PSIP1

 

Full name: PC4 and SFRS1 interacting protein 1 Alias Symbol: p52|LEDGF|p75|DFS70
Type: protein-coding gene Cytoband: 9p22.3
Entrez ID: 11168 HGNC ID: HGNC:9527 Ensembl Gene: ENSG00000164985 OMIM ID: 603620
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 4/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of PSIP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PSIP1 11168 209337_at -0.7100 0.3538
GSE20347 PSIP1 11168 209337_at 0.1779 0.4893
GSE23400 PSIP1 11168 209337_at 0.0379 0.8209
GSE26886 PSIP1 11168 209337_at 0.2452 0.4055
GSE29001 PSIP1 11168 209337_at 0.7825 0.0832
GSE38129 PSIP1 11168 209337_at -0.2259 0.4702
GSE45670 PSIP1 11168 209337_at -0.9495 0.0095
GSE53622 PSIP1 11168 45020 -0.5010 0.0000
GSE53624 PSIP1 11168 45020 -0.2148 0.0116
GSE63941 PSIP1 11168 209337_at 0.2233 0.7878
GSE77861 PSIP1 11168 209337_at 0.4603 0.0468
GSE97050 PSIP1 11168 A_33_P3226610 -0.5574 0.2159
SRP007169 PSIP1 11168 RNAseq 1.4490 0.0075
SRP008496 PSIP1 11168 RNAseq 1.2579 0.0003
SRP064894 PSIP1 11168 RNAseq 0.2802 0.1295
SRP133303 PSIP1 11168 RNAseq -0.0116 0.9576
SRP159526 PSIP1 11168 RNAseq 0.1086 0.7006
SRP193095 PSIP1 11168 RNAseq -0.0873 0.4022
SRP219564 PSIP1 11168 RNAseq -0.0824 0.8353
TCGA PSIP1 11168 RNAseq -0.1591 0.0354

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by PSIP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PSIP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PSIP1 11168 2 16 12
GSE20123 PSIP1 11168 2 16 12
GSE43470 PSIP1 11168 5 11 27
GSE46452 PSIP1 11168 2 23 34
GSE47630 PSIP1 11168 4 26 10
GSE54993 PSIP1 11168 6 3 61
GSE54994 PSIP1 11168 10 16 27
GSE60625 PSIP1 11168 0 0 11
GSE74703 PSIP1 11168 5 8 23
GSE74704 PSIP1 11168 0 13 7
TCGA PSIP1 11168 13 50 33

Total number of gains: 49; Total number of losses: 182; Total Number of normals: 257.  

 

Somatic mutations of PSIP1:

 

Generating mutation plots.

 

Highly correlated genes for PSIP1:

 

Showing top 20/911 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PSIP1BHLHE220.798247303
PSIP1PLIN40.781932303
PSIP1SYNC0.756671404
PSIP1ERRFI10.753461303
PSIP1IGIP0.752549303
PSIP1ITGA70.745509606
PSIP1MRVI10.740367404
PSIP1MMGT10.738358303
PSIP1NOVA10.73283606
PSIP1KLHL230.730884504
PSIP1SLC29A10.726874404
PSIP1RGS7BP0.724112404
PSIP1MAPKAPK50.723456303
PSIP1MYOCD0.723412403
PSIP1ANO50.72317504
PSIP1ZNF33B0.722352303
PSIP1TMEM1870.72085303
PSIP1ARPP190.718378403
PSIP1PDE4DIP0.717091303
PSIP1PPP3CB0.713782605

For details and further investigation, click here