP0.770857706
PRKG1DACT30.767514606
PRKG1C11orf960.766291505
PRKG1ZCCHC240.76473908
PRKG1ADAMTS50.762213909
PRKG1ANTXR20.759452707
PRKG1DOCK110.756942606
PRKG1TNFSF120.754569303
PRKG1TBX5-AS10.75428505
PRKG1JAM30.753163908

For details and further investigation, click here