| Full name: thymidine kinase 2 | Alias Symbol: SCA31 | ||
| Type: protein-coding gene | Cytoband: 16q21 | ||
| Entrez ID: 7084 | HGNC ID: HGNC:11831 | Ensembl Gene: ENSG00000166548 | OMIM ID: 188250 |
| Drug and gene relationship at DGIdb | |||
Expression of TK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TK2 | 7084 | 204276_at | -0.1507 | 0.7262 | |
| GSE20347 | TK2 | 7084 | 204276_at | -0.2090 | 0.1175 | |
| GSE23400 | TK2 | 7084 | 204227_s_at | -0.0577 | 0.1229 | |
| GSE26886 | TK2 | 7084 | 204276_at | 0.4714 | 0.0023 | |
| GSE29001 | TK2 | 7084 | 204276_at | -0.2248 | 0.3175 | |
| GSE38129 | TK2 | 7084 | 204276_at | -0.2787 | 0.1229 | |
| GSE45670 | TK2 | 7084 | 204276_at | -0.5349 | 0.0098 | |
| GSE63941 | TK2 | 7084 | 204276_at | -2.5890 | 0.0001 | |
| GSE77861 | TK2 | 7084 | 204277_s_at | -0.0974 | 0.4621 | |
| GSE97050 | TK2 | 7084 | A_33_P3392537 | -0.4333 | 0.1389 | |
| SRP007169 | TK2 | 7084 | RNAseq | 0.4090 | 0.3622 | |
| SRP008496 | TK2 | 7084 | RNAseq | 0.9644 | 0.0142 | |
| SRP064894 | TK2 | 7084 | RNAseq | -0.2215 | 0.3193 | |
| SRP133303 | TK2 | 7084 | RNAseq | -0.2700 | 0.0606 | |
| SRP159526 | TK2 | 7084 | RNAseq | -0.0562 | 0.8828 | |
| SRP193095 | TK2 | 7084 | RNAseq | -0.1443 | 0.2451 | |
| SRP219564 | TK2 | 7084 | RNAseq | -0.1679 | 0.6657 | |
| TCGA | TK2 | 7084 | RNAseq | -0.2252 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TK2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of TK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TK2 | 7084 | 7 | 2 | 21 | |
| GSE20123 | TK2 | 7084 | 8 | 2 | 20 | |
| GSE43470 | TK2 | 7084 | 1 | 8 | 34 | |
| GSE46452 | TK2 | 7084 | 38 | 1 | 20 | |
| GSE47630 | TK2 | 7084 | 10 | 8 | 22 | |
| GSE54993 | TK2 | 7084 | 2 | 4 | 64 | |
| GSE54994 | TK2 | 7084 | 8 | 10 | 35 | |
| GSE60625 | TK2 | 7084 | 4 | 0 | 7 | |
| GSE74703 | TK2 | 7084 | 1 | 5 | 30 | |
| GSE74704 | TK2 | 7084 | 5 | 1 | 14 | |
| TCGA | TK2 | 7084 | 30 | 11 | 55 |
Total number of gains: 114; Total number of losses: 52; Total Number of normals: 322.
Somatic mutations of TK2:
Generating mutation plots.
Highly correlated genes for TK2:
Showing top 20/441 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TK2 | ST3GAL2 | 0.82843 | 3 | 0 | 3 |
| TK2 | KLHDC1 | 0.798524 | 3 | 0 | 3 |
| TK2 | ENG | 0.795852 | 4 | 0 | 4 |
| TK2 | DTWD1 | 0.795161 | 3 | 0 | 3 |
| TK2 | ARHGAP31 | 0.793532 | 3 | 0 | 3 |
| TK2 | C11orf96 | 0.785221 | 3 | 0 | 3 |
| TK2 | RTF1 | 0.777805 | 3 | 0 | 3 |
| TK2 | CSF1 | 0.776857 | 3 | 0 | 3 |
| TK2 | PODN | 0.771663 | 3 | 0 | 3 |
| TK2 | DOK6 | 0.770439 | 3 | 0 | 3 |
| TK2 | FMNL3 | 0.756545 | 3 | 0 | 3 |
| TK2 | ANKRD11 | 0.756239 | 3 | 0 | 3 |
| TK2 | ARHGEF6 | 0.756043 | 4 | 0 | 4 |
| TK2 | TNFAIP6 | 0.755952 | 3 | 0 | 3 |
| TK2 | NKAPL | 0.745044 | 3 | 0 | 3 |
| TK2 | PDGFRB | 0.743717 | 4 | 0 | 4 |
| TK2 | ABL2 | 0.742753 | 3 | 0 | 3 |
| TK2 | SWAP70 | 0.741739 | 3 | 0 | 3 |
| TK2 | CRISPLD2 | 0.736788 | 4 | 0 | 4 |
| TK2 | RFTN1 | 0.734384 | 4 | 0 | 4 |
For details and further investigation, click here
