| Full name: estrogen related receptor beta | Alias Symbol: ERR2|ERRbeta|NR3B2|ERRb | ||
| Type: protein-coding gene | Cytoband: 14q24.3 | ||
| Entrez ID: 2103 | HGNC ID: HGNC:3473 | Ensembl Gene: ENSG00000119715 | OMIM ID: 602167 |
| Drug and gene relationship at DGIdb | |||
ESRRB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04550 | Signaling pathways regulating pluripotency of stem cells |
Expression of ESRRB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ESRRB | 2103 | 223858_at | -0.0330 | 0.9460 | |
| GSE20347 | ESRRB | 2103 | 207726_at | -0.0759 | 0.3163 | |
| GSE23400 | ESRRB | 2103 | 207726_at | -0.1442 | 0.0011 | |
| GSE26886 | ESRRB | 2103 | 223858_at | 0.0550 | 0.7068 | |
| GSE29001 | ESRRB | 2103 | 207726_at | -0.1982 | 0.1033 | |
| GSE38129 | ESRRB | 2103 | 207726_at | -0.1261 | 0.0418 | |
| GSE45670 | ESRRB | 2103 | 223858_at | 0.1102 | 0.1543 | |
| GSE53622 | ESRRB | 2103 | 99749 | 0.0320 | 0.8233 | |
| GSE53624 | ESRRB | 2103 | 99749 | 0.1015 | 0.3191 | |
| GSE63941 | ESRRB | 2103 | 223858_at | 0.0589 | 0.7181 | |
| GSE77861 | ESRRB | 2103 | 223858_at | -0.1167 | 0.3774 | |
| TCGA | ESRRB | 2103 | RNAseq | -3.8005 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ESRRB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ESRRB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ESRRB | 2103 | 8 | 3 | 19 | |
| GSE20123 | ESRRB | 2103 | 8 | 3 | 19 | |
| GSE43470 | ESRRB | 2103 | 8 | 3 | 32 | |
| GSE46452 | ESRRB | 2103 | 16 | 3 | 40 | |
| GSE47630 | ESRRB | 2103 | 11 | 8 | 21 | |
| GSE54993 | ESRRB | 2103 | 3 | 8 | 59 | |
| GSE54994 | ESRRB | 2103 | 19 | 4 | 30 | |
| GSE60625 | ESRRB | 2103 | 0 | 2 | 9 | |
| GSE74703 | ESRRB | 2103 | 7 | 3 | 26 | |
| GSE74704 | ESRRB | 2103 | 3 | 3 | 14 | |
| TCGA | ESRRB | 2103 | 32 | 16 | 48 |
Total number of gains: 115; Total number of losses: 56; Total Number of normals: 317.
Somatic mutations of ESRRB:
Generating mutation plots.
Highly correlated genes for ESRRB:
Showing top 20/582 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ESRRB | ADCY1 | 0.71499 | 3 | 0 | 3 |
| ESRRB | CHRNA3 | 0.701123 | 3 | 0 | 3 |
| ESRRB | WNT8B | 0.681843 | 3 | 0 | 3 |
| ESRRB | RPS8 | 0.670282 | 4 | 0 | 4 |
| ESRRB | CEACAM3 | 0.668137 | 4 | 0 | 4 |
| ESRRB | TAL1 | 0.659623 | 5 | 0 | 5 |
| ESRRB | RBP4 | 0.657898 | 3 | 0 | 3 |
| ESRRB | CALY | 0.657177 | 4 | 0 | 4 |
| ESRRB | C1orf167 | 0.65554 | 3 | 0 | 3 |
| ESRRB | PRPH2 | 0.651614 | 5 | 0 | 4 |
| ESRRB | LEFTY1 | 0.649686 | 4 | 0 | 3 |
| ESRRB | MYF6 | 0.648111 | 3 | 0 | 3 |
| ESRRB | CCR4 | 0.645713 | 4 | 0 | 4 |
| ESRRB | NR0B2 | 0.645092 | 5 | 0 | 4 |
| ESRRB | INCENP | 0.644997 | 3 | 0 | 3 |
| ESRRB | GNRH2 | 0.641968 | 4 | 0 | 3 |
| ESRRB | BTN1A1 | 0.641447 | 4 | 0 | 4 |
| ESRRB | OPRK1 | 0.640366 | 3 | 0 | 3 |
| ESRRB | LBX1 | 0.639635 | 3 | 0 | 3 |
| ESRRB | ARMC4 | 0.638743 | 5 | 0 | 4 |
For details and further investigation, click here
