| Full name: transmembrane protein 189 | Alias Symbol: Kua | ||
| Type: protein-coding gene | Cytoband: 20q13.13 | ||
| Entrez ID: 387521 | HGNC ID: HGNC:16735 | Ensembl Gene: ENSG00000240849 | OMIM ID: 610994 |
| Drug and gene relationship at DGIdb | |||
Expression of TMEM189:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | TMEM189 | 387521 | 86839 | 0.4690 | 0.0000 | |
| GSE53624 | TMEM189 | 387521 | 67122 | 0.6612 | 0.0000 | |
| GSE97050 | TMEM189 | 387521 | A_33_P3259801 | 0.1613 | 0.6008 | |
| SRP007169 | TMEM189 | 387521 | RNAseq | -0.5935 | 0.1851 | |
| SRP008496 | TMEM189 | 387521 | RNAseq | -0.2347 | 0.3795 | |
| SRP064894 | TMEM189 | 387521 | RNAseq | 0.4756 | 0.0431 | |
| SRP133303 | TMEM189 | 387521 | RNAseq | 0.7546 | 0.0000 | |
| SRP159526 | TMEM189 | 387521 | RNAseq | 0.4918 | 0.0526 | |
| SRP193095 | TMEM189 | 387521 | RNAseq | 0.5700 | 0.0007 | |
| SRP219564 | TMEM189 | 387521 | RNAseq | 0.7066 | 0.0247 | |
| TCGA | TMEM189 | 387521 | RNAseq | 0.4158 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TMEM189 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMEM189:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMEM189 | 387521 | 17 | 2 | 11 | |
| GSE20123 | TMEM189 | 387521 | 17 | 2 | 11 | |
| GSE43470 | TMEM189 | 387521 | 13 | 0 | 30 | |
| GSE46452 | TMEM189 | 387521 | 29 | 0 | 30 | |
| GSE47630 | TMEM189 | 387521 | 24 | 1 | 15 | |
| GSE54993 | TMEM189 | 387521 | 0 | 17 | 53 | |
| GSE54994 | TMEM189 | 387521 | 27 | 0 | 26 | |
| GSE60625 | TMEM189 | 387521 | 0 | 0 | 11 | |
| GSE74703 | TMEM189 | 387521 | 11 | 0 | 25 | |
| GSE74704 | TMEM189 | 387521 | 13 | 0 | 7 | |
| TCGA | TMEM189 | 387521 | 47 | 3 | 46 |
Total number of gains: 198; Total number of losses: 25; Total Number of normals: 265.
Somatic mutations of TMEM189:
Generating mutation plots.
Highly correlated genes for TMEM189:
Showing top 20/133 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMEM189 | PSMG3 | 0.750241 | 3 | 0 | 3 |
| TMEM189 | CSNK1G2 | 0.744059 | 3 | 0 | 3 |
| TMEM189 | PSMD2 | 0.740473 | 3 | 0 | 3 |
| TMEM189 | TNK1 | 0.739145 | 3 | 0 | 3 |
| TMEM189 | SLC35C2 | 0.726307 | 3 | 0 | 3 |
| TMEM189 | TTC4 | 0.725391 | 3 | 0 | 3 |
| TMEM189 | GSS | 0.72508 | 3 | 0 | 3 |
| TMEM189 | CEP85 | 0.722236 | 3 | 0 | 3 |
| TMEM189 | TBRG4 | 0.720468 | 3 | 0 | 3 |
| TMEM189 | MRPS15 | 0.720097 | 3 | 0 | 3 |
| TMEM189 | EIF4G1 | 0.71995 | 3 | 0 | 3 |
| TMEM189 | PCYT1A | 0.719846 | 3 | 0 | 3 |
| TMEM189 | POLR2G | 0.719412 | 3 | 0 | 3 |
| TMEM189 | MRPL17 | 0.719098 | 3 | 0 | 3 |
| TMEM189 | DDX56 | 0.717985 | 3 | 0 | 3 |
| TMEM189 | ALG3 | 0.71253 | 3 | 0 | 3 |
| TMEM189 | ABCF3 | 0.711443 | 3 | 0 | 3 |
| TMEM189 | CSE1L | 0.704863 | 3 | 0 | 3 |
| TMEM189 | EBNA1BP2 | 0.701473 | 3 | 0 | 3 |
| TMEM189 | UBE2C | 0.70147 | 3 | 0 | 3 |
For details and further investigation, click here
