| Full name: transmembrane p24 trafficking protein 2 | Alias Symbol: RNP24|P24A|p24beta1|p24b1 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 10959 | HGNC ID: HGNC:16996 | Ensembl Gene: ENSG00000086598 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of TMED2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMED2 | 10959 | 200087_s_at | 0.1851 | 0.5532 | |
| GSE20347 | TMED2 | 10959 | 200087_s_at | -0.1455 | 0.2530 | |
| GSE23400 | TMED2 | 10959 | 200087_s_at | 0.1304 | 0.0239 | |
| GSE26886 | TMED2 | 10959 | 200087_s_at | -0.5538 | 0.0015 | |
| GSE29001 | TMED2 | 10959 | 200087_s_at | -0.1893 | 0.3489 | |
| GSE38129 | TMED2 | 10959 | 200087_s_at | 0.0143 | 0.9020 | |
| GSE45670 | TMED2 | 10959 | 200087_s_at | 0.1107 | 0.1783 | |
| GSE53622 | TMED2 | 10959 | 9712 | -0.1094 | 0.0483 | |
| GSE53624 | TMED2 | 10959 | 9712 | 0.0110 | 0.8585 | |
| GSE63941 | TMED2 | 10959 | 200087_s_at | -0.5385 | 0.0218 | |
| GSE77861 | TMED2 | 10959 | 200087_s_at | -0.0800 | 0.5190 | |
| GSE97050 | TMED2 | 10959 | A_33_P3301174 | 0.1632 | 0.5990 | |
| SRP007169 | TMED2 | 10959 | RNAseq | -1.0051 | 0.0005 | |
| SRP008496 | TMED2 | 10959 | RNAseq | -0.8525 | 0.0000 | |
| SRP064894 | TMED2 | 10959 | RNAseq | 0.0088 | 0.9609 | |
| SRP133303 | TMED2 | 10959 | RNAseq | 0.2409 | 0.0998 | |
| SRP159526 | TMED2 | 10959 | RNAseq | 0.1949 | 0.3618 | |
| SRP193095 | TMED2 | 10959 | RNAseq | -0.3480 | 0.0053 | |
| SRP219564 | TMED2 | 10959 | RNAseq | -0.1603 | 0.4984 | |
| TCGA | TMED2 | 10959 | RNAseq | -0.0155 | 0.6895 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TMED2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMED2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMED2 | 10959 | 5 | 5 | 20 | |
| GSE20123 | TMED2 | 10959 | 5 | 5 | 20 | |
| GSE43470 | TMED2 | 10959 | 2 | 1 | 40 | |
| GSE46452 | TMED2 | 10959 | 9 | 1 | 49 | |
| GSE47630 | TMED2 | 10959 | 9 | 3 | 28 | |
| GSE54993 | TMED2 | 10959 | 0 | 5 | 65 | |
| GSE54994 | TMED2 | 10959 | 4 | 8 | 41 | |
| GSE60625 | TMED2 | 10959 | 0 | 0 | 11 | |
| GSE74703 | TMED2 | 10959 | 2 | 0 | 34 | |
| GSE74704 | TMED2 | 10959 | 3 | 3 | 14 | |
| TCGA | TMED2 | 10959 | 21 | 11 | 64 |
Total number of gains: 60; Total number of losses: 42; Total Number of normals: 386.
Somatic mutations of TMED2:
Generating mutation plots.
Highly correlated genes for TMED2:
Showing top 20/670 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMED2 | HNRNPF | 0.816989 | 3 | 0 | 3 |
| TMED2 | PALB2 | 0.807376 | 3 | 0 | 3 |
| TMED2 | INTS9 | 0.784635 | 3 | 0 | 3 |
| TMED2 | AHCY | 0.77114 | 4 | 0 | 4 |
| TMED2 | RPL19 | 0.761902 | 3 | 0 | 3 |
| TMED2 | MRPL51 | 0.760659 | 3 | 0 | 3 |
| TMED2 | ZNF217 | 0.755371 | 4 | 0 | 4 |
| TMED2 | NAA20 | 0.755263 | 3 | 0 | 3 |
| TMED2 | SMURF1 | 0.743424 | 3 | 0 | 3 |
| TMED2 | ZNF578 | 0.736339 | 3 | 0 | 3 |
| TMED2 | BET1 | 0.734224 | 5 | 0 | 5 |
| TMED2 | ZNF709 | 0.732069 | 3 | 0 | 3 |
| TMED2 | INTS10 | 0.731781 | 4 | 0 | 4 |
| TMED2 | LRIF1 | 0.728482 | 3 | 0 | 3 |
| TMED2 | SIKE1 | 0.725505 | 3 | 0 | 3 |
| TMED2 | PIGU | 0.72315 | 3 | 0 | 3 |
| TMED2 | WDR73 | 0.71788 | 3 | 0 | 3 |
| TMED2 | UHRF1BP1L | 0.715839 | 3 | 0 | 3 |
| TMED2 | ESYT2 | 0.714405 | 3 | 0 | 3 |
| TMED2 | ZCCHC9 | 0.710224 | 3 | 0 | 3 |
For details and further investigation, click here
