| Full name: ADAM metallopeptidase with thrombospondin type 1 motif 5 | Alias Symbol: ADMP-2|ADAMTS11 | ||
| Type: protein-coding gene | Cytoband: 21q21.3 | ||
| Entrez ID: 11096 | HGNC ID: HGNC:221 | Ensembl Gene: ENSG00000154736 | OMIM ID: 605007 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAMTS5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAMTS5 | 11096 | 219935_at | -2.1726 | 0.0717 | |
| GSE20347 | ADAMTS5 | 11096 | 219935_at | 0.0940 | 0.7771 | |
| GSE23400 | ADAMTS5 | 11096 | 219935_at | -0.4008 | 0.0031 | |
| GSE26886 | ADAMTS5 | 11096 | 229357_at | 1.0639 | 0.0930 | |
| GSE29001 | ADAMTS5 | 11096 | 219935_at | -0.3096 | 0.4673 | |
| GSE38129 | ADAMTS5 | 11096 | 219935_at | -0.7225 | 0.0687 | |
| GSE45670 | ADAMTS5 | 11096 | 219935_at | -2.2085 | 0.0000 | |
| GSE53622 | ADAMTS5 | 11096 | 13345 | -0.8560 | 0.0000 | |
| GSE53624 | ADAMTS5 | 11096 | 13345 | -0.3603 | 0.0395 | |
| GSE63941 | ADAMTS5 | 11096 | 229357_at | -8.2831 | 0.0000 | |
| GSE77861 | ADAMTS5 | 11096 | 229357_at | 0.1248 | 0.2654 | |
| GSE97050 | ADAMTS5 | 11096 | A_33_P3372426 | -0.6430 | 0.1297 | |
| SRP007169 | ADAMTS5 | 11096 | RNAseq | 3.2272 | 0.0000 | |
| SRP008496 | ADAMTS5 | 11096 | RNAseq | 3.8079 | 0.0000 | |
| SRP064894 | ADAMTS5 | 11096 | RNAseq | 0.0936 | 0.8151 | |
| SRP133303 | ADAMTS5 | 11096 | RNAseq | 0.0431 | 0.9178 | |
| SRP159526 | ADAMTS5 | 11096 | RNAseq | 0.3208 | 0.5776 | |
| SRP193095 | ADAMTS5 | 11096 | RNAseq | 1.9221 | 0.0000 | |
| SRP219564 | ADAMTS5 | 11096 | RNAseq | -0.2078 | 0.7875 | |
| TCGA | ADAMTS5 | 11096 | RNAseq | -0.4972 | 0.0069 |
Upregulated datasets: 3; Downregulated datasets: 2.
Survival by ADAMTS5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAMTS5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAMTS5 | 11096 | 2 | 11 | 17 | |
| GSE20123 | ADAMTS5 | 11096 | 2 | 11 | 17 | |
| GSE43470 | ADAMTS5 | 11096 | 1 | 8 | 34 | |
| GSE46452 | ADAMTS5 | 11096 | 1 | 21 | 37 | |
| GSE47630 | ADAMTS5 | 11096 | 6 | 17 | 17 | |
| GSE54993 | ADAMTS5 | 11096 | 9 | 2 | 59 | |
| GSE54994 | ADAMTS5 | 11096 | 2 | 8 | 43 | |
| GSE60625 | ADAMTS5 | 11096 | 0 | 0 | 11 | |
| GSE74703 | ADAMTS5 | 11096 | 1 | 6 | 29 | |
| GSE74704 | ADAMTS5 | 11096 | 2 | 7 | 11 | |
| TCGA | ADAMTS5 | 11096 | 8 | 37 | 51 |
Total number of gains: 34; Total number of losses: 128; Total Number of normals: 326.
Somatic mutations of ADAMTS5:
Generating mutation plots.
Highly correlated genes for ADAMTS5:
Showing top 20/1274 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAMTS5 | MAGI2-AS3 | 0.822469 | 6 | 0 | 6 |
| ADAMTS5 | RBM24 | 0.793007 | 5 | 0 | 5 |
| ADAMTS5 | CNRIP1 | 0.788549 | 9 | 0 | 8 |
| ADAMTS5 | ZNF583 | 0.787701 | 3 | 0 | 3 |
| ADAMTS5 | CYP2U1 | 0.783303 | 6 | 0 | 6 |
| ADAMTS5 | LRRN4CL | 0.782365 | 8 | 0 | 7 |
| ADAMTS5 | PGR | 0.781881 | 5 | 0 | 5 |
| ADAMTS5 | KBTBD11 | 0.774223 | 6 | 0 | 6 |
| ADAMTS5 | RSPO3 | 0.771534 | 7 | 0 | 6 |
| ADAMTS5 | AGTR1 | 0.770452 | 10 | 0 | 9 |
| ADAMTS5 | ADARB1 | 0.769899 | 7 | 0 | 7 |
| ADAMTS5 | DDR2 | 0.769343 | 12 | 0 | 11 |
| ADAMTS5 | LRCH2 | 0.768474 | 7 | 0 | 6 |
| ADAMTS5 | KCNT2 | 0.7649 | 7 | 0 | 7 |
| ADAMTS5 | RASSF3 | 0.762464 | 4 | 0 | 4 |
| ADAMTS5 | PRKG1 | 0.762213 | 9 | 0 | 9 |
| ADAMTS5 | GNG2 | 0.761204 | 5 | 0 | 5 |
| ADAMTS5 | JAM3 | 0.75964 | 12 | 0 | 12 |
| ADAMTS5 | GPRASP1 | 0.759296 | 8 | 0 | 8 |
| ADAMTS5 | DCHS1 | 0.758217 | 9 | 0 | 8 |
For details and further investigation, click here
