INTS3

 

Full name: integrator complex subunit 3 Alias Symbol: FLJ21919|INT3|SOSS-A
Type: protein-coding gene Cytoband: 1q21.3
Entrez ID: 65123 HGNC ID: HGNC:26153 Ensembl Gene: ENSG00000143624 OMIM ID: 611347
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of INTS3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 INTS3 65123 202809_s_at 0.4000 0.3622
GSE20347 INTS3 65123 202809_s_at 0.3822 0.0000
GSE23400 INTS3 65123 202809_s_at 0.1165 0.0725
GSE26886 INTS3 65123 202809_s_at -0.1202 0.4624
GSE29001 INTS3 65123 202809_s_at 0.2020 0.4877
GSE38129 INTS3 65123 202809_s_at 0.1372 0.2458
GSE45670 INTS3 65123 202809_s_at 0.1688 0.2178
GSE63941 INTS3 65123 202809_s_at 0.9580 0.0211
GSE77861 INTS3 65123 202809_s_at 0.3194 0.1198
GSE97050 INTS3 65123 A_23_P126757 0.0162 0.9706
SRP007169 INTS3 65123 RNAseq 0.7966 0.0276
SRP008496 INTS3 65123 RNAseq 0.8176 0.0013
SRP064894 INTS3 65123 RNAseq 0.3236 0.0523
SRP133303 INTS3 65123 RNAseq 0.0351 0.8103
SRP159526 INTS3 65123 RNAseq 0.1696 0.6104
SRP193095 INTS3 65123 RNAseq 0.3208 0.0021
SRP219564 INTS3 65123 RNAseq 0.1517 0.6564
TCGA INTS3 65123 RNAseq -0.0545 0.2125

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by INTS3 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of INTS3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 INTS3 65123 14 0 16
GSE20123 INTS3 65123 14 0 16
GSE43470 INTS3 65123 7 2 34
GSE46452 INTS3 65123 2 1 56
GSE47630 INTS3 65123 14 0 26
GSE54993 INTS3 65123 0 4 66
GSE54994 INTS3 65123 16 0 37
GSE60625 INTS3 65123 0 0 11
GSE74703 INTS3 65123 6 1 29
GSE74704 INTS3 65123 7 0 13
TCGA INTS3 65123 38 3 55

Total number of gains: 118; Total number of losses: 11; Total Number of normals: 359.  

 

Somatic mutations of INTS3:

 

Generating mutation plots.

 

Highly correlated genes for INTS3:

 

Showing top 20/751 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
INTS3TTC7B0.794822303
INTS3PPP1R350.788416303
INTS3TP53I130.783848303
INTS3ARL20.782851303
INTS3UTP230.782679303
INTS3PTK20.760077404
INTS3SLC41A10.758431303
INTS3AKT10.755225404
INTS3RNF1300.75324303
INTS3PDCD2L0.752319303
INTS3ZNF2510.746879303
INTS3DARS20.743084404
INTS3NAPEPLD0.741967303
INTS3TCF7L10.740994404
INTS3XAB20.734934404
INTS3SENP50.734213303
INTS3METAP1D0.733746303
INTS3FAM50A0.730441403
INTS3ADCY30.729764505
INTS3CLASRP0.727156505

For details and further investigation, click here