PTEN

 

Full name: phosphatase and tensin homolog Alias Symbol: MMAC1|TEP1|PTEN1
Type: protein-coding gene Cytoband: 10q23.31
Entrez ID: 5728 HGNC ID: HGNC:9588 Ensembl Gene: ENSG00000171862 OMIM ID: 601728
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 5/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

PTEN involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04115p53 signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion
hsa04530Tight junction
hsa04931Insulin resistance
hsa05161Hepatitis B
hsa05200Pathways in cancer
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05222Small cell lung cancer

 

Expression of PTEN:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PTEN 5728 225363_at -0.3734 0.1474
GSE20347 PTEN 5728 204053_x_at -0.5274 0.0002
GSE23400 PTEN 5728 204053_x_at -0.2329 0.0045
GSE26886 PTEN 5728 225363_at -0.7312 0.0002
GSE29001 PTEN 5728 204053_x_at -0.7042 0.0718
GSE38129 PTEN 5728 204053_x_at -0.4472 0.0010
GSE45670 PTEN 5728 225363_at -0.3434 0.0156
GSE53622 PTEN 5728 24595 -0.4517 0.0000
GSE53624 PTEN 5728 24595 -0.5071 0.0000
GSE63941 PTEN 5728 204053_x_at 0.2547 0.5485
GSE77861 PTEN 5728 225363_at -0.3141 0.0883
GSE97050 PTEN 5728 A_23_P98085 -0.1707 0.4920
SRP007169 PTEN 5728 RNAseq -1.4445 0.0000
SRP008496 PTEN 5728 RNAseq -0.8702 0.0002
SRP064894 PTEN 5728 RNAseq -0.2975 0.1103
SRP133303 PTEN 5728 RNAseq 0.0639 0.6506
SRP159526 PTEN 5728 RNAseq -0.5664 0.0313
SRP193095 PTEN 5728 RNAseq -0.4900 0.0000
SRP219564 PTEN 5728 RNAseq -0.5202 0.0649
TCGA PTEN 5728 RNAseq -0.1230 0.0056

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by PTEN expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PTEN:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PTEN 5728 2 7 21
GSE20123 PTEN 5728 2 6 22
GSE43470 PTEN 5728 0 9 34
GSE46452 PTEN 5728 0 11 48
GSE47630 PTEN 5728 2 14 24
GSE54993 PTEN 5728 7 0 63
GSE54994 PTEN 5728 1 11 41
GSE60625 PTEN 5728 0 0 11
GSE74703 PTEN 5728 0 7 29
GSE74704 PTEN 5728 1 4 15
TCGA PTEN 5728 6 30 60

Total number of gains: 21; Total number of losses: 99; Total Number of normals: 368.  

 

Somatic mutations of PTEN:

 

Generating mutation plots.

 

Highly correlated genes for PTEN:

 

Showing top 20/967 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PTENZMPSTE240.739555303
PTENZNF4160.7241303
PTENAXL0.718017303
PTENGRHPR0.716537303
PTENFAM160B10.71261303
PTENATP6V0D10.696525404
PTENKLHDC8B0.694906404
PTENGNPDA20.692526404
PTENBLOC1S20.690018403
PTENSAMD9L0.689992303
PTENMIER10.68825606
PTENRNF144B0.683428303
PTENPTPRB0.678193403
PTENRCAN20.677799504
PTENERI20.675524303
PTENDNAJB90.674428403
PTENZNF4360.672191404
PTENDNAJC240.670028303
PTENEGR10.670025303
PTENCTSO0.669796404

For details and further investigation, click here