| Full name: ribosomal protein S8 | Alias Symbol: S8 | ||
| Type: protein-coding gene | Cytoband: 1p34.1 | ||
| Entrez ID: 6202 | HGNC ID: HGNC:10441 | Ensembl Gene: ENSG00000142937 | OMIM ID: 600357 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of RPS8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPS8 | 6202 | 214089_at | -0.1823 | 0.3859 | |
| GSE20347 | RPS8 | 6202 | 214089_at | -0.1259 | 0.0403 | |
| GSE23400 | RPS8 | 6202 | 214089_at | -0.1128 | 0.0005 | |
| GSE26886 | RPS8 | 6202 | 214089_at | -0.0744 | 0.6499 | |
| GSE29001 | RPS8 | 6202 | 214089_at | -0.1797 | 0.0718 | |
| GSE38129 | RPS8 | 6202 | 214089_at | -0.0931 | 0.0999 | |
| GSE45670 | RPS8 | 6202 | 214089_at | 0.0542 | 0.5525 | |
| GSE53622 | RPS8 | 6202 | 94292 | -0.4156 | 0.0000 | |
| GSE53624 | RPS8 | 6202 | 94292 | -0.1152 | 0.0241 | |
| GSE63941 | RPS8 | 6202 | 214089_at | -0.1778 | 0.1809 | |
| GSE77861 | RPS8 | 6202 | 214089_at | -0.1540 | 0.1420 | |
| GSE97050 | RPS8 | 6202 | A_23_P46182 | -0.5233 | 0.2727 | |
| SRP007169 | RPS8 | 6202 | RNAseq | -1.5296 | 0.0000 | |
| SRP008496 | RPS8 | 6202 | RNAseq | -1.4707 | 0.0000 | |
| SRP064894 | RPS8 | 6202 | RNAseq | -0.5072 | 0.0984 | |
| SRP133303 | RPS8 | 6202 | RNAseq | -0.7047 | 0.0000 | |
| SRP159526 | RPS8 | 6202 | RNAseq | -0.9432 | 0.0000 | |
| SRP193095 | RPS8 | 6202 | RNAseq | -1.0848 | 0.0000 | |
| SRP219564 | RPS8 | 6202 | RNAseq | -0.3205 | 0.3947 | |
| TCGA | RPS8 | 6202 | RNAseq | 0.0265 | 0.5435 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by RPS8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPS8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPS8 | 6202 | 4 | 3 | 23 | |
| GSE20123 | RPS8 | 6202 | 4 | 2 | 24 | |
| GSE43470 | RPS8 | 6202 | 7 | 2 | 34 | |
| GSE46452 | RPS8 | 6202 | 2 | 1 | 56 | |
| GSE47630 | RPS8 | 6202 | 9 | 3 | 28 | |
| GSE54993 | RPS8 | 6202 | 0 | 1 | 69 | |
| GSE54994 | RPS8 | 6202 | 13 | 2 | 38 | |
| GSE60625 | RPS8 | 6202 | 0 | 0 | 11 | |
| GSE74703 | RPS8 | 6202 | 6 | 1 | 29 | |
| GSE74704 | RPS8 | 6202 | 2 | 0 | 18 | |
| TCGA | RPS8 | 6202 | 13 | 16 | 67 |
Total number of gains: 60; Total number of losses: 31; Total Number of normals: 397.
Somatic mutations of RPS8:
Generating mutation plots.
Highly correlated genes for RPS8:
Showing top 20/268 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPS8 | RPS13 | 0.769485 | 4 | 0 | 4 |
| RPS8 | ESRRB | 0.670282 | 4 | 0 | 4 |
| RPS8 | RPL15 | 0.661808 | 4 | 0 | 3 |
| RPS8 | NDUFA11 | 0.651745 | 3 | 0 | 3 |
| RPS8 | MRPL20 | 0.651012 | 3 | 0 | 3 |
| RPS8 | SLC46A2 | 0.642256 | 3 | 0 | 3 |
| RPS8 | NPAP1 | 0.635079 | 3 | 0 | 3 |
| RPS8 | RPL13A | 0.630992 | 4 | 0 | 4 |
| RPS8 | PLEKHA7 | 0.628413 | 3 | 0 | 3 |
| RPS8 | ASCL3 | 0.62575 | 3 | 0 | 3 |
| RPS8 | RPL18A | 0.624976 | 4 | 0 | 3 |
| RPS8 | GRPR | 0.624827 | 3 | 0 | 3 |
| RPS8 | GOLPH3L | 0.624814 | 3 | 0 | 3 |
| RPS8 | RPL24 | 0.621853 | 4 | 0 | 3 |
| RPS8 | ARMC4 | 0.621844 | 4 | 0 | 4 |
| RPS8 | TMEM59 | 0.62002 | 3 | 0 | 3 |
| RPS8 | GPR31 | 0.619484 | 3 | 0 | 3 |
| RPS8 | RPL23 | 0.619056 | 3 | 0 | 3 |
| RPS8 | RPS4X | 0.618261 | 4 | 0 | 3 |
| RPS8 | RPL19 | 0.615253 | 4 | 0 | 3 |
For details and further investigation, click here
