| Full name: PIN2 (TERF1) interacting telomerase inhibitor 1 | Alias Symbol: PinX1|LPTL|LPTS|FLJ20565|MGC8850|Gno1|Pxr1 | ||
| Type: protein-coding gene | Cytoband: 8p23.1 | ||
| Entrez ID: 54984 | HGNC ID: HGNC:30046 | Ensembl Gene: ENSG00000254093 | OMIM ID: 606505 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PINX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PINX1 | 54984 | 223907_s_at | 0.5730 | 0.1771 | |
| GSE26886 | PINX1 | 54984 | 223907_s_at | 0.5982 | 0.0045 | |
| GSE45670 | PINX1 | 54984 | 223907_s_at | 0.3012 | 0.0390 | |
| GSE53622 | PINX1 | 54984 | 45964 | 0.2507 | 0.0000 | |
| GSE53624 | PINX1 | 54984 | 45964 | 0.2710 | 0.0000 | |
| GSE63941 | PINX1 | 54984 | 223907_s_at | 0.2972 | 0.6267 | |
| GSE77861 | PINX1 | 54984 | 223907_s_at | 0.2075 | 0.3023 | |
| GSE97050 | PINX1 | 54984 | A_23_P82823 | 0.1467 | 0.4536 | |
| SRP007169 | PINX1 | 54984 | RNAseq | 1.4187 | 0.0479 | |
| SRP064894 | PINX1 | 54984 | RNAseq | 0.2567 | 0.2916 | |
| SRP133303 | PINX1 | 54984 | RNAseq | 0.1160 | 0.5455 | |
| SRP159526 | PINX1 | 54984 | RNAseq | 0.4100 | 0.3823 | |
| SRP193095 | PINX1 | 54984 | RNAseq | 0.0347 | 0.8423 | |
| SRP219564 | PINX1 | 54984 | RNAseq | 0.0255 | 0.9103 | |
| TCGA | PINX1 | 54984 | RNAseq | 0.1710 | 0.0668 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PINX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PINX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PINX1 | 54984 | 4 | 11 | 15 | |
| GSE20123 | PINX1 | 54984 | 4 | 11 | 15 | |
| GSE43470 | PINX1 | 54984 | 4 | 9 | 30 | |
| GSE46452 | PINX1 | 54984 | 12 | 14 | 33 | |
| GSE47630 | PINX1 | 54984 | 10 | 7 | 23 | |
| GSE54993 | PINX1 | 54984 | 3 | 14 | 53 | |
| GSE54994 | PINX1 | 54984 | 9 | 19 | 25 | |
| GSE60625 | PINX1 | 54984 | 3 | 0 | 8 | |
| GSE74703 | PINX1 | 54984 | 4 | 7 | 25 | |
| GSE74704 | PINX1 | 54984 | 3 | 7 | 10 | |
| TCGA | PINX1 | 54984 | 14 | 39 | 43 |
Total number of gains: 70; Total number of losses: 138; Total Number of normals: 280.
Somatic mutations of PINX1:
Generating mutation plots.
Highly correlated genes for PINX1:
Showing top 20/184 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PINX1 | HGD | 0.775501 | 3 | 0 | 3 |
| PINX1 | DHRS2 | 0.770791 | 3 | 0 | 3 |
| PINX1 | RIN1 | 0.728128 | 3 | 0 | 3 |
| PINX1 | GRIN1 | 0.718648 | 3 | 0 | 3 |
| PINX1 | C19orf53 | 0.718163 | 3 | 0 | 3 |
| PINX1 | TTPAL | 0.714798 | 4 | 0 | 4 |
| PINX1 | GHSR | 0.696842 | 3 | 0 | 3 |
| PINX1 | RABGEF1 | 0.694811 | 3 | 0 | 3 |
| PINX1 | JSRP1 | 0.693714 | 3 | 0 | 3 |
| PINX1 | CLSTN3 | 0.692492 | 3 | 0 | 3 |
| PINX1 | C19orf81 | 0.686542 | 3 | 0 | 3 |
| PINX1 | SPATA2L | 0.683759 | 5 | 0 | 4 |
| PINX1 | SHROOM1 | 0.683005 | 3 | 0 | 3 |
| PINX1 | VAV2 | 0.679862 | 4 | 0 | 3 |
| PINX1 | CDRT15 | 0.674968 | 3 | 0 | 3 |
| PINX1 | HOMER1 | 0.665467 | 5 | 0 | 4 |
| PINX1 | FBXO45 | 0.663225 | 3 | 0 | 3 |
| PINX1 | TMCC2 | 0.661493 | 4 | 0 | 4 |
| PINX1 | LRRC8E | 0.660242 | 4 | 0 | 3 |
| PINX1 | SBNO2 | 0.657225 | 3 | 0 | 3 |
For details and further investigation, click here
