| Full name: 5-azacytidine induced 2 | Alias Symbol: NAP1|FLJ21939|AZ2 | ||
| Type: protein-coding gene | Cytoband: 3p24.1 | ||
| Entrez ID: 64343 | HGNC ID: HGNC:24002 | Ensembl Gene: ENSG00000163512 | OMIM ID: 609916 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
AZI2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04622 | RIG-I-like receptor signaling pathway |
Expression of AZI2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AZI2 | 64343 | 222498_at | -0.6816 | 0.0216 | |
| GSE20347 | AZI2 | 64343 | 218043_s_at | -0.8301 | 0.0000 | |
| GSE23400 | AZI2 | 64343 | 218043_s_at | -0.1198 | 0.0015 | |
| GSE26886 | AZI2 | 64343 | 222498_at | -1.7059 | 0.0000 | |
| GSE29001 | AZI2 | 64343 | 218043_s_at | -0.5970 | 0.0551 | |
| GSE38129 | AZI2 | 64343 | 218043_s_at | -0.8598 | 0.0000 | |
| GSE45670 | AZI2 | 64343 | 222498_at | -0.6315 | 0.0000 | |
| GSE53622 | AZI2 | 64343 | 64341 | -0.4333 | 0.0000 | |
| GSE53624 | AZI2 | 64343 | 64341 | -0.3645 | 0.0000 | |
| GSE63941 | AZI2 | 64343 | 227904_at | -1.0099 | 0.0472 | |
| GSE77861 | AZI2 | 64343 | 218043_s_at | -0.5751 | 0.0026 | |
| GSE97050 | AZI2 | 64343 | A_33_P3322288 | -0.1624 | 0.4352 | |
| SRP007169 | AZI2 | 64343 | RNAseq | -1.1247 | 0.0009 | |
| SRP008496 | AZI2 | 64343 | RNAseq | -0.9932 | 0.0000 | |
| SRP064894 | AZI2 | 64343 | RNAseq | -0.2458 | 0.3080 | |
| SRP133303 | AZI2 | 64343 | RNAseq | -0.2349 | 0.1385 | |
| SRP159526 | AZI2 | 64343 | RNAseq | -0.4220 | 0.0039 | |
| SRP193095 | AZI2 | 64343 | RNAseq | -0.6954 | 0.0000 | |
| SRP219564 | AZI2 | 64343 | RNAseq | -0.4271 | 0.0890 | |
| TCGA | AZI2 | 64343 | RNAseq | -0.2394 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by AZI2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AZI2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AZI2 | 64343 | 0 | 18 | 12 | |
| GSE20123 | AZI2 | 64343 | 0 | 18 | 12 | |
| GSE43470 | AZI2 | 64343 | 0 | 20 | 23 | |
| GSE46452 | AZI2 | 64343 | 2 | 17 | 40 | |
| GSE47630 | AZI2 | 64343 | 1 | 24 | 15 | |
| GSE54993 | AZI2 | 64343 | 6 | 2 | 62 | |
| GSE54994 | AZI2 | 64343 | 2 | 31 | 20 | |
| GSE60625 | AZI2 | 64343 | 5 | 0 | 6 | |
| GSE74703 | AZI2 | 64343 | 0 | 17 | 19 | |
| GSE74704 | AZI2 | 64343 | 0 | 12 | 8 | |
| TCGA | AZI2 | 64343 | 2 | 69 | 25 |
Total number of gains: 18; Total number of losses: 228; Total Number of normals: 242.
Somatic mutations of AZI2:
Generating mutation plots.
Highly correlated genes for AZI2:
Showing top 20/1549 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AZI2 | SPAG17 | 0.775712 | 3 | 0 | 3 |
| AZI2 | N4BP1 | 0.771672 | 3 | 0 | 3 |
| AZI2 | KLF5 | 0.770185 | 3 | 0 | 3 |
| AZI2 | ZNF248 | 0.769228 | 3 | 0 | 3 |
| AZI2 | UBQLN1 | 0.761223 | 3 | 0 | 3 |
| AZI2 | MTMR3 | 0.743176 | 5 | 0 | 5 |
| AZI2 | TMCO4 | 0.739394 | 3 | 0 | 3 |
| AZI2 | CRBN | 0.738123 | 8 | 0 | 8 |
| AZI2 | APOB | 0.737827 | 4 | 0 | 3 |
| AZI2 | EIF4E3 | 0.73188 | 8 | 0 | 7 |
| AZI2 | PPP1R2 | 0.73006 | 4 | 0 | 3 |
| AZI2 | GOLGA4 | 0.726682 | 9 | 0 | 9 |
| AZI2 | DPY19L3 | 0.725964 | 3 | 0 | 3 |
| AZI2 | RHOJ | 0.724657 | 3 | 0 | 3 |
| AZI2 | AK3 | 0.7207 | 7 | 0 | 7 |
| AZI2 | ANGPTL1 | 0.717928 | 5 | 0 | 5 |
| AZI2 | RBBP6 | 0.716581 | 3 | 0 | 3 |
| AZI2 | GAB1 | 0.710524 | 9 | 0 | 7 |
| AZI2 | EIF4ENIF1 | 0.710429 | 4 | 0 | 4 |
| AZI2 | RBM20 | 0.710258 | 5 | 0 | 4 |
For details and further investigation, click here
