| Full name: TATA-box binding protein associated factor 4 | Alias Symbol: TAFII130|TAFII135 | ||
| Type: protein-coding gene | Cytoband: 20q13.33 | ||
| Entrez ID: 6874 | HGNC ID: HGNC:11537 | Ensembl Gene: ENSG00000130699 | OMIM ID: 601796 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TAF4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TAF4 | 6874 | 213090_s_at | 1.0127 | 0.0258 | |
| GSE20347 | TAF4 | 6874 | 213090_s_at | 0.8591 | 0.0000 | |
| GSE23400 | TAF4 | 6874 | 213090_s_at | 0.4549 | 0.0000 | |
| GSE26886 | TAF4 | 6874 | 213090_s_at | 0.4848 | 0.0452 | |
| GSE29001 | TAF4 | 6874 | 213090_s_at | 0.7303 | 0.0010 | |
| GSE38129 | TAF4 | 6874 | 213090_s_at | 0.6387 | 0.0000 | |
| GSE45670 | TAF4 | 6874 | 213090_s_at | 0.3792 | 0.0260 | |
| GSE53622 | TAF4 | 6874 | 90543 | 0.2623 | 0.0000 | |
| GSE53624 | TAF4 | 6874 | 90543 | 0.2535 | 0.0001 | |
| GSE63941 | TAF4 | 6874 | 213090_s_at | 1.2603 | 0.0061 | |
| GSE77861 | TAF4 | 6874 | 213090_s_at | 0.6814 | 0.0094 | |
| GSE97050 | TAF4 | 6874 | A_23_P80062 | 0.2220 | 0.4824 | |
| SRP007169 | TAF4 | 6874 | RNAseq | 1.2702 | 0.0155 | |
| SRP008496 | TAF4 | 6874 | RNAseq | 1.0438 | 0.0100 | |
| SRP064894 | TAF4 | 6874 | RNAseq | 0.1858 | 0.4529 | |
| SRP133303 | TAF4 | 6874 | RNAseq | 0.4343 | 0.0084 | |
| SRP159526 | TAF4 | 6874 | RNAseq | 0.6306 | 0.0301 | |
| SRP193095 | TAF4 | 6874 | RNAseq | 0.3279 | 0.0089 | |
| SRP219564 | TAF4 | 6874 | RNAseq | 0.5452 | 0.1421 | |
| TCGA | TAF4 | 6874 | RNAseq | 0.1014 | 0.0496 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by TAF4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TAF4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TAF4 | 6874 | 13 | 2 | 15 | |
| GSE20123 | TAF4 | 6874 | 14 | 2 | 14 | |
| GSE43470 | TAF4 | 6874 | 11 | 1 | 31 | |
| GSE46452 | TAF4 | 6874 | 35 | 0 | 24 | |
| GSE47630 | TAF4 | 6874 | 25 | 1 | 14 | |
| GSE54993 | TAF4 | 6874 | 0 | 17 | 53 | |
| GSE54994 | TAF4 | 6874 | 29 | 0 | 24 | |
| GSE60625 | TAF4 | 6874 | 0 | 0 | 11 | |
| GSE74703 | TAF4 | 6874 | 10 | 0 | 26 | |
| GSE74704 | TAF4 | 6874 | 11 | 0 | 9 | |
| TCGA | TAF4 | 6874 | 43 | 4 | 49 |
Total number of gains: 191; Total number of losses: 27; Total Number of normals: 270.
Somatic mutations of TAF4:
Generating mutation plots.
Highly correlated genes for TAF4:
Showing top 20/474 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TAF4 | SOX30 | 0.738128 | 3 | 0 | 3 |
| TAF4 | TTI1 | 0.726861 | 10 | 0 | 9 |
| TAF4 | MRGBP | 0.707837 | 10 | 0 | 10 |
| TAF4 | MTERF3 | 0.701671 | 8 | 0 | 7 |
| TAF4 | MAK | 0.682583 | 4 | 0 | 4 |
| TAF4 | SDCCAG8 | 0.676583 | 4 | 0 | 4 |
| TAF4 | CSTF1 | 0.671144 | 11 | 0 | 10 |
| TAF4 | RBM28 | 0.670701 | 9 | 0 | 8 |
| TAF4 | NADK2 | 0.663478 | 3 | 0 | 3 |
| TAF4 | MYBL2 | 0.66301 | 9 | 0 | 7 |
| TAF4 | MCM2 | 0.662113 | 10 | 0 | 9 |
| TAF4 | YBX1 | 0.657272 | 5 | 0 | 4 |
| TAF4 | NELFCD | 0.655331 | 11 | 0 | 11 |
| TAF4 | ODC1 | 0.653322 | 6 | 0 | 5 |
| TAF4 | KIF14 | 0.652586 | 8 | 0 | 7 |
| TAF4 | PRPF6 | 0.652208 | 6 | 0 | 5 |
| TAF4 | ZNF77 | 0.652036 | 4 | 0 | 3 |
| TAF4 | ZNF678 | 0.650274 | 4 | 0 | 3 |
| TAF4 | MIIP | 0.648332 | 4 | 0 | 3 |
| TAF4 | ENTPD6 | 0.64672 | 8 | 0 | 7 |
For details and further investigation, click here
