| Full name: F-box protein 32 | Alias Symbol: MAFbx|ATROGIN1|Fbx32 | ||
| Type: protein-coding gene | Cytoband: 8q24.13 | ||
| Entrez ID: 114907 | HGNC ID: HGNC:16731 | Ensembl Gene: ENSG00000156804 | OMIM ID: 606604 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
FBXO32 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway |
Expression of FBXO32:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBXO32 | 114907 | 225803_at | -0.5993 | 0.6962 | |
| GSE26886 | FBXO32 | 114907 | 225803_at | -1.3392 | 0.0131 | |
| GSE45670 | FBXO32 | 114907 | 225803_at | -0.5561 | 0.0391 | |
| GSE53622 | FBXO32 | 114907 | 112964 | -0.3143 | 0.0210 | |
| GSE53624 | FBXO32 | 114907 | 112964 | -0.4401 | 0.0000 | |
| GSE63941 | FBXO32 | 114907 | 225803_at | 0.4195 | 0.7595 | |
| GSE77861 | FBXO32 | 114907 | 225803_at | -0.9203 | 0.0285 | |
| GSE97050 | FBXO32 | 114907 | A_33_P3378126 | -0.5834 | 0.1399 | |
| SRP007169 | FBXO32 | 114907 | RNAseq | -1.4024 | 0.0082 | |
| SRP008496 | FBXO32 | 114907 | RNAseq | -0.9616 | 0.0299 | |
| SRP064894 | FBXO32 | 114907 | RNAseq | 0.1438 | 0.5919 | |
| SRP133303 | FBXO32 | 114907 | RNAseq | 0.3153 | 0.3886 | |
| SRP159526 | FBXO32 | 114907 | RNAseq | 0.4275 | 0.3209 | |
| SRP193095 | FBXO32 | 114907 | RNAseq | -0.4784 | 0.0954 | |
| SRP219564 | FBXO32 | 114907 | RNAseq | 0.1048 | 0.8666 | |
| TCGA | FBXO32 | 114907 | RNAseq | 0.0536 | 0.6647 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by FBXO32 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBXO32:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBXO32 | 114907 | 19 | 0 | 11 | |
| GSE20123 | FBXO32 | 114907 | 20 | 0 | 10 | |
| GSE43470 | FBXO32 | 114907 | 22 | 0 | 21 | |
| GSE46452 | FBXO32 | 114907 | 27 | 0 | 32 | |
| GSE47630 | FBXO32 | 114907 | 24 | 0 | 16 | |
| GSE54993 | FBXO32 | 114907 | 0 | 21 | 49 | |
| GSE54994 | FBXO32 | 114907 | 37 | 1 | 15 | |
| GSE60625 | FBXO32 | 114907 | 0 | 4 | 7 | |
| GSE74703 | FBXO32 | 114907 | 19 | 0 | 17 | |
| GSE74704 | FBXO32 | 114907 | 13 | 0 | 7 | |
| TCGA | FBXO32 | 114907 | 67 | 1 | 28 |
Total number of gains: 248; Total number of losses: 27; Total Number of normals: 213.
Somatic mutations of FBXO32:
Generating mutation plots.
Highly correlated genes for FBXO32:
Showing top 20/506 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBXO32 | ZNF274 | 0.737009 | 3 | 0 | 3 |
| FBXO32 | LSM11 | 0.733361 | 3 | 0 | 3 |
| FBXO32 | HDHD2 | 0.726745 | 3 | 0 | 3 |
| FBXO32 | GPRASP1 | 0.720607 | 3 | 0 | 3 |
| FBXO32 | ARG2 | 0.717334 | 3 | 0 | 3 |
| FBXO32 | FBXO31 | 0.714992 | 3 | 0 | 3 |
| FBXO32 | EPB41 | 0.711051 | 3 | 0 | 3 |
| FBXO32 | POLH | 0.709772 | 3 | 0 | 3 |
| FBXO32 | ITCH | 0.707303 | 4 | 0 | 4 |
| FBXO32 | CLDN2 | 0.705783 | 3 | 0 | 3 |
| FBXO32 | ZNF416 | 0.705678 | 3 | 0 | 3 |
| FBXO32 | ACTR1A | 0.704551 | 3 | 0 | 3 |
| FBXO32 | HMGN1 | 0.704165 | 3 | 0 | 3 |
| FBXO32 | FXYD6 | 0.702758 | 3 | 0 | 3 |
| FBXO32 | RCOR3 | 0.701258 | 3 | 0 | 3 |
| FBXO32 | VEZF1 | 0.70063 | 3 | 0 | 3 |
| FBXO32 | RUNX1T1 | 0.699581 | 3 | 0 | 3 |
| FBXO32 | USP9Y | 0.698176 | 3 | 0 | 3 |
| FBXO32 | JAM3 | 0.696868 | 3 | 0 | 3 |
| FBXO32 | TMEM170B | 0.692826 | 3 | 0 | 3 |
For details and further investigation, click here
