CKS1B

 

Full name: CDC28 protein kinase regulatory subunit 1B Alias Symbol: ckshs1|CKS1
Type: protein-coding gene Cytoband: 1q21.3
Entrez ID: 1163 HGNC ID: HGNC:19083 Ensembl Gene: ENSG00000173207 OMIM ID: 116900
Drug and gene relationship at DGIdb

 

CKS1B involved pathways:

KEGG pathway Description View
hsa05200Pathways in cancer
hsa05222Small cell lung cancer

 

Expression of CKS1B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CKS1B 1163 201897_s_at 1.3883 0.0054
GSE20347 CKS1B 1163 201897_s_at 1.8311 0.0000
GSE23400 CKS1B 1163 201897_s_at 1.6873 0.0000
GSE26886 CKS1B 1163 201897_s_at 0.9773 0.0002
GSE29001 CKS1B 1163 201897_s_at 1.7084 0.0001
GSE38129 CKS1B 1163 201897_s_at 1.9464 0.0000
GSE45670 CKS1B 1163 201897_s_at 1.0479 0.0000
GSE53622 CKS1B 1163 144499 1.3293 0.0000
GSE53624 CKS1B 1163 144499 1.7285 0.0000
GSE63941 CKS1B 1163 201897_s_at 2.8252 0.0000
GSE77861 CKS1B 1163 201897_s_at 1.4138 0.0023
GSE97050 CKS1B 1163 A_23_P45917 0.8678 0.1131
SRP007169 CKS1B 1163 RNAseq 1.3636 0.0009
SRP008496 CKS1B 1163 RNAseq 1.2509 0.0001
SRP064894 CKS1B 1163 RNAseq 1.5391 0.0000
SRP133303 CKS1B 1163 RNAseq 1.4404 0.0000
SRP159526 CKS1B 1163 RNAseq 1.7234 0.0000
SRP193095 CKS1B 1163 RNAseq 1.0743 0.0000
SRP219564 CKS1B 1163 RNAseq 1.5946 0.0021
TCGA CKS1B 1163 RNAseq 0.7486 0.0000

Upregulated datasets: 17; Downregulated datasets: 0.  

 

Survival by CKS1B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CKS1B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CKS1B 1163 14 0 16
GSE20123 CKS1B 1163 13 0 17
GSE43470 CKS1B 1163 6 2 35
GSE46452 CKS1B 1163 2 1 56
GSE47630 CKS1B 1163 14 0 26
GSE54993 CKS1B 1163 0 4 66
GSE54994 CKS1B 1163 16 0 37
GSE60625 CKS1B 1163 0 0 11
GSE74703 CKS1B 1163 6 1 29
GSE74704 CKS1B 1163 6 0 14
TCGA CKS1B|ENSG00000173207.8 NA 38 2 56

Total number of gains: 115; Total number of losses: 10; Total Number of normals: 363.  

 

Somatic mutations of CKS1B:

 

Generating mutation plots.

 

Highly correlated genes for CKS1B:

 

Showing top 20/2008 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CKS1BUBE2T0.880622909
CKS1BCENPF0.86303912012
CKS1BTPX20.85094913013
CKS1BRFC40.85009913013
CKS1BKIF2C0.84763212012
CKS1BECT20.84694112012
CKS1BMYBL20.83675712012
CKS1BCDKN30.83309113013
CKS1BAURKB0.8300413012
CKS1BCBX30.82546411011
CKS1BDLGAP50.82512512012
CKS1BTOP2A0.82043312012
CKS1BRUVBL10.82010213013
CKS1BGINS10.81816612012
CKS1BCDK10.81804112011
CKS1BKIF4A0.81791212011
CKS1BCDC60.817717909
CKS1BSTIL0.8172312012
CKS1BBIRC50.81618911011
CKS1BKIF140.81586313012

For details and further investigation, click here