| Full name: Ras suppressor protein 1 | Alias Symbol: RSP-1|FLJ31034 | ||
| Type: protein-coding gene | Cytoband: 10p13 | ||
| Entrez ID: 6251 | HGNC ID: HGNC:10464 | Ensembl Gene: ENSG00000148484 | OMIM ID: 179555 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RSU1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RSU1 | 6251 | 201980_s_at | -0.3252 | 0.4542 | |
| GSE20347 | RSU1 | 6251 | 201980_s_at | -0.6995 | 0.0014 | |
| GSE23400 | RSU1 | 6251 | 201980_s_at | -0.0828 | 0.3239 | |
| GSE26886 | RSU1 | 6251 | 201980_s_at | -0.2205 | 0.1567 | |
| GSE29001 | RSU1 | 6251 | 201980_s_at | -0.2180 | 0.3119 | |
| GSE38129 | RSU1 | 6251 | 201980_s_at | -0.5978 | 0.0003 | |
| GSE45670 | RSU1 | 6251 | 201980_s_at | -0.2394 | 0.2265 | |
| GSE53622 | RSU1 | 6251 | 58077 | -0.4757 | 0.0000 | |
| GSE53624 | RSU1 | 6251 | 58077 | -0.2249 | 0.0005 | |
| GSE63941 | RSU1 | 6251 | 201980_s_at | -1.6817 | 0.0314 | |
| GSE77861 | RSU1 | 6251 | 201980_s_at | -0.8194 | 0.0108 | |
| GSE97050 | RSU1 | 6251 | A_33_P3390335 | -0.2732 | 0.3837 | |
| SRP007169 | RSU1 | 6251 | RNAseq | -1.0566 | 0.0047 | |
| SRP008496 | RSU1 | 6251 | RNAseq | -0.8458 | 0.0000 | |
| SRP064894 | RSU1 | 6251 | RNAseq | -0.0554 | 0.7259 | |
| SRP133303 | RSU1 | 6251 | RNAseq | -0.3383 | 0.0732 | |
| SRP159526 | RSU1 | 6251 | RNAseq | -0.8239 | 0.0010 | |
| SRP193095 | RSU1 | 6251 | RNAseq | -0.4936 | 0.0000 | |
| SRP219564 | RSU1 | 6251 | RNAseq | -0.4309 | 0.3436 | |
| TCGA | RSU1 | 6251 | RNAseq | -0.0438 | 0.3988 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by RSU1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RSU1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RSU1 | 6251 | 3 | 8 | 19 | |
| GSE20123 | RSU1 | 6251 | 3 | 7 | 20 | |
| GSE43470 | RSU1 | 6251 | 3 | 5 | 35 | |
| GSE46452 | RSU1 | 6251 | 1 | 14 | 44 | |
| GSE47630 | RSU1 | 6251 | 5 | 15 | 20 | |
| GSE54993 | RSU1 | 6251 | 10 | 0 | 60 | |
| GSE54994 | RSU1 | 6251 | 4 | 9 | 40 | |
| GSE60625 | RSU1 | 6251 | 0 | 0 | 11 | |
| GSE74703 | RSU1 | 6251 | 2 | 3 | 31 | |
| GSE74704 | RSU1 | 6251 | 0 | 6 | 14 | |
| TCGA | RSU1 | 6251 | 20 | 26 | 50 |
Total number of gains: 51; Total number of losses: 93; Total Number of normals: 344.
Somatic mutations of RSU1:
Generating mutation plots.
Highly correlated genes for RSU1:
Showing top 20/596 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RSU1 | MSRB3 | 0.742636 | 3 | 0 | 3 |
| RSU1 | UBL5 | 0.711922 | 3 | 0 | 3 |
| RSU1 | NDUFA13 | 0.700253 | 4 | 0 | 4 |
| RSU1 | MRPS36 | 0.70015 | 5 | 0 | 4 |
| RSU1 | ZNF382 | 0.698324 | 3 | 0 | 3 |
| RSU1 | MRVI1 | 0.689448 | 4 | 0 | 3 |
| RSU1 | FIBIN | 0.687017 | 3 | 0 | 3 |
| RSU1 | TPM4 | 0.680935 | 4 | 0 | 4 |
| RSU1 | CACNA1C | 0.676971 | 4 | 0 | 4 |
| RSU1 | ACTR1A | 0.671418 | 8 | 0 | 7 |
| RSU1 | CCDC3 | 0.668397 | 3 | 0 | 3 |
| RSU1 | FBXO32 | 0.667837 | 3 | 0 | 3 |
| RSU1 | STARD9 | 0.66781 | 4 | 0 | 3 |
| RSU1 | RAB3GAP1 | 0.66764 | 3 | 0 | 3 |
| RSU1 | THUMPD3 | 0.665988 | 3 | 0 | 3 |
| RSU1 | FAM124A | 0.660461 | 3 | 0 | 3 |
| RSU1 | KLHL15 | 0.651927 | 3 | 0 | 3 |
| RSU1 | KIAA1143 | 0.65094 | 3 | 0 | 3 |
| RSU1 | NFATC4 | 0.647059 | 3 | 0 | 3 |
| RSU1 | RPL14 | 0.646765 | 4 | 0 | 4 |
For details and further investigation, click here
