| Full name: RAR related orphan receptor A | Alias Symbol: RZRA|ROR1|ROR2|ROR3|NR1F1 | ||
| Type: protein-coding gene | Cytoband: 15q22.2 | ||
| Entrez ID: 6095 | HGNC ID: HGNC:10258 | Ensembl Gene: ENSG00000069667 | OMIM ID: 600825 |
| Drug and gene relationship at DGIdb | |||
RORA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04710 | Circadian rhythm | |
| hsa05321 | Inflammatory bowel disease (IBD) |
Expression of RORA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RORA | 6095 | 226682_at | -1.2969 | 0.0581 | |
| GSE20347 | RORA | 6095 | 210426_x_at | -2.0100 | 0.0000 | |
| GSE23400 | RORA | 6095 | 210426_x_at | -1.3406 | 0.0000 | |
| GSE26886 | RORA | 6095 | 226682_at | -1.3927 | 0.0011 | |
| GSE29001 | RORA | 6095 | 210479_s_at | -1.8087 | 0.0183 | |
| GSE38129 | RORA | 6095 | 210426_x_at | -1.7047 | 0.0000 | |
| GSE45670 | RORA | 6095 | 226682_at | -1.6131 | 0.0000 | |
| GSE53622 | RORA | 6095 | 11398 | -1.4274 | 0.0000 | |
| GSE53624 | RORA | 6095 | 11398 | -1.8018 | 0.0000 | |
| GSE63941 | RORA | 6095 | 226682_at | -3.2105 | 0.0105 | |
| GSE77861 | RORA | 6095 | 226682_at | -0.7538 | 0.1883 | |
| GSE97050 | RORA | 6095 | A_23_P26124 | -0.8737 | 0.0555 | |
| SRP007169 | RORA | 6095 | RNAseq | -2.2618 | 0.0000 | |
| SRP008496 | RORA | 6095 | RNAseq | -1.7665 | 0.0000 | |
| SRP064894 | RORA | 6095 | RNAseq | -1.7263 | 0.0000 | |
| SRP133303 | RORA | 6095 | RNAseq | -1.0521 | 0.0000 | |
| SRP159526 | RORA | 6095 | RNAseq | -1.5452 | 0.0004 | |
| SRP193095 | RORA | 6095 | RNAseq | -1.1462 | 0.0000 | |
| SRP219564 | RORA | 6095 | RNAseq | -1.5944 | 0.0042 | |
| TCGA | RORA | 6095 | RNAseq | -0.1672 | 0.1565 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by RORA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RORA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RORA | 6095 | 7 | 3 | 20 | |
| GSE20123 | RORA | 6095 | 7 | 2 | 21 | |
| GSE43470 | RORA | 6095 | 4 | 6 | 33 | |
| GSE46452 | RORA | 6095 | 3 | 7 | 49 | |
| GSE47630 | RORA | 6095 | 8 | 10 | 22 | |
| GSE54993 | RORA | 6095 | 5 | 6 | 59 | |
| GSE54994 | RORA | 6095 | 6 | 8 | 39 | |
| GSE60625 | RORA | 6095 | 4 | 0 | 7 | |
| GSE74703 | RORA | 6095 | 4 | 3 | 29 | |
| GSE74704 | RORA | 6095 | 3 | 3 | 14 | |
| TCGA | RORA | 6095 | 10 | 22 | 64 |
Total number of gains: 61; Total number of losses: 70; Total Number of normals: 357.
Somatic mutations of RORA:
Generating mutation plots.
Highly correlated genes for RORA:
Showing top 20/1711 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RORA | MTMR10 | 0.781397 | 8 | 0 | 8 |
| RORA | UBQLN1 | 0.771696 | 3 | 0 | 3 |
| RORA | ACRBP | 0.768722 | 3 | 0 | 3 |
| RORA | CA13 | 0.766829 | 3 | 0 | 3 |
| RORA | KAT2B | 0.764402 | 12 | 0 | 12 |
| RORA | SENP8 | 0.763512 | 3 | 0 | 3 |
| RORA | CASC3 | 0.759421 | 3 | 0 | 3 |
| RORA | WDR26 | 0.756872 | 11 | 0 | 11 |
| RORA | SH3BGRL2 | 0.755016 | 7 | 0 | 7 |
| RORA | TMEM167B | 0.754731 | 5 | 0 | 5 |
| RORA | CTTNBP2 | 0.753136 | 7 | 0 | 7 |
| RORA | FAM219B | 0.751871 | 4 | 0 | 4 |
| RORA | SORT1 | 0.750288 | 12 | 0 | 11 |
| RORA | ZNF564 | 0.750232 | 3 | 0 | 3 |
| RORA | FAM214A | 0.749985 | 7 | 0 | 6 |
| RORA | SCARB2 | 0.749005 | 3 | 0 | 3 |
| RORA | UBL3 | 0.746416 | 10 | 0 | 10 |
| RORA | ZNF175 | 0.746278 | 3 | 0 | 3 |
| RORA | CNKSR3 | 0.742587 | 6 | 0 | 6 |
| RORA | ZMYND11 | 0.738392 | 3 | 0 | 3 |
For details and further investigation, click here
