| Full name: proteasome subunit alpha 1 | Alias Symbol: HC2|NU|PROS30|MGC14542|MGC14575|MGC14751|MGC1667|MGC21459|MGC22853|MGC23915 | ||
| Type: protein-coding gene | Cytoband: 11p15.2 | ||
| Entrez ID: 5682 | HGNC ID: HGNC:9530 | Ensembl Gene: ENSG00000129084 | OMIM ID: 602854 |
| Drug and gene relationship at DGIdb | |||
Expression of PSMA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSMA1 | 5682 | 211746_x_at | 0.3827 | 0.1500 | |
| GSE20347 | PSMA1 | 5682 | 211746_x_at | 0.4056 | 0.0241 | |
| GSE23400 | PSMA1 | 5682 | 211746_x_at | 0.5516 | 0.0000 | |
| GSE26886 | PSMA1 | 5682 | 211746_x_at | 0.0970 | 0.6468 | |
| GSE29001 | PSMA1 | 5682 | 201676_x_at | 0.3559 | 0.2704 | |
| GSE38129 | PSMA1 | 5682 | 211746_x_at | 0.4946 | 0.0001 | |
| GSE45670 | PSMA1 | 5682 | 211746_x_at | 0.3402 | 0.0124 | |
| GSE53622 | PSMA1 | 5682 | 98118 | 0.3790 | 0.0000 | |
| GSE53624 | PSMA1 | 5682 | 98118 | 0.6394 | 0.0000 | |
| GSE63941 | PSMA1 | 5682 | 211746_x_at | 0.2067 | 0.5433 | |
| GSE77861 | PSMA1 | 5682 | 201676_x_at | 0.7694 | 0.0421 | |
| GSE97050 | PSMA1 | 5682 | A_23_P150286 | 0.3384 | 0.1663 | |
| SRP007169 | PSMA1 | 5682 | RNAseq | 0.0542 | 0.8923 | |
| SRP008496 | PSMA1 | 5682 | RNAseq | 0.1231 | 0.5891 | |
| SRP064894 | PSMA1 | 5682 | RNAseq | 0.2017 | 0.0773 | |
| SRP133303 | PSMA1 | 5682 | RNAseq | 1.2619 | 0.0005 | |
| SRP159526 | PSMA1 | 5682 | RNAseq | 0.0313 | 0.8937 | |
| SRP193095 | PSMA1 | 5682 | RNAseq | 0.1152 | 0.3155 | |
| SRP219564 | PSMA1 | 5682 | RNAseq | 0.4107 | 0.1014 | |
| TCGA | PSMA1 | 5682 | RNAseq | 0.1565 | 0.0005 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PSMA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PSMA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSMA1 | 5682 | 1 | 10 | 19 | |
| GSE20123 | PSMA1 | 5682 | 1 | 10 | 19 | |
| GSE43470 | PSMA1 | 5682 | 1 | 5 | 37 | |
| GSE46452 | PSMA1 | 5682 | 7 | 5 | 47 | |
| GSE47630 | PSMA1 | 5682 | 3 | 11 | 26 | |
| GSE54993 | PSMA1 | 5682 | 3 | 1 | 66 | |
| GSE54994 | PSMA1 | 5682 | 5 | 11 | 37 | |
| GSE60625 | PSMA1 | 5682 | 0 | 0 | 11 | |
| GSE74703 | PSMA1 | 5682 | 1 | 3 | 32 | |
| GSE74704 | PSMA1 | 5682 | 0 | 9 | 11 | |
| TCGA | PSMA1 | 5682 | 12 | 31 | 53 |
Total number of gains: 34; Total number of losses: 96; Total Number of normals: 358.
Somatic mutations of PSMA1:
Generating mutation plots.
Highly correlated genes for PSMA1:
Showing top 20/1439 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSMA1 | ERP29 | 0.714134 | 3 | 0 | 3 |
| PSMA1 | XRN1 | 0.708442 | 3 | 0 | 3 |
| PSMA1 | SRC | 0.702869 | 3 | 0 | 3 |
| PSMA1 | RBMX | 0.70218 | 3 | 0 | 3 |
| PSMA1 | TMED2 | 0.698489 | 3 | 0 | 3 |
| PSMA1 | TERF2IP | 0.695094 | 4 | 0 | 3 |
| PSMA1 | PLXND1 | 0.691515 | 4 | 0 | 3 |
| PSMA1 | CCT4 | 0.690015 | 11 | 0 | 10 |
| PSMA1 | WDR81 | 0.688428 | 3 | 0 | 3 |
| PSMA1 | RRAS2 | 0.683843 | 9 | 0 | 8 |
| PSMA1 | DNAJB11 | 0.683001 | 6 | 0 | 6 |
| PSMA1 | SAAL1 | 0.680437 | 7 | 0 | 7 |
| PSMA1 | SASS6 | 0.679899 | 3 | 0 | 3 |
| PSMA1 | B3GALT6 | 0.675927 | 5 | 0 | 5 |
| PSMA1 | TMEM189 | 0.670732 | 3 | 0 | 3 |
| PSMA1 | NCBP1 | 0.669863 | 9 | 0 | 7 |
| PSMA1 | PFDN2 | 0.668383 | 11 | 0 | 11 |
| PSMA1 | NONO | 0.667867 | 9 | 0 | 8 |
| PSMA1 | MRPL32 | 0.667737 | 5 | 0 | 5 |
| PSMA1 | TMEM184B | 0.666785 | 7 | 0 | 7 |
For details and further investigation, click here
