| Full name: plexin A1 | Alias Symbol: NOV | ||
| Type: protein-coding gene | Cytoband: 3q21.3 | ||
| Entrez ID: 5361 | HGNC ID: HGNC:9099 | Ensembl Gene: ENSG00000114554 | OMIM ID: 601055 |
| Drug and gene relationship at DGIdb | |||
PLXNA1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of PLXNA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLXNA1 | 5361 | 221538_s_at | 1.7853 | 0.0086 | |
| GSE20347 | PLXNA1 | 5361 | 221538_s_at | 1.5667 | 0.0000 | |
| GSE23400 | PLXNA1 | 5361 | 221538_s_at | 1.4726 | 0.0000 | |
| GSE26886 | PLXNA1 | 5361 | 221538_s_at | 2.4463 | 0.0000 | |
| GSE29001 | PLXNA1 | 5361 | 221538_s_at | 1.5857 | 0.0001 | |
| GSE38129 | PLXNA1 | 5361 | 221538_s_at | 1.5345 | 0.0000 | |
| GSE45670 | PLXNA1 | 5361 | 221538_s_at | 1.3473 | 0.0000 | |
| GSE53622 | PLXNA1 | 5361 | 78573 | 1.5976 | 0.0000 | |
| GSE53624 | PLXNA1 | 5361 | 78573 | 1.9149 | 0.0000 | |
| GSE63941 | PLXNA1 | 5361 | 221538_s_at | 0.1775 | 0.8159 | |
| GSE77861 | PLXNA1 | 5361 | 221538_s_at | 1.5769 | 0.0009 | |
| GSE97050 | PLXNA1 | 5361 | A_23_P57667 | 0.7766 | 0.0888 | |
| SRP007169 | PLXNA1 | 5361 | RNAseq | 2.4681 | 0.0000 | |
| SRP008496 | PLXNA1 | 5361 | RNAseq | 2.3505 | 0.0000 | |
| SRP064894 | PLXNA1 | 5361 | RNAseq | 1.8216 | 0.0000 | |
| SRP133303 | PLXNA1 | 5361 | RNAseq | 1.8672 | 0.0000 | |
| SRP159526 | PLXNA1 | 5361 | RNAseq | 2.0325 | 0.0001 | |
| SRP193095 | PLXNA1 | 5361 | RNAseq | 1.9996 | 0.0000 | |
| SRP219564 | PLXNA1 | 5361 | RNAseq | 1.2835 | 0.0028 | |
| TCGA | PLXNA1 | 5361 | RNAseq | 0.3054 | 0.0000 |
Upregulated datasets: 17; Downregulated datasets: 0.
Survival by PLXNA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLXNA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLXNA1 | 5361 | 17 | 0 | 13 | |
| GSE20123 | PLXNA1 | 5361 | 17 | 0 | 13 | |
| GSE43470 | PLXNA1 | 5361 | 19 | 0 | 24 | |
| GSE46452 | PLXNA1 | 5361 | 14 | 5 | 40 | |
| GSE47630 | PLXNA1 | 5361 | 17 | 4 | 19 | |
| GSE54993 | PLXNA1 | 5361 | 2 | 7 | 61 | |
| GSE54994 | PLXNA1 | 5361 | 31 | 3 | 19 | |
| GSE60625 | PLXNA1 | 5361 | 0 | 6 | 5 | |
| GSE74703 | PLXNA1 | 5361 | 17 | 0 | 19 | |
| GSE74704 | PLXNA1 | 5361 | 13 | 0 | 7 | |
| TCGA | PLXNA1 | 5361 | 55 | 6 | 35 |
Total number of gains: 202; Total number of losses: 31; Total Number of normals: 255.
Somatic mutations of PLXNA1:
Generating mutation plots.
Highly correlated genes for PLXNA1:
Showing top 20/2499 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLXNA1 | SLC39A3 | 0.837225 | 4 | 0 | 4 |
| PLXNA1 | U2SURP | 0.826562 | 9 | 0 | 9 |
| PLXNA1 | IPO9 | 0.822717 | 8 | 0 | 8 |
| PLXNA1 | MTBP | 0.820989 | 5 | 0 | 5 |
| PLXNA1 | CMSS1 | 0.819878 | 6 | 0 | 6 |
| PLXNA1 | DNMT1 | 0.816159 | 11 | 0 | 11 |
| PLXNA1 | TCF3 | 0.812841 | 11 | 0 | 11 |
| PLXNA1 | MRPL47 | 0.809594 | 7 | 0 | 7 |
| PLXNA1 | B3GALT6 | 0.805967 | 6 | 0 | 6 |
| PLXNA1 | ALKBH6 | 0.801933 | 5 | 0 | 5 |
| PLXNA1 | AURKAIP1 | 0.80064 | 3 | 0 | 3 |
| PLXNA1 | SIX4 | 0.796442 | 7 | 0 | 7 |
| PLXNA1 | COLGALT1 | 0.796327 | 10 | 0 | 10 |
| PLXNA1 | RPN1 | 0.795929 | 10 | 0 | 10 |
| PLXNA1 | WDR54 | 0.795896 | 6 | 0 | 6 |
| PLXNA1 | LRRC58 | 0.794113 | 5 | 0 | 5 |
| PLXNA1 | KHSRP | 0.791597 | 8 | 0 | 8 |
| PLXNA1 | LAPTM4B | 0.790316 | 11 | 0 | 11 |
| PLXNA1 | FADS1 | 0.789954 | 3 | 0 | 3 |
| PLXNA1 | FNDC3B | 0.788275 | 11 | 0 | 11 |
For details and further investigation, click here
