| Full name: quinoid dihydropteridine reductase | Alias Symbol: DHPR|PKU2|SDR33C1 | ||
| Type: protein-coding gene | Cytoband: 4p15.32 | ||
| Entrez ID: 5860 | HGNC ID: HGNC:9752 | Ensembl Gene: ENSG00000151552 | OMIM ID: 612676 |
| Drug and gene relationship at DGIdb | |||
Expression of QDPR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | QDPR | 5860 | 209123_at | 0.1778 | 0.6428 | |
| GSE20347 | QDPR | 5860 | 209123_at | -0.3101 | 0.0454 | |
| GSE23400 | QDPR | 5860 | 209123_at | 0.0780 | 0.3248 | |
| GSE26886 | QDPR | 5860 | 209123_at | -0.5006 | 0.0652 | |
| GSE29001 | QDPR | 5860 | 209123_at | -0.0476 | 0.9119 | |
| GSE38129 | QDPR | 5860 | 209123_at | -0.1866 | 0.2330 | |
| GSE45670 | QDPR | 5860 | 209123_at | -0.2881 | 0.0905 | |
| GSE53622 | QDPR | 5860 | 84314 | -0.5046 | 0.0001 | |
| GSE53624 | QDPR | 5860 | 84314 | -0.4303 | 0.0000 | |
| GSE63941 | QDPR | 5860 | 209123_at | -1.4346 | 0.0119 | |
| GSE77861 | QDPR | 5860 | 209123_at | -0.6102 | 0.0211 | |
| GSE97050 | QDPR | 5860 | A_33_P3398897 | -0.4993 | 0.1782 | |
| SRP007169 | QDPR | 5860 | RNAseq | -0.1102 | 0.8057 | |
| SRP008496 | QDPR | 5860 | RNAseq | -0.2894 | 0.4371 | |
| SRP064894 | QDPR | 5860 | RNAseq | 0.0030 | 0.9909 | |
| SRP133303 | QDPR | 5860 | RNAseq | -0.4810 | 0.0026 | |
| SRP159526 | QDPR | 5860 | RNAseq | -0.1892 | 0.4385 | |
| SRP193095 | QDPR | 5860 | RNAseq | -0.6346 | 0.0009 | |
| SRP219564 | QDPR | 5860 | RNAseq | 0.0249 | 0.9475 | |
| TCGA | QDPR | 5860 | RNAseq | -0.2192 | 0.0018 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by QDPR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of QDPR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | QDPR | 5860 | 0 | 18 | 12 | |
| GSE20123 | QDPR | 5860 | 0 | 18 | 12 | |
| GSE43470 | QDPR | 5860 | 1 | 15 | 27 | |
| GSE46452 | QDPR | 5860 | 1 | 36 | 22 | |
| GSE47630 | QDPR | 5860 | 1 | 19 | 20 | |
| GSE54993 | QDPR | 5860 | 9 | 0 | 61 | |
| GSE54994 | QDPR | 5860 | 4 | 12 | 37 | |
| GSE60625 | QDPR | 5860 | 0 | 0 | 11 | |
| GSE74703 | QDPR | 5860 | 1 | 13 | 22 | |
| GSE74704 | QDPR | 5860 | 0 | 11 | 9 | |
| TCGA | QDPR | 5860 | 9 | 48 | 39 |
Total number of gains: 26; Total number of losses: 190; Total Number of normals: 272.
Somatic mutations of QDPR:
Generating mutation plots.
Highly correlated genes for QDPR:
Showing top 20/45 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| QDPR | WDR82 | 0.734686 | 3 | 0 | 3 |
| QDPR | PGBD1 | 0.670362 | 3 | 0 | 3 |
| QDPR | CLNS1A | 0.629616 | 5 | 0 | 4 |
| QDPR | ZNF585B | 0.621272 | 5 | 0 | 4 |
| QDPR | EIF3I | 0.578568 | 3 | 0 | 3 |
| QDPR | MAOA | 0.57359 | 4 | 0 | 3 |
| QDPR | AAMDC | 0.562519 | 4 | 0 | 3 |
| QDPR | ZBTB49 | 0.558945 | 4 | 0 | 3 |
| QDPR | APEH | 0.556563 | 5 | 0 | 4 |
| QDPR | TMEM129 | 0.553659 | 5 | 0 | 4 |
| QDPR | NHP2 | 0.553407 | 5 | 0 | 3 |
| QDPR | PAAF1 | 0.552077 | 7 | 0 | 4 |
| QDPR | KLHDC8B | 0.550237 | 4 | 0 | 3 |
| QDPR | SREK1 | 0.545894 | 5 | 0 | 3 |
| QDPR | ZNF506 | 0.543431 | 4 | 0 | 3 |
| QDPR | ZNF83 | 0.535711 | 4 | 0 | 3 |
| QDPR | TK2 | 0.534354 | 5 | 0 | 4 |
| QDPR | CDAN1 | 0.53215 | 3 | 0 | 3 |
| QDPR | LINC00960 | 0.531309 | 4 | 0 | 3 |
| QDPR | ZNF879 | 0.529522 | 5 | 0 | 3 |
For details and further investigation, click here
