| Full name: transmembrane protein 59 | Alias Symbol: HSPC001 | ||
| Type: protein-coding gene | Cytoband: 1p32.3 | ||
| Entrez ID: 9528 | HGNC ID: HGNC:1239 | Ensembl Gene: ENSG00000116209 | OMIM ID: 617084 |
| Drug and gene relationship at DGIdb | |||
Expression of TMEM59:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMEM59 | 9528 | 200620_at | -0.3406 | 0.3264 | |
| GSE20347 | TMEM59 | 9528 | 200620_at | -0.6552 | 0.0000 | |
| GSE23400 | TMEM59 | 9528 | 200620_at | -0.4552 | 0.0000 | |
| GSE26886 | TMEM59 | 9528 | 200620_at | -1.0938 | 0.0000 | |
| GSE29001 | TMEM59 | 9528 | 200620_at | -0.7156 | 0.0243 | |
| GSE38129 | TMEM59 | 9528 | 200620_at | -0.5413 | 0.0000 | |
| GSE45670 | TMEM59 | 9528 | 200620_at | -0.2973 | 0.0408 | |
| GSE53622 | TMEM59 | 9528 | 61908 | -0.6161 | 0.0000 | |
| GSE53624 | TMEM59 | 9528 | 61908 | -0.6285 | 0.0000 | |
| GSE63941 | TMEM59 | 9528 | 200620_at | -0.5473 | 0.1311 | |
| GSE77861 | TMEM59 | 9528 | 200620_at | -1.0997 | 0.0013 | |
| GSE97050 | TMEM59 | 9528 | A_23_P103282 | -0.1848 | 0.4490 | |
| SRP007169 | TMEM59 | 9528 | RNAseq | -2.5316 | 0.0000 | |
| SRP008496 | TMEM59 | 9528 | RNAseq | -2.2437 | 0.0000 | |
| SRP064894 | TMEM59 | 9528 | RNAseq | -0.9052 | 0.0000 | |
| SRP133303 | TMEM59 | 9528 | RNAseq | -0.5228 | 0.0042 | |
| SRP159526 | TMEM59 | 9528 | RNAseq | -0.5226 | 0.0785 | |
| SRP193095 | TMEM59 | 9528 | RNAseq | -1.1657 | 0.0000 | |
| SRP219564 | TMEM59 | 9528 | RNAseq | -0.9337 | 0.0150 | |
| TCGA | TMEM59 | 9528 | RNAseq | -0.2115 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by TMEM59 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMEM59:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMEM59 | 9528 | 3 | 4 | 23 | |
| GSE20123 | TMEM59 | 9528 | 3 | 3 | 24 | |
| GSE43470 | TMEM59 | 9528 | 6 | 2 | 35 | |
| GSE46452 | TMEM59 | 9528 | 2 | 1 | 56 | |
| GSE47630 | TMEM59 | 9528 | 8 | 4 | 28 | |
| GSE54993 | TMEM59 | 9528 | 0 | 0 | 70 | |
| GSE54994 | TMEM59 | 9528 | 10 | 2 | 41 | |
| GSE60625 | TMEM59 | 9528 | 0 | 0 | 11 | |
| GSE74703 | TMEM59 | 9528 | 4 | 1 | 31 | |
| GSE74704 | TMEM59 | 9528 | 2 | 0 | 18 | |
| TCGA | TMEM59 | 9528 | 10 | 18 | 68 |
Total number of gains: 48; Total number of losses: 35; Total Number of normals: 405.
Somatic mutations of TMEM59:
Generating mutation plots.
Highly correlated genes for TMEM59:
Showing top 20/1799 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMEM59 | SCP2 | 0.801951 | 12 | 0 | 12 |
| TMEM59 | ZCCHC9 | 0.795058 | 3 | 0 | 3 |
| TMEM59 | KCMF1 | 0.766353 | 3 | 0 | 3 |
| TMEM59 | SMIM14 | 0.759748 | 6 | 0 | 6 |
| TMEM59 | FAM214A | 0.757187 | 7 | 0 | 7 |
| TMEM59 | HBP1 | 0.752776 | 10 | 0 | 10 |
| TMEM59 | AK3 | 0.748634 | 7 | 0 | 7 |
| TMEM59 | PLEKHA7 | 0.748266 | 7 | 0 | 7 |
| TMEM59 | GPR108 | 0.746276 | 3 | 0 | 3 |
| TMEM59 | RHBDD1 | 0.745844 | 3 | 0 | 3 |
| TMEM59 | SH3GLB1 | 0.743503 | 11 | 0 | 11 |
| TMEM59 | RNF11 | 0.742146 | 12 | 0 | 11 |
| TMEM59 | BRWD3 | 0.741267 | 3 | 0 | 3 |
| TMEM59 | AP3M1 | 0.741057 | 4 | 0 | 4 |
| TMEM59 | PITHD1 | 0.73989 | 7 | 0 | 7 |
| TMEM59 | CTTNBP2NL | 0.739132 | 7 | 0 | 7 |
| TMEM59 | VPS29 | 0.736095 | 5 | 0 | 4 |
| TMEM59 | MAL2 | 0.735774 | 4 | 0 | 4 |
| TMEM59 | FAM71C | 0.733286 | 3 | 0 | 3 |
| TMEM59 | CMPK1 | 0.732823 | 13 | 0 | 11 |
For details and further investigation, click here
