| Full name: splicing regulatory glutamic acid and lysine rich protein 1 | Alias Symbol: DKFZp564B176|SRrp86|SRrp508 | ||
| Type: protein-coding gene | Cytoband: 5q12.3 | ||
| Entrez ID: 140890 | HGNC ID: HGNC:17882 | Ensembl Gene: ENSG00000153914 | OMIM ID: 609268 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SREK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SREK1 | 140890 | 212721_at | -0.0187 | 0.9732 | |
| GSE20347 | SREK1 | 140890 | 212721_at | -0.0244 | 0.8657 | |
| GSE23400 | SREK1 | 140890 | 212721_at | 0.2104 | 0.0112 | |
| GSE26886 | SREK1 | 140890 | 212721_at | -0.9870 | 0.0002 | |
| GSE29001 | SREK1 | 140890 | 212721_at | -0.1581 | 0.6143 | |
| GSE38129 | SREK1 | 140890 | 212721_at | 0.0343 | 0.7954 | |
| GSE45670 | SREK1 | 140890 | 212721_at | -0.0904 | 0.3856 | |
| GSE53622 | SREK1 | 140890 | 138345 | 0.0106 | 0.9045 | |
| GSE53624 | SREK1 | 140890 | 138345 | -0.1321 | 0.1430 | |
| GSE63941 | SREK1 | 140890 | 212721_at | -0.8023 | 0.0941 | |
| GSE77861 | SREK1 | 140890 | 212721_at | -0.1909 | 0.4425 | |
| GSE97050 | SREK1 | 140890 | A_24_P191833 | -0.0495 | 0.8339 | |
| SRP007169 | SREK1 | 140890 | RNAseq | 0.5919 | 0.1097 | |
| SRP008496 | SREK1 | 140890 | RNAseq | 0.6809 | 0.0070 | |
| SRP064894 | SREK1 | 140890 | RNAseq | -0.0596 | 0.7697 | |
| SRP133303 | SREK1 | 140890 | RNAseq | -0.1468 | 0.1773 | |
| SRP159526 | SREK1 | 140890 | RNAseq | -0.3581 | 0.0630 | |
| SRP193095 | SREK1 | 140890 | RNAseq | -0.2748 | 0.0129 | |
| SRP219564 | SREK1 | 140890 | RNAseq | -0.3250 | 0.3236 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SREK1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SREK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SREK1 | 140890 | 0 | 13 | 17 | |
| GSE20123 | SREK1 | 140890 | 0 | 13 | 17 | |
| GSE43470 | SREK1 | 140890 | 1 | 12 | 30 | |
| GSE46452 | SREK1 | 140890 | 0 | 28 | 31 | |
| GSE47630 | SREK1 | 140890 | 2 | 17 | 21 | |
| GSE54993 | SREK1 | 140890 | 8 | 1 | 61 | |
| GSE54994 | SREK1 | 140890 | 1 | 19 | 33 | |
| GSE60625 | SREK1 | 140890 | 0 | 0 | 11 | |
| GSE74703 | SREK1 | 140890 | 1 | 9 | 26 | |
| GSE74704 | SREK1 | 140890 | 0 | 6 | 14 | |
| TCGA | SREK1 | 140890 | 3 | 51 | 42 |
Total number of gains: 16; Total number of losses: 169; Total Number of normals: 303.
Somatic mutations of SREK1:
Generating mutation plots.
Highly correlated genes for SREK1:
Showing top 20/340 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SREK1 | EXOC1 | 0.779625 | 3 | 0 | 3 |
| SREK1 | SLC22A15 | 0.72247 | 3 | 0 | 3 |
| SREK1 | DPYD | 0.719143 | 3 | 0 | 3 |
| SREK1 | PRPF39 | 0.708356 | 6 | 0 | 6 |
| SREK1 | SUCLG1 | 0.705859 | 3 | 0 | 3 |
| SREK1 | SNRNP200 | 0.697654 | 4 | 0 | 4 |
| SREK1 | PPP1R7 | 0.688663 | 3 | 0 | 3 |
| SREK1 | TRIP4 | 0.68482 | 4 | 0 | 4 |
| SREK1 | RNF6 | 0.680863 | 5 | 0 | 4 |
| SREK1 | CHMP2A | 0.680699 | 3 | 0 | 3 |
| SREK1 | ZNF165 | 0.675516 | 3 | 0 | 3 |
| SREK1 | TRERF1 | 0.671383 | 3 | 0 | 3 |
| SREK1 | CUL3 | 0.665939 | 3 | 0 | 3 |
| SREK1 | PITPNA | 0.664771 | 4 | 0 | 4 |
| SREK1 | RIOK3 | 0.664393 | 3 | 0 | 3 |
| SREK1 | SLC38A9 | 0.664313 | 4 | 0 | 4 |
| SREK1 | RNF11 | 0.663515 | 4 | 0 | 4 |
| SREK1 | C12orf29 | 0.661482 | 3 | 0 | 3 |
| SREK1 | EAF1 | 0.66037 | 5 | 0 | 5 |
| SREK1 | CCDC115 | 0.658725 | 4 | 0 | 3 |
For details and further investigation, click here
