| Full name: mediator complex subunit 23 | Alias Symbol: CRSP130|DRIP130|Sur2 | ||
| Type: protein-coding gene | Cytoband: 6q23.2 | ||
| Entrez ID: 9439 | HGNC ID: HGNC:2372 | Ensembl Gene: ENSG00000112282 | OMIM ID: 605042 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MED23:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MED23 | 9439 | 218846_at | 0.4208 | 0.4319 | |
| GSE20347 | MED23 | 9439 | 218846_at | -0.1987 | 0.0787 | |
| GSE23400 | MED23 | 9439 | 218846_at | 0.0367 | 0.6161 | |
| GSE26886 | MED23 | 9439 | 218846_at | 0.3170 | 0.2391 | |
| GSE29001 | MED23 | 9439 | 218846_at | -0.2461 | 0.3709 | |
| GSE38129 | MED23 | 9439 | 218846_at | -0.0767 | 0.4976 | |
| GSE45670 | MED23 | 9439 | 218846_at | -0.0051 | 0.9745 | |
| GSE53622 | MED23 | 9439 | 55615 | 0.0330 | 0.5752 | |
| GSE53624 | MED23 | 9439 | 85718 | 0.0055 | 0.9417 | |
| GSE63941 | MED23 | 9439 | 218846_at | -1.2356 | 0.0134 | |
| GSE77861 | MED23 | 9439 | 218846_at | -0.4146 | 0.1953 | |
| GSE97050 | MED23 | 9439 | A_23_P145501 | -0.1086 | 0.6110 | |
| SRP007169 | MED23 | 9439 | RNAseq | 0.0973 | 0.7701 | |
| SRP008496 | MED23 | 9439 | RNAseq | -0.0963 | 0.5714 | |
| SRP064894 | MED23 | 9439 | RNAseq | -0.1497 | 0.5494 | |
| SRP133303 | MED23 | 9439 | RNAseq | -0.1039 | 0.3233 | |
| SRP159526 | MED23 | 9439 | RNAseq | -0.1696 | 0.4140 | |
| SRP193095 | MED23 | 9439 | RNAseq | -0.3538 | 0.0000 | |
| SRP219564 | MED23 | 9439 | RNAseq | -0.1903 | 0.6059 | |
| TCGA | MED23 | 9439 | RNAseq | -0.1093 | 0.0227 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MED23 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MED23:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MED23 | 9439 | 2 | 5 | 23 | |
| GSE20123 | MED23 | 9439 | 2 | 4 | 24 | |
| GSE43470 | MED23 | 9439 | 5 | 0 | 38 | |
| GSE46452 | MED23 | 9439 | 2 | 11 | 46 | |
| GSE47630 | MED23 | 9439 | 9 | 4 | 27 | |
| GSE54993 | MED23 | 9439 | 3 | 2 | 65 | |
| GSE54994 | MED23 | 9439 | 9 | 7 | 37 | |
| GSE60625 | MED23 | 9439 | 0 | 1 | 10 | |
| GSE74703 | MED23 | 9439 | 4 | 0 | 32 | |
| GSE74704 | MED23 | 9439 | 1 | 1 | 18 | |
| TCGA | MED23 | 9439 | 11 | 19 | 66 |
Total number of gains: 48; Total number of losses: 54; Total Number of normals: 386.
Somatic mutations of MED23:
Generating mutation plots.
Highly correlated genes for MED23:
Showing top 20/364 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MED23 | ZNF260 | 0.82089 | 3 | 0 | 3 |
| MED23 | ZNF567 | 0.793516 | 3 | 0 | 3 |
| MED23 | EI24 | 0.792567 | 3 | 0 | 3 |
| MED23 | CDK10 | 0.780296 | 3 | 0 | 3 |
| MED23 | HYLS1 | 0.774415 | 3 | 0 | 3 |
| MED23 | SLC35A2 | 0.767775 | 3 | 0 | 3 |
| MED23 | ZNF578 | 0.754409 | 3 | 0 | 3 |
| MED23 | C12orf73 | 0.746037 | 3 | 0 | 3 |
| MED23 | HCFC2 | 0.741314 | 3 | 0 | 3 |
| MED23 | C2orf76 | 0.740888 | 3 | 0 | 3 |
| MED23 | STK38 | 0.732741 | 4 | 0 | 3 |
| MED23 | ZNF394 | 0.725551 | 3 | 0 | 3 |
| MED23 | ZNF223 | 0.724077 | 3 | 0 | 3 |
| MED23 | EPG5 | 0.723487 | 3 | 0 | 3 |
| MED23 | TRIM56 | 0.711125 | 4 | 0 | 3 |
| MED23 | ARID1B | 0.708052 | 6 | 0 | 5 |
| MED23 | ZMPSTE24 | 0.70218 | 4 | 0 | 4 |
| MED23 | ZNF529 | 0.700425 | 3 | 0 | 3 |
| MED23 | GOLPH3 | 0.697743 | 3 | 0 | 3 |
| MED23 | ESCO1 | 0.696703 | 3 | 0 | 3 |
For details and further investigation, click here
