| Full name: receptor interacting serine/threonine kinase 1 | Alias Symbol: RIP | ||
| Type: protein-coding gene | Cytoband: 6p25.2 | ||
| Entrez ID: 8737 | HGNC ID: HGNC:10019 | Ensembl Gene: ENSG00000137275 | OMIM ID: 603453 |
| Drug and gene relationship at DGIdb | |||
RIPK1 involved pathways:
Expression of RIPK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RIPK1 | 8737 | 226551_at | 0.0803 | 0.8572 | |
| GSE20347 | RIPK1 | 8737 | 209941_at | -0.4676 | 0.0001 | |
| GSE23400 | RIPK1 | 8737 | 209941_at | -0.0970 | 0.1002 | |
| GSE26886 | RIPK1 | 8737 | 226551_at | -0.7967 | 0.0000 | |
| GSE29001 | RIPK1 | 8737 | 209941_at | -0.5737 | 0.0113 | |
| GSE38129 | RIPK1 | 8737 | 209941_at | -0.4684 | 0.0002 | |
| GSE45670 | RIPK1 | 8737 | 226551_at | 0.1146 | 0.4739 | |
| GSE53622 | RIPK1 | 8737 | 90032 | -0.2974 | 0.0000 | |
| GSE53624 | RIPK1 | 8737 | 90032 | -0.1932 | 0.0000 | |
| GSE63941 | RIPK1 | 8737 | 226551_at | -0.5730 | 0.0477 | |
| GSE77861 | RIPK1 | 8737 | 226551_at | -0.0417 | 0.8373 | |
| GSE97050 | RIPK1 | 8737 | A_33_P3279059 | -0.1549 | 0.4373 | |
| SRP007169 | RIPK1 | 8737 | RNAseq | -0.1121 | 0.7651 | |
| SRP008496 | RIPK1 | 8737 | RNAseq | -0.0256 | 0.9058 | |
| SRP064894 | RIPK1 | 8737 | RNAseq | 0.0983 | 0.5810 | |
| SRP133303 | RIPK1 | 8737 | RNAseq | -0.2067 | 0.1450 | |
| SRP159526 | RIPK1 | 8737 | RNAseq | -0.3787 | 0.1319 | |
| SRP193095 | RIPK1 | 8737 | RNAseq | -0.3718 | 0.0001 | |
| SRP219564 | RIPK1 | 8737 | RNAseq | -0.2718 | 0.3268 | |
| TCGA | RIPK1 | 8737 | RNAseq | -0.1695 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RIPK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RIPK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RIPK1 | 8737 | 4 | 5 | 21 | |
| GSE20123 | RIPK1 | 8737 | 4 | 5 | 21 | |
| GSE43470 | RIPK1 | 8737 | 8 | 4 | 31 | |
| GSE46452 | RIPK1 | 8737 | 1 | 10 | 48 | |
| GSE47630 | RIPK1 | 8737 | 7 | 8 | 25 | |
| GSE54993 | RIPK1 | 8737 | 1 | 1 | 68 | |
| GSE54994 | RIPK1 | 8737 | 10 | 3 | 40 | |
| GSE60625 | RIPK1 | 8737 | 0 | 1 | 10 | |
| GSE74703 | RIPK1 | 8737 | 7 | 3 | 26 | |
| GSE74704 | RIPK1 | 8737 | 2 | 2 | 16 | |
| TCGA | RIPK1 | 8737 | 17 | 30 | 49 |
Total number of gains: 61; Total number of losses: 72; Total Number of normals: 355.
Somatic mutations of RIPK1:
Generating mutation plots.
Highly correlated genes for RIPK1:
Showing top 20/355 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RIPK1 | STAU2 | 0.693803 | 3 | 0 | 3 |
| RIPK1 | CYP2J2 | 0.661267 | 5 | 0 | 4 |
| RIPK1 | HMGN1 | 0.654039 | 4 | 0 | 3 |
| RIPK1 | CXCR2 | 0.652656 | 5 | 0 | 5 |
| RIPK1 | MED23 | 0.650695 | 3 | 0 | 3 |
| RIPK1 | WDR83OS | 0.649528 | 3 | 0 | 3 |
| RIPK1 | ZNF675 | 0.649342 | 3 | 0 | 3 |
| RIPK1 | CSTA | 0.648554 | 3 | 0 | 3 |
| RIPK1 | AZI2 | 0.633649 | 5 | 0 | 4 |
| RIPK1 | GCC1 | 0.629657 | 4 | 0 | 3 |
| RIPK1 | WDR37 | 0.626519 | 3 | 0 | 3 |
| RIPK1 | NGLY1 | 0.624991 | 6 | 0 | 5 |
| RIPK1 | ZNF564 | 0.624976 | 4 | 0 | 3 |
| RIPK1 | CTTNBP2NL | 0.623476 | 3 | 0 | 3 |
| RIPK1 | C6orf62 | 0.618077 | 6 | 0 | 5 |
| RIPK1 | LACC1 | 0.616773 | 4 | 0 | 4 |
| RIPK1 | SUCLG2 | 0.612182 | 6 | 0 | 6 |
| RIPK1 | LCMT1 | 0.611885 | 3 | 0 | 3 |
| RIPK1 | ITPRIPL2 | 0.610852 | 4 | 0 | 3 |
| RIPK1 | FAM149B1 | 0.608547 | 7 | 0 | 5 |
For details and further investigation, click here
