| Full name: cell division cycle 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 990 | HGNC ID: HGNC:1744 | Ensembl Gene: ENSG00000094804 | OMIM ID: 602627 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
CDC6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle |
Expression of CDC6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDC6 | 990 | 203967_at | 1.9426 | 0.0690 | |
| GSE20347 | CDC6 | 990 | 203967_at | 1.8554 | 0.0000 | |
| GSE23400 | CDC6 | 990 | 203967_at | 1.0210 | 0.0000 | |
| GSE26886 | CDC6 | 990 | 203968_s_at | 1.0376 | 0.0028 | |
| GSE29001 | CDC6 | 990 | 203967_at | 1.3571 | 0.0008 | |
| GSE38129 | CDC6 | 990 | 203968_s_at | 1.8896 | 0.0000 | |
| GSE45670 | CDC6 | 990 | 203968_s_at | 1.8602 | 0.0000 | |
| GSE53622 | CDC6 | 990 | 15584 | 0.2693 | 0.0002 | |
| GSE53624 | CDC6 | 990 | 15584 | 0.3061 | 0.0023 | |
| GSE63941 | CDC6 | 990 | 203968_s_at | 3.1388 | 0.0003 | |
| GSE77861 | CDC6 | 990 | 203968_s_at | 1.0508 | 0.0025 | |
| GSE97050 | CDC6 | 990 | A_33_P3218450 | 0.0621 | 0.8292 | |
| SRP007169 | CDC6 | 990 | RNAseq | 3.6409 | 0.0000 | |
| SRP008496 | CDC6 | 990 | RNAseq | 2.7430 | 0.0000 | |
| SRP064894 | CDC6 | 990 | RNAseq | 1.8170 | 0.0000 | |
| SRP133303 | CDC6 | 990 | RNAseq | 1.9705 | 0.0000 | |
| SRP159526 | CDC6 | 990 | RNAseq | 1.9564 | 0.0000 | |
| SRP193095 | CDC6 | 990 | RNAseq | 1.3525 | 0.0000 | |
| SRP219564 | CDC6 | 990 | RNAseq | 2.3543 | 0.0007 | |
| TCGA | CDC6 | 990 | RNAseq | 1.2194 | 0.0000 |
Upregulated datasets: 16; Downregulated datasets: 0.
Survival by CDC6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDC6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDC6 | 990 | 8 | 1 | 21 | |
| GSE20123 | CDC6 | 990 | 8 | 1 | 21 | |
| GSE43470 | CDC6 | 990 | 1 | 2 | 40 | |
| GSE46452 | CDC6 | 990 | 34 | 0 | 25 | |
| GSE47630 | CDC6 | 990 | 8 | 1 | 31 | |
| GSE54993 | CDC6 | 990 | 3 | 4 | 63 | |
| GSE54994 | CDC6 | 990 | 8 | 5 | 40 | |
| GSE60625 | CDC6 | 990 | 4 | 0 | 7 | |
| GSE74703 | CDC6 | 990 | 1 | 1 | 34 | |
| GSE74704 | CDC6 | 990 | 5 | 1 | 14 | |
| TCGA | CDC6 | 990 | 22 | 8 | 66 |
Total number of gains: 102; Total number of losses: 24; Total Number of normals: 362.
Somatic mutations of CDC6:
Generating mutation plots.
Highly correlated genes for CDC6:
Showing top 20/580 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDC6 | CDCA5 | 0.883996 | 6 | 0 | 6 |
| CDC6 | RAD51 | 0.850357 | 10 | 0 | 10 |
| CDC6 | KIF4A | 0.849759 | 10 | 0 | 10 |
| CDC6 | FEN1 | 0.843147 | 10 | 0 | 10 |
| CDC6 | RAD51AP1 | 0.832457 | 9 | 0 | 9 |
| CDC6 | TRIP13 | 0.829184 | 9 | 0 | 9 |
| CDC6 | AURKB | 0.828514 | 9 | 0 | 9 |
| CDC6 | UHRF1 | 0.826255 | 5 | 0 | 5 |
| CDC6 | GINS2 | 0.826219 | 10 | 0 | 10 |
| CDC6 | CDC20 | 0.821753 | 10 | 0 | 10 |
| CDC6 | MTFR2 | 0.818842 | 5 | 0 | 5 |
| CDC6 | CKS1B | 0.817717 | 9 | 0 | 9 |
| CDC6 | RFC4 | 0.814688 | 9 | 0 | 9 |
| CDC6 | CDC45 | 0.814603 | 9 | 0 | 9 |
| CDC6 | PNPT1 | 0.813868 | 3 | 0 | 3 |
| CDC6 | BUB1B | 0.812241 | 10 | 0 | 10 |
| CDC6 | CDK1 | 0.805976 | 9 | 0 | 9 |
| CDC6 | EXO1 | 0.804018 | 10 | 0 | 10 |
| CDC6 | KIF2C | 0.801261 | 9 | 0 | 9 |
| CDC6 | STIL | 0.798277 | 9 | 0 | 9 |
For details and further investigation, click here
