| Full name: tropomyosin 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19p13.12-p13.11 | ||
| Entrez ID: 7171 | HGNC ID: HGNC:12013 | Ensembl Gene: ENSG00000167460 | OMIM ID: 600317 |
| Drug and gene relationship at DGIdb | |||
TPM4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04261 | Adrenergic signaling in cardiomyocytes |
Expression of TPM4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TPM4 | 7171 | 212481_s_at | -0.4579 | 0.4082 | |
| GSE20347 | TPM4 | 7171 | 209344_at | -0.5545 | 0.0200 | |
| GSE23400 | TPM4 | 7171 | 212481_s_at | -0.4924 | 0.0000 | |
| GSE26886 | TPM4 | 7171 | 212481_s_at | -1.3749 | 0.0027 | |
| GSE29001 | TPM4 | 7171 | 212481_s_at | -0.6282 | 0.2216 | |
| GSE38129 | TPM4 | 7171 | 209344_at | -0.1979 | 0.4029 | |
| GSE45670 | TPM4 | 7171 | 212481_s_at | 0.1391 | 0.5778 | |
| GSE53622 | TPM4 | 7171 | 86956 | 0.2342 | 0.0009 | |
| GSE53624 | TPM4 | 7171 | 86956 | 0.0627 | 0.3225 | |
| GSE63941 | TPM4 | 7171 | 212481_s_at | -1.5877 | 0.0270 | |
| GSE77861 | TPM4 | 7171 | 209344_at | 0.3035 | 0.3023 | |
| GSE97050 | TPM4 | 7171 | A_23_P141974 | 0.1756 | 0.4230 | |
| SRP007169 | TPM4 | 7171 | RNAseq | 0.6638 | 0.0563 | |
| SRP008496 | TPM4 | 7171 | RNAseq | 0.8042 | 0.0000 | |
| SRP064894 | TPM4 | 7171 | RNAseq | 0.0608 | 0.7440 | |
| SRP133303 | TPM4 | 7171 | RNAseq | 0.3075 | 0.1738 | |
| SRP159526 | TPM4 | 7171 | RNAseq | -0.1851 | 0.4840 | |
| SRP193095 | TPM4 | 7171 | RNAseq | 0.1931 | 0.2227 | |
| SRP219564 | TPM4 | 7171 | RNAseq | -0.0829 | 0.8183 | |
| TCGA | TPM4 | 7171 | RNAseq | 0.1350 | 0.0025 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by TPM4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TPM4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TPM4 | 7171 | 4 | 3 | 23 | |
| GSE20123 | TPM4 | 7171 | 3 | 2 | 25 | |
| GSE43470 | TPM4 | 7171 | 2 | 6 | 35 | |
| GSE46452 | TPM4 | 7171 | 47 | 1 | 11 | |
| GSE47630 | TPM4 | 7171 | 4 | 8 | 28 | |
| GSE54993 | TPM4 | 7171 | 15 | 4 | 51 | |
| GSE54994 | TPM4 | 7171 | 6 | 14 | 33 | |
| GSE60625 | TPM4 | 7171 | 9 | 0 | 2 | |
| GSE74703 | TPM4 | 7171 | 2 | 4 | 30 | |
| GSE74704 | TPM4 | 7171 | 0 | 1 | 19 | |
| TCGA | TPM4 | 7171 | 18 | 12 | 66 |
Total number of gains: 110; Total number of losses: 55; Total Number of normals: 323.
Somatic mutations of TPM4:
Generating mutation plots.
Highly correlated genes for TPM4:
Showing top 20/355 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TPM4 | MRPL46 | 0.765587 | 3 | 0 | 3 |
| TPM4 | LDHD | 0.74412 | 3 | 0 | 3 |
| TPM4 | SLC46A2 | 0.726694 | 3 | 0 | 3 |
| TPM4 | DDX1 | 0.718278 | 3 | 0 | 3 |
| TPM4 | EPG5 | 0.718015 | 3 | 0 | 3 |
| TPM4 | PIGF | 0.706187 | 3 | 0 | 3 |
| TPM4 | ZBED6 | 0.700685 | 3 | 0 | 3 |
| TPM4 | USP40 | 0.698642 | 3 | 0 | 3 |
| TPM4 | SLC16A14 | 0.695501 | 3 | 0 | 3 |
| TPM4 | GANC | 0.693838 | 4 | 0 | 4 |
| TPM4 | CDKAL1 | 0.683922 | 3 | 0 | 3 |
| TPM4 | RSU1 | 0.680935 | 4 | 0 | 4 |
| TPM4 | PSMD7 | 0.676692 | 4 | 0 | 3 |
| TPM4 | ATG4A | 0.675865 | 3 | 0 | 3 |
| TPM4 | DIXDC1 | 0.674098 | 3 | 0 | 3 |
| TPM4 | HCCS | 0.673233 | 3 | 0 | 3 |
| TPM4 | ZDHHC21 | 0.671773 | 3 | 0 | 3 |
| TPM4 | SCO1 | 0.668993 | 3 | 0 | 3 |
| TPM4 | CCNYL1 | 0.665217 | 4 | 0 | 3 |
| TPM4 | LYSMD3 | 0.663986 | 4 | 0 | 3 |
For details and further investigation, click here
