| Full name: RAR related orphan receptor C | Alias Symbol: RZRG|RORG|NR1F3|TOR | ||
| Type: protein-coding gene | Cytoband: 1q21 | ||
| Entrez ID: 6097 | HGNC ID: HGNC:10260 | Ensembl Gene: ENSG00000143365 | OMIM ID: 602943 |
| Drug and gene relationship at DGIdb | |||
RORC involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04710 | Circadian rhythm | |
| hsa05321 | Inflammatory bowel disease (IBD) |
Expression of RORC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RORC | 6097 | 206419_at | -0.2959 | 0.1500 | |
| GSE20347 | RORC | 6097 | 206419_at | -0.0892 | 0.3311 | |
| GSE23400 | RORC | 6097 | 206419_at | -0.2023 | 0.0000 | |
| GSE26886 | RORC | 6097 | 206419_at | -0.2729 | 0.0344 | |
| GSE29001 | RORC | 6097 | 206419_at | -0.2664 | 0.1476 | |
| GSE38129 | RORC | 6097 | 206419_at | -0.2203 | 0.0175 | |
| GSE45670 | RORC | 6097 | 206419_at | -0.0297 | 0.7687 | |
| GSE63941 | RORC | 6097 | 206419_at | 0.3923 | 0.0355 | |
| GSE77861 | RORC | 6097 | 206419_at | -0.0972 | 0.3823 | |
| GSE97050 | RORC | 6097 | A_33_P3386671 | -0.3499 | 0.2779 | |
| SRP007169 | RORC | 6097 | RNAseq | -6.7942 | 0.0000 | |
| SRP008496 | RORC | 6097 | RNAseq | -6.3298 | 0.0000 | |
| SRP064894 | RORC | 6097 | RNAseq | -3.4955 | 0.0000 | |
| SRP133303 | RORC | 6097 | RNAseq | -3.1323 | 0.0000 | |
| SRP159526 | RORC | 6097 | RNAseq | -4.1540 | 0.0000 | |
| SRP193095 | RORC | 6097 | RNAseq | -1.9870 | 0.0000 | |
| TCGA | RORC | 6097 | RNAseq | -1.9625 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by RORC expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of RORC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RORC | 6097 | 15 | 0 | 15 | |
| GSE20123 | RORC | 6097 | 15 | 0 | 15 | |
| GSE43470 | RORC | 6097 | 8 | 2 | 33 | |
| GSE46452 | RORC | 6097 | 2 | 1 | 56 | |
| GSE47630 | RORC | 6097 | 15 | 0 | 25 | |
| GSE54993 | RORC | 6097 | 0 | 4 | 66 | |
| GSE54994 | RORC | 6097 | 15 | 0 | 38 | |
| GSE60625 | RORC | 6097 | 0 | 0 | 11 | |
| GSE74703 | RORC | 6097 | 7 | 1 | 28 | |
| GSE74704 | RORC | 6097 | 7 | 0 | 13 | |
| TCGA | RORC | 6097 | 39 | 2 | 55 |
Total number of gains: 123; Total number of losses: 10; Total Number of normals: 355.
Somatic mutations of RORC:
Generating mutation plots.
Highly correlated genes for RORC:
Showing top 20/1117 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RORC | LINGO3 | 0.723821 | 3 | 0 | 3 |
| RORC | CNR2 | 0.704202 | 9 | 0 | 9 |
| RORC | CBLN1 | 0.700595 | 5 | 0 | 5 |
| RORC | IL25 | 0.697067 | 6 | 0 | 6 |
| RORC | CYP4F2 | 0.69317 | 3 | 0 | 3 |
| RORC | EPO | 0.691762 | 4 | 0 | 4 |
| RORC | HHLA1 | 0.691735 | 6 | 0 | 5 |
| RORC | CYP2A6 | 0.691082 | 6 | 0 | 6 |
| RORC | ART1 | 0.68659 | 6 | 0 | 5 |
| RORC | SLC6A5 | 0.684613 | 4 | 0 | 3 |
| RORC | PSG7 | 0.684063 | 6 | 0 | 5 |
| RORC | PHLDB1 | 0.68323 | 8 | 0 | 7 |
| RORC | P2RX6 | 0.681856 | 6 | 0 | 6 |
| RORC | FANCD2OS | 0.67989 | 3 | 0 | 3 |
| RORC | TAAR2 | 0.679056 | 6 | 0 | 5 |
| RORC | ARHGAP44 | 0.676937 | 6 | 0 | 6 |
| RORC | CYP2A7 | 0.67432 | 8 | 0 | 7 |
| RORC | PSG9 | 0.674016 | 5 | 0 | 4 |
| RORC | RPL36A | 0.673753 | 3 | 0 | 3 |
| RORC | TEX101 | 0.672181 | 3 | 0 | 3 |
For details and further investigation, click here
