| Full name: 5'-3' exoribonuclease 1 | Alias Symbol: SEP1 | ||
| Type: protein-coding gene | Cytoband: 3q23 | ||
| Entrez ID: 54464 | HGNC ID: HGNC:30654 | Ensembl Gene: ENSG00000114127 | OMIM ID: 607994 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of XRN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | XRN1 | 54464 | 225814_at | 0.4200 | 0.1557 | |
| GSE26886 | XRN1 | 54464 | 225814_at | -0.4381 | 0.0314 | |
| GSE45670 | XRN1 | 54464 | 225814_at | 0.1049 | 0.5999 | |
| GSE53622 | XRN1 | 54464 | 150505 | -0.0719 | 0.3734 | |
| GSE53624 | XRN1 | 54464 | 150505 | 0.0452 | 0.4930 | |
| GSE63941 | XRN1 | 54464 | 225814_at | -0.5368 | 0.2287 | |
| GSE77861 | XRN1 | 54464 | 225814_at | 0.2834 | 0.4426 | |
| GSE97050 | XRN1 | 54464 | A_23_P319792 | -0.0036 | 0.9918 | |
| SRP007169 | XRN1 | 54464 | RNAseq | 0.7904 | 0.0173 | |
| SRP008496 | XRN1 | 54464 | RNAseq | 0.9097 | 0.0000 | |
| SRP064894 | XRN1 | 54464 | RNAseq | -0.1065 | 0.6880 | |
| SRP133303 | XRN1 | 54464 | RNAseq | 0.4066 | 0.0082 | |
| SRP159526 | XRN1 | 54464 | RNAseq | 0.2002 | 0.6830 | |
| SRP193095 | XRN1 | 54464 | RNAseq | 0.1119 | 0.2738 | |
| SRP219564 | XRN1 | 54464 | RNAseq | 0.2872 | 0.5214 | |
| TCGA | XRN1 | 54464 | RNAseq | 0.1129 | 0.0520 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by XRN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of XRN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | XRN1 | 54464 | 21 | 0 | 9 | |
| GSE20123 | XRN1 | 54464 | 21 | 0 | 9 | |
| GSE43470 | XRN1 | 54464 | 22 | 0 | 21 | |
| GSE46452 | XRN1 | 54464 | 15 | 4 | 40 | |
| GSE47630 | XRN1 | 54464 | 19 | 3 | 18 | |
| GSE54993 | XRN1 | 54464 | 1 | 8 | 61 | |
| GSE54994 | XRN1 | 54464 | 34 | 1 | 18 | |
| GSE60625 | XRN1 | 54464 | 0 | 6 | 5 | |
| GSE74703 | XRN1 | 54464 | 19 | 0 | 17 | |
| GSE74704 | XRN1 | 54464 | 14 | 0 | 6 | |
| TCGA | XRN1 | 54464 | 63 | 4 | 29 |
Total number of gains: 229; Total number of losses: 26; Total Number of normals: 233.
Somatic mutations of XRN1:
Generating mutation plots.
Highly correlated genes for XRN1:
Showing top 20/176 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| XRN1 | HMBOX1 | 0.799145 | 3 | 0 | 3 |
| XRN1 | NCBP2 | 0.79888 | 3 | 0 | 3 |
| XRN1 | TFDP2 | 0.792976 | 3 | 0 | 3 |
| XRN1 | CCDC85C | 0.788301 | 3 | 0 | 3 |
| XRN1 | SGSH | 0.781694 | 3 | 0 | 3 |
| XRN1 | CXCL16 | 0.781016 | 3 | 0 | 3 |
| XRN1 | ZNF121 | 0.766449 | 3 | 0 | 3 |
| XRN1 | FASTKD3 | 0.765905 | 3 | 0 | 3 |
| XRN1 | SLC33A1 | 0.75139 | 3 | 0 | 3 |
| XRN1 | HLTF | 0.75094 | 3 | 0 | 3 |
| XRN1 | ZNF623 | 0.746674 | 3 | 0 | 3 |
| XRN1 | U2SURP | 0.735739 | 3 | 0 | 3 |
| XRN1 | ABCF3 | 0.735391 | 3 | 0 | 3 |
| XRN1 | BLCAP | 0.726797 | 3 | 0 | 3 |
| XRN1 | ACAD9 | 0.72474 | 3 | 0 | 3 |
| XRN1 | RXRA | 0.724459 | 3 | 0 | 3 |
| XRN1 | NIT2 | 0.723469 | 3 | 0 | 3 |
| XRN1 | GPR160 | 0.72322 | 3 | 0 | 3 |
| XRN1 | ACAP2 | 0.723019 | 3 | 0 | 3 |
| XRN1 | PCCB | 0.722508 | 3 | 0 | 3 |
For details and further investigation, click here
