MAPKAPK5

 

Full name: MAPK activated protein kinase 5 Alias Symbol: PRAK
Type: protein-coding gene Cytoband: 12q24.12-q24.13
Entrez ID: 8550 HGNC ID: HGNC:6889 Ensembl Gene: ENSG00000089022 OMIM ID: 606723
Drug and gene relationship at DGIdb
Screen Evidence:

 

MAPKAPK5 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway

 

Expression of MAPKAPK5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MAPKAPK5 8550 212871_at 0.5231 0.1358
GSE20347 MAPKAPK5 8550 212871_at 0.7221 0.0000
GSE23400 MAPKAPK5 8550 212871_at 0.4865 0.0000
GSE26886 MAPKAPK5 8550 212871_at 1.0566 0.0002
GSE29001 MAPKAPK5 8550 212871_at 0.6866 0.0050
GSE38129 MAPKAPK5 8550 212871_at 0.7328 0.0000
GSE45670 MAPKAPK5 8550 212871_at 0.3033 0.0076
GSE53622 MAPKAPK5 8550 18048 0.2728 0.0000
GSE53624 MAPKAPK5 8550 18048 0.4380 0.0000
GSE63941 MAPKAPK5 8550 212871_at 0.2153 0.4549
GSE77861 MAPKAPK5 8550 212871_at 0.6024 0.0021
GSE97050 MAPKAPK5 8550 A_24_P124662 -0.1409 0.5688
SRP007169 MAPKAPK5 8550 RNAseq 0.4908 0.1659
SRP008496 MAPKAPK5 8550 RNAseq 0.3665 0.0816
SRP064894 MAPKAPK5 8550 RNAseq 0.3342 0.0062
SRP133303 MAPKAPK5 8550 RNAseq 0.2995 0.0926
SRP159526 MAPKAPK5 8550 RNAseq 0.4696 0.0026
SRP193095 MAPKAPK5 8550 RNAseq 0.2576 0.0043
SRP219564 MAPKAPK5 8550 RNAseq 0.2139 0.3537
TCGA MAPKAPK5 8550 RNAseq 0.0434 0.4217

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by MAPKAPK5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MAPKAPK5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MAPKAPK5 8550 5 3 22
GSE20123 MAPKAPK5 8550 5 3 22
GSE43470 MAPKAPK5 8550 2 1 40
GSE46452 MAPKAPK5 8550 9 1 49
GSE47630 MAPKAPK5 8550 9 3 28
GSE54993 MAPKAPK5 8550 0 5 65
GSE54994 MAPKAPK5 8550 4 2 47
GSE60625 MAPKAPK5 8550 0 0 11
GSE74703 MAPKAPK5 8550 2 0 34
GSE74704 MAPKAPK5 8550 2 2 16
TCGA MAPKAPK5 8550 22 11 63

Total number of gains: 60; Total number of losses: 31; Total Number of normals: 397.  

 

Somatic mutations of MAPKAPK5:

 

Generating mutation plots.

 

Highly correlated genes for MAPKAPK5:

 

Showing top 20/2048 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MAPKAPK5PKIG0.81373303
MAPKAPK5MGAT4B0.773228303
MAPKAPK5TMTC10.760552303
MAPKAPK5MRPL380.755385303
MAPKAPK5ZC3H12C0.755206303
MAPKAPK5PLEKHA30.754867303
MAPKAPK5C20orf1940.752687303
MAPKAPK5SESN30.752264303
MAPKAPK5LRRC580.751604505
MAPKAPK5CCT20.7444811011
MAPKAPK5PLEKHM30.738672303
MAPKAPK5TMC70.737098404
MAPKAPK5SLC39A30.7366303
MAPKAPK5NUP1070.73640212011
MAPKAPK5LEMD20.733439303
MAPKAPK5GPN30.73261813012
MAPKAPK5ATG4C0.725354303
MAPKAPK5SPNS10.7251404
MAPKAPK5RBM410.725044303
MAPKAPK5PSIP10.723456303

For details and further investigation, click here