| Full name: signal peptide, CUB domain and EGF like domain containing 3 | Alias Symbol: FLJ34743 | ||
| Type: protein-coding gene | Cytoband: 6p21.3 | ||
| Entrez ID: 222663 | HGNC ID: HGNC:13655 | Ensembl Gene: ENSG00000146197 | OMIM ID: 614708 |
| Drug and gene relationship at DGIdb | |||
Expression of SCUBE3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCUBE3 | 222663 | 230290_at | -0.1662 | 0.6752 | |
| GSE20347 | SCUBE3 | 222663 | 217600_at | -0.0231 | 0.8399 | |
| GSE23400 | SCUBE3 | 222663 | 217600_at | -0.1390 | 0.0008 | |
| GSE26886 | SCUBE3 | 222663 | 230290_at | 0.3413 | 0.0115 | |
| GSE29001 | SCUBE3 | 222663 | 217600_at | -0.0362 | 0.8744 | |
| GSE38129 | SCUBE3 | 222663 | 217600_at | -0.2511 | 0.0094 | |
| GSE45670 | SCUBE3 | 222663 | 228407_at | 0.1896 | 0.8156 | |
| GSE53622 | SCUBE3 | 222663 | 155579 | 0.3075 | 0.2295 | |
| GSE53624 | SCUBE3 | 222663 | 155579 | 0.5665 | 0.0007 | |
| GSE63941 | SCUBE3 | 222663 | 228407_at | -4.5837 | 0.0000 | |
| GSE77861 | SCUBE3 | 222663 | 230253_at | -0.0785 | 0.5208 | |
| GSE97050 | SCUBE3 | 222663 | A_24_P943894 | -0.3132 | 0.2832 | |
| SRP007169 | SCUBE3 | 222663 | RNAseq | 3.2439 | 0.0000 | |
| SRP008496 | SCUBE3 | 222663 | RNAseq | 3.8740 | 0.0000 | |
| SRP064894 | SCUBE3 | 222663 | RNAseq | 0.6940 | 0.0242 | |
| SRP133303 | SCUBE3 | 222663 | RNAseq | 0.0291 | 0.8838 | |
| SRP159526 | SCUBE3 | 222663 | RNAseq | 1.9828 | 0.0057 | |
| SRP193095 | SCUBE3 | 222663 | RNAseq | 1.1264 | 0.0000 | |
| SRP219564 | SCUBE3 | 222663 | RNAseq | 0.2992 | 0.6434 | |
| TCGA | SCUBE3 | 222663 | RNAseq | -0.2873 | 0.3768 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by SCUBE3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCUBE3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCUBE3 | 222663 | 5 | 0 | 25 | |
| GSE20123 | SCUBE3 | 222663 | 5 | 0 | 25 | |
| GSE43470 | SCUBE3 | 222663 | 6 | 1 | 36 | |
| GSE46452 | SCUBE3 | 222663 | 2 | 9 | 48 | |
| GSE47630 | SCUBE3 | 222663 | 8 | 4 | 28 | |
| GSE54993 | SCUBE3 | 222663 | 3 | 1 | 66 | |
| GSE54994 | SCUBE3 | 222663 | 11 | 4 | 38 | |
| GSE60625 | SCUBE3 | 222663 | 1 | 0 | 10 | |
| GSE74703 | SCUBE3 | 222663 | 6 | 0 | 30 | |
| GSE74704 | SCUBE3 | 222663 | 2 | 0 | 18 | |
| TCGA | SCUBE3 | 222663 | 16 | 15 | 65 |
Total number of gains: 65; Total number of losses: 34; Total Number of normals: 389.
Somatic mutations of SCUBE3:
Generating mutation plots.
Highly correlated genes for SCUBE3:
Showing top 20/510 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCUBE3 | ST6GALNAC3 | 0.810389 | 3 | 0 | 3 |
| SCUBE3 | ARHGAP31 | 0.766842 | 3 | 0 | 3 |
| SCUBE3 | PGM5-AS1 | 0.76594 | 3 | 0 | 3 |
| SCUBE3 | ZEB2 | 0.760258 | 3 | 0 | 3 |
| SCUBE3 | MYOCD | 0.753475 | 3 | 0 | 3 |
| SCUBE3 | BDNF | 0.73493 | 5 | 0 | 5 |
| SCUBE3 | C19orf18 | 0.733567 | 3 | 0 | 3 |
| SCUBE3 | FIBIN | 0.727044 | 3 | 0 | 3 |
| SCUBE3 | AKAP12 | 0.722955 | 3 | 0 | 3 |
| SCUBE3 | PTGER2 | 0.712398 | 4 | 0 | 3 |
| SCUBE3 | CCDC169 | 0.70637 | 3 | 0 | 3 |
| SCUBE3 | CYP2U1 | 0.702338 | 3 | 0 | 3 |
| SCUBE3 | DCHS1 | 0.698938 | 4 | 0 | 4 |
| SCUBE3 | C11orf96 | 0.696818 | 4 | 0 | 4 |
| SCUBE3 | STAT5A | 0.692937 | 3 | 0 | 3 |
| SCUBE3 | TFPI | 0.690011 | 3 | 0 | 3 |
| SCUBE3 | SCN4B | 0.68623 | 3 | 0 | 3 |
| SCUBE3 | SYNPO2 | 0.685829 | 3 | 0 | 3 |
| SCUBE3 | EBF1 | 0.681717 | 3 | 0 | 3 |
| SCUBE3 | PRUNE2 | 0.680945 | 4 | 0 | 4 |
For details and further investigation, click here
