RRAS2

 

Full name: RAS related 2 Alias Symbol: TC21
Type: protein-coding gene Cytoband: 11p15.2
Entrez ID: 22800 HGNC ID: HGNC:17271 Ensembl Gene: ENSG00000133818 OMIM ID: 600098
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

RRAS2 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04024cAMP signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04530Tight junction
hsa04810Regulation of actin cytoskeleton
hsa05166HTLV-I infection
hsa05205Proteoglycans in cancer

 

Expression of RRAS2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RRAS2 22800 212589_at 0.7270 0.0770
GSE20347 RRAS2 22800 212589_at 0.6048 0.0425
GSE23400 RRAS2 22800 212589_at 0.8592 0.0000
GSE26886 RRAS2 22800 212589_at 1.0969 0.0001
GSE29001 RRAS2 22800 212589_at 1.1269 0.0002
GSE38129 RRAS2 22800 212589_at 0.4832 0.0185
GSE45670 RRAS2 22800 212589_at 0.5085 0.0579
GSE63941 RRAS2 22800 212589_at -1.2634 0.0128
GSE77861 RRAS2 22800 212589_at 1.4563 0.0166
GSE97050 RRAS2 22800 A_33_P3297245 0.3287 0.3693
SRP007169 RRAS2 22800 RNAseq 0.5549 0.2692
SRP008496 RRAS2 22800 RNAseq 0.8048 0.0035
SRP064894 RRAS2 22800 RNAseq 0.3032 0.1105
SRP133303 RRAS2 22800 RNAseq 1.5781 0.0000
SRP159526 RRAS2 22800 RNAseq 0.3921 0.3339
SRP193095 RRAS2 22800 RNAseq 0.6367 0.0001
SRP219564 RRAS2 22800 RNAseq 0.4219 0.2127
TCGA RRAS2 22800 RNAseq 0.1755 0.0044

Upregulated datasets: 4; Downregulated datasets: 1.  

 

Survival by RRAS2 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of RRAS2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RRAS2 22800 1 10 19
GSE20123 RRAS2 22800 1 10 19
GSE43470 RRAS2 22800 1 5 37
GSE46452 RRAS2 22800 7 5 47
GSE47630 RRAS2 22800 3 11 26
GSE54993 RRAS2 22800 3 1 66
GSE54994 RRAS2 22800 4 12 37
GSE60625 RRAS2 22800 0 0 11
GSE74703 RRAS2 22800 1 3 32
GSE74704 RRAS2 22800 0 9 11
TCGA RRAS2 22800 12 31 53

Total number of gains: 33; Total number of losses: 97; Total Number of normals: 358.  

 

Somatic mutations of RRAS2:

 

Generating mutation plots.

 

Highly correlated genes for RRAS2:

 

Showing top 20/1185 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RRAS2SOCS70.816707303
RRAS2TRIM350.796517303
RRAS2PLEKHM30.780474303
RRAS2A4GALT0.772843303
RRAS2RBM220.771551303
RRAS2RBM180.768978303
RRAS2RNASEH2C0.768725303
RRAS2NOSIP0.767506303
RRAS2NAPEPLD0.760948303
RRAS2IFFO20.760238303
RRAS2PRTFDC10.760193303
RRAS2ARL13B0.758747403
RRAS2YWHAG0.758023505
RRAS2KLC10.75681303
RRAS2MASTL0.753817303
RRAS2TNPO10.751608303
RRAS2RRM2B0.749412303
RRAS2CTR90.74824303
RRAS2BHLHE410.747592303
RRAS2ZNF354A0.742538404

For details and further investigation, click here