| Full name: N-glycanase 1 | Alias Symbol: FLJ11005|PNG1 | ||
| Type: protein-coding gene | Cytoband: 3p24.2 | ||
| Entrez ID: 55768 | HGNC ID: HGNC:17646 | Ensembl Gene: ENSG00000151092 | OMIM ID: 610661 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NGLY1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NGLY1 | 55768 | 220742_s_at | -0.3578 | 0.2147 | |
| GSE20347 | NGLY1 | 55768 | 220742_s_at | -0.4813 | 0.0003 | |
| GSE23400 | NGLY1 | 55768 | 220742_s_at | -0.2119 | 0.0005 | |
| GSE26886 | NGLY1 | 55768 | 220742_s_at | -1.3971 | 0.0000 | |
| GSE29001 | NGLY1 | 55768 | 220742_s_at | -0.4831 | 0.0629 | |
| GSE38129 | NGLY1 | 55768 | 220742_s_at | -0.4043 | 0.0002 | |
| GSE45670 | NGLY1 | 55768 | 220742_s_at | -0.3736 | 0.0030 | |
| GSE53622 | NGLY1 | 55768 | 13833 | -0.5186 | 0.0000 | |
| GSE53624 | NGLY1 | 55768 | 13833 | -0.5984 | 0.0000 | |
| GSE63941 | NGLY1 | 55768 | 220742_s_at | -0.1536 | 0.7672 | |
| GSE77861 | NGLY1 | 55768 | 220742_s_at | -0.5239 | 0.0029 | |
| GSE97050 | NGLY1 | 55768 | A_23_P218841 | -0.0235 | 0.9435 | |
| SRP007169 | NGLY1 | 55768 | RNAseq | -0.8488 | 0.0129 | |
| SRP008496 | NGLY1 | 55768 | RNAseq | -0.7550 | 0.0005 | |
| SRP064894 | NGLY1 | 55768 | RNAseq | -0.4858 | 0.0000 | |
| SRP133303 | NGLY1 | 55768 | RNAseq | -0.5204 | 0.0026 | |
| SRP159526 | NGLY1 | 55768 | RNAseq | -0.7105 | 0.0013 | |
| SRP193095 | NGLY1 | 55768 | RNAseq | -0.6912 | 0.0000 | |
| SRP219564 | NGLY1 | 55768 | RNAseq | -0.5163 | 0.1350 | |
| TCGA | NGLY1 | 55768 | RNAseq | -0.2619 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by NGLY1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NGLY1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NGLY1 | 55768 | 0 | 18 | 12 | |
| GSE20123 | NGLY1 | 55768 | 0 | 18 | 12 | |
| GSE43470 | NGLY1 | 55768 | 0 | 20 | 23 | |
| GSE46452 | NGLY1 | 55768 | 2 | 17 | 40 | |
| GSE47630 | NGLY1 | 55768 | 1 | 24 | 15 | |
| GSE54993 | NGLY1 | 55768 | 6 | 2 | 62 | |
| GSE54994 | NGLY1 | 55768 | 1 | 32 | 20 | |
| GSE60625 | NGLY1 | 55768 | 5 | 0 | 6 | |
| GSE74703 | NGLY1 | 55768 | 0 | 17 | 19 | |
| GSE74704 | NGLY1 | 55768 | 0 | 12 | 8 | |
| TCGA | NGLY1 | 55768 | 1 | 68 | 27 |
Total number of gains: 16; Total number of losses: 228; Total Number of normals: 244.
Somatic mutations of NGLY1:
Generating mutation plots.
Highly correlated genes for NGLY1:
Showing top 20/1523 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NGLY1 | SH3PXD2A-AS1 | 0.773165 | 3 | 0 | 3 |
| NGLY1 | FAM83D | 0.752183 | 3 | 0 | 3 |
| NGLY1 | SPAG17 | 0.748276 | 3 | 0 | 3 |
| NGLY1 | PLEKHA7 | 0.733241 | 7 | 0 | 6 |
| NGLY1 | FAM174A | 0.714067 | 6 | 0 | 6 |
| NGLY1 | TMEM19 | 0.713838 | 5 | 0 | 5 |
| NGLY1 | ORMDL2 | 0.713439 | 6 | 0 | 5 |
| NGLY1 | ZDHHC21 | 0.710958 | 5 | 0 | 5 |
| NGLY1 | SUCLG2 | 0.710115 | 12 | 0 | 11 |
| NGLY1 | PITHD1 | 0.709715 | 5 | 0 | 5 |
| NGLY1 | LAPTM4A | 0.709069 | 3 | 0 | 3 |
| NGLY1 | ANKRD37 | 0.705764 | 4 | 0 | 4 |
| NGLY1 | SLC46A2 | 0.702489 | 6 | 0 | 6 |
| NGLY1 | TIFA | 0.697106 | 7 | 0 | 7 |
| NGLY1 | PET100 | 0.696676 | 3 | 0 | 3 |
| NGLY1 | TRNP1 | 0.696475 | 5 | 0 | 5 |
| NGLY1 | CCDC7 | 0.695859 | 3 | 0 | 3 |
| NGLY1 | LINC00551 | 0.692999 | 3 | 0 | 3 |
| NGLY1 | SPINK7 | 0.692153 | 5 | 0 | 5 |
| NGLY1 | VSIG10L | 0.692128 | 5 | 0 | 4 |
For details and further investigation, click here
