| Full name: chaperonin containing TCP1 subunit 4 | Alias Symbol: Cctd | ||
| Type: protein-coding gene | Cytoband: 2p15 | ||
| Entrez ID: 10575 | HGNC ID: HGNC:1617 | Ensembl Gene: ENSG00000115484 | OMIM ID: 605142 |
| Drug and gene relationship at DGIdb | |||
Expression of CCT4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCT4 | 10575 | 200877_at | 0.6179 | 0.1259 | |
| GSE20347 | CCT4 | 10575 | 200877_at | 0.6812 | 0.0049 | |
| GSE23400 | CCT4 | 10575 | 200877_at | 0.7171 | 0.0000 | |
| GSE26886 | CCT4 | 10575 | 200877_at | 0.1687 | 0.2887 | |
| GSE29001 | CCT4 | 10575 | 200877_at | 0.4126 | 0.3170 | |
| GSE38129 | CCT4 | 10575 | 200877_at | 0.8056 | 0.0000 | |
| GSE45670 | CCT4 | 10575 | 200877_at | 0.4110 | 0.0267 | |
| GSE53622 | CCT4 | 10575 | 90997 | 0.5522 | 0.0000 | |
| GSE53624 | CCT4 | 10575 | 90997 | 0.6386 | 0.0000 | |
| GSE63941 | CCT4 | 10575 | 200877_at | 0.9270 | 0.0032 | |
| GSE77861 | CCT4 | 10575 | 200877_at | 0.6652 | 0.0035 | |
| GSE97050 | CCT4 | 10575 | A_23_P102420 | 0.3956 | 0.2726 | |
| SRP007169 | CCT4 | 10575 | RNAseq | 0.5277 | 0.0705 | |
| SRP008496 | CCT4 | 10575 | RNAseq | 0.5887 | 0.0066 | |
| SRP064894 | CCT4 | 10575 | RNAseq | 0.4381 | 0.0143 | |
| SRP133303 | CCT4 | 10575 | RNAseq | 0.6459 | 0.0000 | |
| SRP159526 | CCT4 | 10575 | RNAseq | 0.7839 | 0.0009 | |
| SRP193095 | CCT4 | 10575 | RNAseq | 0.3361 | 0.0247 | |
| SRP219564 | CCT4 | 10575 | RNAseq | 0.2544 | 0.4125 | |
| TCGA | CCT4 | 10575 | RNAseq | 0.1694 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CCT4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCT4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCT4 | 10575 | 12 | 0 | 18 | |
| GSE20123 | CCT4 | 10575 | 12 | 0 | 18 | |
| GSE43470 | CCT4 | 10575 | 7 | 0 | 36 | |
| GSE46452 | CCT4 | 10575 | 2 | 3 | 54 | |
| GSE47630 | CCT4 | 10575 | 8 | 0 | 32 | |
| GSE54993 | CCT4 | 10575 | 0 | 6 | 64 | |
| GSE54994 | CCT4 | 10575 | 12 | 0 | 41 | |
| GSE60625 | CCT4 | 10575 | 0 | 3 | 8 | |
| GSE74703 | CCT4 | 10575 | 7 | 0 | 29 | |
| GSE74704 | CCT4 | 10575 | 10 | 0 | 10 | |
| TCGA | CCT4 | 10575 | 36 | 2 | 58 |
Total number of gains: 106; Total number of losses: 14; Total Number of normals: 368.
Somatic mutations of CCT4:
Generating mutation plots.
Highly correlated genes for CCT4:
Showing top 20/2018 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCT4 | ILF2 | 0.817921 | 11 | 0 | 11 |
| CCT4 | RAB2B | 0.773515 | 3 | 0 | 3 |
| CCT4 | RANBP1 | 0.764739 | 10 | 0 | 9 |
| CCT4 | XPO1 | 0.763157 | 13 | 0 | 12 |
| CCT4 | EBNA1BP2 | 0.756908 | 3 | 0 | 3 |
| CCT4 | PDIA6 | 0.755723 | 10 | 0 | 9 |
| CCT4 | NIPA1 | 0.75171 | 4 | 0 | 4 |
| CCT4 | HSPD1 | 0.751439 | 11 | 0 | 10 |
| CCT4 | TUBA1B | 0.750898 | 8 | 0 | 8 |
| CCT4 | CHCHD2 | 0.750662 | 9 | 0 | 9 |
| CCT4 | CCT7 | 0.748994 | 12 | 0 | 10 |
| CCT4 | PRELID1 | 0.743159 | 3 | 0 | 3 |
| CCT4 | ZDHHC16 | 0.739447 | 5 | 0 | 5 |
| CCT4 | PRMT1 | 0.73732 | 11 | 0 | 11 |
| CCT4 | STARD7 | 0.735777 | 11 | 0 | 11 |
| CCT4 | ANAPC1 | 0.735012 | 3 | 0 | 3 |
| CCT4 | CCDC117 | 0.733277 | 4 | 0 | 4 |
| CCT4 | IMP4 | 0.732109 | 11 | 0 | 11 |
| CCT4 | MSH2 | 0.731713 | 12 | 0 | 12 |
| CCT4 | INO80E | 0.730927 | 3 | 0 | 3 |
For details and further investigation, click here
