| Full name: sodium channel epithelial 1 beta subunit | Alias Symbol: ENaCbeta | ||
| Type: protein-coding gene | Cytoband: 16p12.2-p12.1 | ||
| Entrez ID: 6338 | HGNC ID: HGNC:10600 | Ensembl Gene: ENSG00000168447 | OMIM ID: 600760 |
| Drug and gene relationship at DGIdb | |||
SCNN1B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04960 | Aldosterone-regulated sodium reabsorption |
Expression of SCNN1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCNN1B | 6338 | 205464_at | -2.6826 | 0.0136 | |
| GSE20347 | SCNN1B | 6338 | 205464_at | -2.9505 | 0.0000 | |
| GSE23400 | SCNN1B | 6338 | 205464_at | -2.0354 | 0.0000 | |
| GSE26886 | SCNN1B | 6338 | 205464_at | -2.7759 | 0.0000 | |
| GSE29001 | SCNN1B | 6338 | 205464_at | -2.5307 | 0.0000 | |
| GSE38129 | SCNN1B | 6338 | 205464_at | -2.3354 | 0.0000 | |
| GSE45670 | SCNN1B | 6338 | 205464_at | -1.0246 | 0.0197 | |
| GSE53622 | SCNN1B | 6338 | 1963 | -3.4574 | 0.0000 | |
| GSE53624 | SCNN1B | 6338 | 1963 | -3.8389 | 0.0000 | |
| GSE63941 | SCNN1B | 6338 | 205464_at | 0.3498 | 0.5642 | |
| GSE77861 | SCNN1B | 6338 | 205464_at | -2.1122 | 0.0013 | |
| GSE97050 | SCNN1B | 6338 | A_32_P83098 | -0.3919 | 0.1703 | |
| SRP007169 | SCNN1B | 6338 | RNAseq | -7.3284 | 0.0000 | |
| SRP008496 | SCNN1B | 6338 | RNAseq | -6.1774 | 0.0000 | |
| SRP064894 | SCNN1B | 6338 | RNAseq | -3.9378 | 0.0000 | |
| SRP133303 | SCNN1B | 6338 | RNAseq | -3.9167 | 0.0000 | |
| SRP159526 | SCNN1B | 6338 | RNAseq | -4.1804 | 0.0000 | |
| SRP193095 | SCNN1B | 6338 | RNAseq | -3.7930 | 0.0000 | |
| SRP219564 | SCNN1B | 6338 | RNAseq | -3.2956 | 0.0007 | |
| TCGA | SCNN1B | 6338 | RNAseq | -0.9184 | 0.0050 |
Upregulated datasets: 0; Downregulated datasets: 17.
Survival by SCNN1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCNN1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCNN1B | 6338 | 6 | 4 | 20 | |
| GSE20123 | SCNN1B | 6338 | 6 | 3 | 21 | |
| GSE43470 | SCNN1B | 6338 | 3 | 3 | 37 | |
| GSE46452 | SCNN1B | 6338 | 38 | 1 | 20 | |
| GSE47630 | SCNN1B | 6338 | 11 | 6 | 23 | |
| GSE54993 | SCNN1B | 6338 | 3 | 5 | 62 | |
| GSE54994 | SCNN1B | 6338 | 4 | 9 | 40 | |
| GSE60625 | SCNN1B | 6338 | 4 | 0 | 7 | |
| GSE74703 | SCNN1B | 6338 | 3 | 2 | 31 | |
| GSE74704 | SCNN1B | 6338 | 3 | 1 | 16 | |
| TCGA | SCNN1B | 6338 | 19 | 13 | 64 |
Total number of gains: 100; Total number of losses: 47; Total Number of normals: 341.
Somatic mutations of SCNN1B:
Generating mutation plots.
Highly correlated genes for SCNN1B:
Showing top 20/1709 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCNN1B | GDPD3 | 0.920182 | 11 | 0 | 11 |
| SCNN1B | RMND5B | 0.916541 | 10 | 0 | 10 |
| SCNN1B | VSIG10L | 0.913174 | 7 | 0 | 7 |
| SCNN1B | SMIM5 | 0.907622 | 6 | 0 | 6 |
| SCNN1B | CYSRT1 | 0.897305 | 6 | 0 | 6 |
| SCNN1B | EHD3 | 0.896659 | 10 | 0 | 10 |
| SCNN1B | EPS8L2 | 0.89449 | 11 | 0 | 11 |
| SCNN1B | GYS2 | 0.890707 | 10 | 0 | 10 |
| SCNN1B | CXCR2 | 0.885751 | 10 | 0 | 10 |
| SCNN1B | BLNK | 0.884227 | 10 | 0 | 10 |
| SCNN1B | RANBP9 | 0.881995 | 10 | 0 | 10 |
| SCNN1B | SLC16A6 | 0.881369 | 10 | 0 | 10 |
| SCNN1B | UPK1A | 0.878473 | 11 | 0 | 11 |
| SCNN1B | PSCA | 0.878347 | 9 | 0 | 9 |
| SCNN1B | C5orf66-AS1 | 0.87833 | 6 | 0 | 6 |
| SCNN1B | ANXA9 | 0.873539 | 10 | 0 | 10 |
| SCNN1B | CRISP3 | 0.873428 | 11 | 0 | 11 |
| SCNN1B | KALRN | 0.87292 | 6 | 0 | 6 |
| SCNN1B | EPS8L1 | 0.872588 | 12 | 0 | 11 |
| SCNN1B | IL36A | 0.872326 | 11 | 0 | 11 |
For details and further investigation, click here
