CLNS1A

 

Full name: chloride nucleotide-sensitive channel 1A Alias Symbol: ICln
Type: protein-coding gene Cytoband: 11q14.1
Entrez ID: 1207 HGNC ID: HGNC:2080 Ensembl Gene: ENSG00000074201 OMIM ID: 602158
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of CLNS1A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CLNS1A 1207 209143_s_at 0.1942 0.8064
GSE20347 CLNS1A 1207 209143_s_at 0.4615 0.0205
GSE23400 CLNS1A 1207 209143_s_at 0.5806 0.0000
GSE26886 CLNS1A 1207 209143_s_at -0.1434 0.6050
GSE29001 CLNS1A 1207 209143_s_at 0.1564 0.6145
GSE38129 CLNS1A 1207 209143_s_at 0.6118 0.0001
GSE45670 CLNS1A 1207 209143_s_at 0.3150 0.1610
GSE53622 CLNS1A 1207 57625 0.3643 0.0001
GSE53624 CLNS1A 1207 57625 0.4639 0.0000
GSE63941 CLNS1A 1207 209143_s_at 0.1081 0.8204
GSE77861 CLNS1A 1207 209143_s_at 0.0017 0.9977
GSE97050 CLNS1A 1207 A_23_P127995 0.2405 0.4722
SRP007169 CLNS1A 1207 RNAseq 0.2792 0.5989
SRP008496 CLNS1A 1207 RNAseq 0.2595 0.3664
SRP064894 CLNS1A 1207 RNAseq 0.0514 0.8001
SRP133303 CLNS1A 1207 RNAseq -0.3595 0.0037
SRP159526 CLNS1A 1207 RNAseq -0.1816 0.6370
SRP193095 CLNS1A 1207 RNAseq -0.1991 0.2384
SRP219564 CLNS1A 1207 RNAseq 0.0754 0.8706
TCGA CLNS1A 1207 RNAseq 0.1455 0.0132

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CLNS1A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CLNS1A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CLNS1A 1207 5 9 16
GSE20123 CLNS1A 1207 5 8 17
GSE43470 CLNS1A 1207 3 3 37
GSE46452 CLNS1A 1207 8 21 30
GSE47630 CLNS1A 1207 4 17 19
GSE54993 CLNS1A 1207 8 2 60
GSE54994 CLNS1A 1207 6 17 30
GSE60625 CLNS1A 1207 4 3 4
GSE74703 CLNS1A 1207 2 2 32
GSE74704 CLNS1A 1207 3 4 13
TCGA CLNS1A 1207 21 31 44

Total number of gains: 69; Total number of losses: 117; Total Number of normals: 302.  

 

Somatic mutations of CLNS1A:

 

Generating mutation plots.

 

Highly correlated genes for CLNS1A:

 

Showing top 20/358 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CLNS1AARV10.764046303
CLNS1AALG80.75898313013
CLNS1AFH0.749185303
CLNS1AEXOC80.735701303
CLNS1ASLC40A10.734797303
CLNS1ACEBPZ0.724996303
CLNS1ATATDN20.713231303
CLNS1AZNRF30.703472303
CLNS1AMED170.695686909
CLNS1AINTS40.693574806
CLNS1ANARS20.69334713012
CLNS1ALRRC280.690953303
CLNS1ARPP140.688134303
CLNS1ASNRPD30.684272303
CLNS1AFBXW20.684152303
CLNS1AEED0.6835711109
CLNS1ATADA30.679936303
CLNS1ACREG10.678252303
CLNS1AMAP4K20.67468303
CLNS1AMYC0.668731505

For details and further investigation, click here