| Full name: pre-mRNA processing factor 6 | Alias Symbol: TOM|bB152O15.1|ANT-1|U5-102K|Prp6|hPrp6|SNRNP102|RP60 | ||
| Type: protein-coding gene | Cytoband: 20q13.33 | ||
| Entrez ID: 24148 | HGNC ID: HGNC:15860 | Ensembl Gene: ENSG00000101161 | OMIM ID: 613979 |
| Drug and gene relationship at DGIdb | |||
Expression of PRPF6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRPF6 | 24148 | 208880_s_at | 0.3194 | 0.3529 | |
| GSE20347 | PRPF6 | 24148 | 208880_s_at | -0.0775 | 0.5799 | |
| GSE23400 | PRPF6 | 24148 | 208880_s_at | 0.0544 | 0.3774 | |
| GSE26886 | PRPF6 | 24148 | 208880_s_at | 0.0716 | 0.7744 | |
| GSE29001 | PRPF6 | 24148 | 208880_s_at | 0.2067 | 0.5860 | |
| GSE38129 | PRPF6 | 24148 | 208880_s_at | -0.0190 | 0.8936 | |
| GSE45670 | PRPF6 | 24148 | 208880_s_at | 0.3121 | 0.0103 | |
| GSE53622 | PRPF6 | 24148 | 6263 | 0.0043 | 0.9458 | |
| GSE53624 | PRPF6 | 24148 | 6263 | 0.1356 | 0.0122 | |
| GSE63941 | PRPF6 | 24148 | 208880_s_at | 0.7750 | 0.0691 | |
| GSE77861 | PRPF6 | 24148 | 208880_s_at | 0.0952 | 0.6615 | |
| GSE97050 | PRPF6 | 24148 | A_23_P154539 | 0.2148 | 0.3447 | |
| SRP007169 | PRPF6 | 24148 | RNAseq | 0.1882 | 0.6610 | |
| SRP008496 | PRPF6 | 24148 | RNAseq | 0.1542 | 0.5845 | |
| SRP064894 | PRPF6 | 24148 | RNAseq | 0.4481 | 0.0333 | |
| SRP133303 | PRPF6 | 24148 | RNAseq | 0.0644 | 0.5954 | |
| SRP159526 | PRPF6 | 24148 | RNAseq | 0.0032 | 0.9862 | |
| SRP193095 | PRPF6 | 24148 | RNAseq | 0.1423 | 0.0910 | |
| SRP219564 | PRPF6 | 24148 | RNAseq | 0.2992 | 0.2552 | |
| TCGA | PRPF6 | 24148 | RNAseq | 0.0208 | 0.6368 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PRPF6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRPF6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRPF6 | 24148 | 13 | 2 | 15 | |
| GSE20123 | PRPF6 | 24148 | 13 | 2 | 15 | |
| GSE43470 | PRPF6 | 24148 | 11 | 1 | 31 | |
| GSE46452 | PRPF6 | 24148 | 35 | 0 | 24 | |
| GSE47630 | PRPF6 | 24148 | 25 | 1 | 14 | |
| GSE54993 | PRPF6 | 24148 | 0 | 17 | 53 | |
| GSE54994 | PRPF6 | 24148 | 29 | 0 | 24 | |
| GSE60625 | PRPF6 | 24148 | 0 | 0 | 11 | |
| GSE74703 | PRPF6 | 24148 | 10 | 0 | 26 | |
| GSE74704 | PRPF6 | 24148 | 10 | 0 | 10 | |
| TCGA | PRPF6 | 24148 | 44 | 4 | 48 |
Total number of gains: 190; Total number of losses: 27; Total Number of normals: 271.
Somatic mutations of PRPF6:
Generating mutation plots.
Highly correlated genes for PRPF6:
Showing top 20/105 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRPF6 | FOXK1 | 0.718982 | 3 | 0 | 3 |
| PRPF6 | SLC34A1 | 0.66942 | 3 | 0 | 3 |
| PRPF6 | TCHH | 0.662763 | 3 | 0 | 3 |
| PRPF6 | IL17RE | 0.662679 | 3 | 0 | 3 |
| PRPF6 | CYTH1 | 0.657512 | 4 | 0 | 4 |
| PRPF6 | GNL1 | 0.654182 | 3 | 0 | 3 |
| PRPF6 | ZSWIM3 | 0.653115 | 4 | 0 | 3 |
| PRPF6 | HES2 | 0.652691 | 3 | 0 | 3 |
| PRPF6 | TAF4 | 0.652208 | 6 | 0 | 5 |
| PRPF6 | PUS1 | 0.649068 | 4 | 0 | 3 |
| PRPF6 | CDC6 | 0.647301 | 3 | 0 | 3 |
| PRPF6 | FBXO22 | 0.639574 | 3 | 0 | 3 |
| PRPF6 | ENOX2 | 0.635996 | 3 | 0 | 3 |
| PRPF6 | ADCK5 | 0.633995 | 4 | 0 | 3 |
| PRPF6 | RALY | 0.626848 | 11 | 0 | 10 |
| PRPF6 | HIRIP3 | 0.624982 | 5 | 0 | 4 |
| PRPF6 | TIMM22 | 0.62488 | 4 | 0 | 3 |
| PRPF6 | RNF123 | 0.624584 | 3 | 0 | 3 |
| PRPF6 | PINX1 | 0.618727 | 3 | 0 | 3 |
| PRPF6 | TFAP2C | 0.61446 | 6 | 0 | 5 |
For details and further investigation, click here
