| Full name: lysosomal protein transmembrane 4 beta | Alias Symbol: LC27 | ||
| Type: protein-coding gene | Cytoband: 8q22.1 | ||
| Entrez ID: 55353 | HGNC ID: HGNC:13646 | Ensembl Gene: ENSG00000104341 | OMIM ID: 613296 |
| Drug and gene relationship at DGIdb | |||
Expression of LAPTM4B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LAPTM4B | 55353 | 214039_s_at | 1.2077 | 0.0680 | |
| GSE20347 | LAPTM4B | 55353 | 214039_s_at | 1.7169 | 0.0000 | |
| GSE23400 | LAPTM4B | 55353 | 214039_s_at | 1.5136 | 0.0000 | |
| GSE26886 | LAPTM4B | 55353 | 214039_s_at | 1.7450 | 0.0000 | |
| GSE29001 | LAPTM4B | 55353 | 214039_s_at | 1.4379 | 0.0001 | |
| GSE38129 | LAPTM4B | 55353 | 214039_s_at | 1.4646 | 0.0000 | |
| GSE45670 | LAPTM4B | 55353 | 214039_s_at | 1.3612 | 0.0000 | |
| GSE53622 | LAPTM4B | 55353 | 114210 | 1.8443 | 0.0000 | |
| GSE53624 | LAPTM4B | 55353 | 114210 | 1.9412 | 0.0000 | |
| GSE63941 | LAPTM4B | 55353 | 214039_s_at | 0.9292 | 0.0357 | |
| GSE77861 | LAPTM4B | 55353 | 214039_s_at | 1.2289 | 0.0208 | |
| GSE97050 | LAPTM4B | 55353 | A_24_P180680 | 1.0754 | 0.1144 | |
| SRP007169 | LAPTM4B | 55353 | RNAseq | 3.1887 | 0.0000 | |
| SRP008496 | LAPTM4B | 55353 | RNAseq | 3.1811 | 0.0000 | |
| SRP064894 | LAPTM4B | 55353 | RNAseq | 1.7719 | 0.0000 | |
| SRP133303 | LAPTM4B | 55353 | RNAseq | 1.4508 | 0.0000 | |
| SRP159526 | LAPTM4B | 55353 | RNAseq | 1.8102 | 0.0000 | |
| SRP193095 | LAPTM4B | 55353 | RNAseq | 1.3635 | 0.0000 | |
| SRP219564 | LAPTM4B | 55353 | RNAseq | 1.1569 | 0.0013 | |
| TCGA | LAPTM4B | 55353 | RNAseq | 0.3041 | 0.0000 |
Upregulated datasets: 16; Downregulated datasets: 0.
Survival by LAPTM4B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LAPTM4B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LAPTM4B | 55353 | 16 | 0 | 14 | |
| GSE20123 | LAPTM4B | 55353 | 17 | 0 | 13 | |
| GSE43470 | LAPTM4B | 55353 | 21 | 1 | 21 | |
| GSE46452 | LAPTM4B | 55353 | 23 | 0 | 36 | |
| GSE47630 | LAPTM4B | 55353 | 24 | 0 | 16 | |
| GSE54993 | LAPTM4B | 55353 | 0 | 20 | 50 | |
| GSE54994 | LAPTM4B | 55353 | 35 | 3 | 15 | |
| GSE60625 | LAPTM4B | 55353 | 0 | 4 | 7 | |
| GSE74703 | LAPTM4B | 55353 | 18 | 1 | 17 | |
| GSE74704 | LAPTM4B | 55353 | 12 | 0 | 8 | |
| TCGA | LAPTM4B | 55353 | 56 | 1 | 39 |
Total number of gains: 222; Total number of losses: 30; Total Number of normals: 236.
Somatic mutations of LAPTM4B:
Generating mutation plots.
Highly correlated genes for LAPTM4B:
Showing top 20/2081 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LAPTM4B | FADS1 | 0.820822 | 3 | 0 | 3 |
| LAPTM4B | SLC25A32 | 0.816601 | 11 | 0 | 11 |
| LAPTM4B | STK3 | 0.815515 | 11 | 0 | 11 |
| LAPTM4B | LPCAT1 | 0.799768 | 11 | 0 | 11 |
| LAPTM4B | B3GALT6 | 0.797733 | 6 | 0 | 6 |
| LAPTM4B | PLXNA1 | 0.790316 | 11 | 0 | 11 |
| LAPTM4B | XPR1 | 0.790118 | 7 | 0 | 7 |
| LAPTM4B | DPY19L4 | 0.789682 | 12 | 0 | 11 |
| LAPTM4B | RAB34 | 0.78914 | 3 | 0 | 3 |
| LAPTM4B | MFAP2 | 0.787986 | 11 | 0 | 11 |
| LAPTM4B | FNDC3B | 0.785849 | 11 | 0 | 11 |
| LAPTM4B | PUF60 | 0.784783 | 11 | 0 | 11 |
| LAPTM4B | SERPINH1 | 0.784161 | 10 | 0 | 10 |
| LAPTM4B | TCF3 | 0.782865 | 11 | 0 | 11 |
| LAPTM4B | PTK2 | 0.780613 | 11 | 0 | 11 |
| LAPTM4B | PTDSS1 | 0.779987 | 12 | 0 | 12 |
| LAPTM4B | TAF2 | 0.779744 | 12 | 0 | 11 |
| LAPTM4B | SNAP47 | 0.778111 | 3 | 0 | 3 |
| LAPTM4B | SPON2 | 0.777074 | 3 | 0 | 3 |
| LAPTM4B | APMAP | 0.77629 | 10 | 0 | 10 |
For details and further investigation, click here
