| Full name: RUN and SH3 domain containing 1 | Alias Symbol: NESCA | ||
| Type: protein-coding gene | Cytoband: 1q22 | ||
| Entrez ID: 23623 | HGNC ID: HGNC:17153 | Ensembl Gene: ENSG00000160753 | OMIM ID: 617318 |
| Drug and gene relationship at DGIdb | |||
Expression of RUSC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RUSC1 | 23623 | 206949_s_at | 0.1369 | 0.8057 | |
| GSE20347 | RUSC1 | 23623 | 206949_s_at | -0.2837 | 0.0341 | |
| GSE23400 | RUSC1 | 23623 | 206949_s_at | -0.0592 | 0.2216 | |
| GSE26886 | RUSC1 | 23623 | 206949_s_at | -0.6679 | 0.0027 | |
| GSE29001 | RUSC1 | 23623 | 206949_s_at | -0.1145 | 0.7642 | |
| GSE38129 | RUSC1 | 23623 | 206949_s_at | -0.1105 | 0.3917 | |
| GSE45670 | RUSC1 | 23623 | 206949_s_at | -0.0522 | 0.7053 | |
| GSE53622 | RUSC1 | 23623 | 12161 | -0.1002 | 0.2182 | |
| GSE53624 | RUSC1 | 23623 | 12161 | -0.1867 | 0.0022 | |
| GSE63941 | RUSC1 | 23623 | 206949_s_at | 0.5824 | 0.1490 | |
| GSE77861 | RUSC1 | 23623 | 206949_s_at | 0.0309 | 0.9269 | |
| GSE97050 | RUSC1 | 23623 | A_24_P2948 | 0.1604 | 0.4507 | |
| SRP007169 | RUSC1 | 23623 | RNAseq | -1.0759 | 0.0074 | |
| SRP008496 | RUSC1 | 23623 | RNAseq | -0.5442 | 0.0232 | |
| SRP064894 | RUSC1 | 23623 | RNAseq | 0.1852 | 0.3801 | |
| SRP133303 | RUSC1 | 23623 | RNAseq | -0.0734 | 0.6790 | |
| SRP159526 | RUSC1 | 23623 | RNAseq | 0.1387 | 0.6234 | |
| SRP193095 | RUSC1 | 23623 | RNAseq | -0.0114 | 0.9118 | |
| SRP219564 | RUSC1 | 23623 | RNAseq | 0.3551 | 0.4017 | |
| TCGA | RUSC1 | 23623 | RNAseq | 0.1530 | 0.0023 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by RUSC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RUSC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RUSC1 | 23623 | 14 | 0 | 16 | |
| GSE20123 | RUSC1 | 23623 | 13 | 0 | 17 | |
| GSE43470 | RUSC1 | 23623 | 7 | 3 | 33 | |
| GSE46452 | RUSC1 | 23623 | 2 | 1 | 56 | |
| GSE47630 | RUSC1 | 23623 | 14 | 0 | 26 | |
| GSE54993 | RUSC1 | 23623 | 0 | 4 | 66 | |
| GSE54994 | RUSC1 | 23623 | 16 | 0 | 37 | |
| GSE60625 | RUSC1 | 23623 | 0 | 0 | 11 | |
| GSE74703 | RUSC1 | 23623 | 7 | 2 | 27 | |
| GSE74704 | RUSC1 | 23623 | 6 | 0 | 14 | |
| TCGA | RUSC1 | 23623 | 38 | 2 | 56 |
Total number of gains: 117; Total number of losses: 12; Total Number of normals: 359.
Somatic mutations of RUSC1:
Generating mutation plots.
Highly correlated genes for RUSC1:
Showing top 20/202 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RUSC1 | CLEC18C | 0.754132 | 3 | 0 | 3 |
| RUSC1 | CYB561D1 | 0.743376 | 3 | 0 | 3 |
| RUSC1 | VIPR2 | 0.711069 | 3 | 0 | 3 |
| RUSC1 | DCD | 0.710361 | 3 | 0 | 3 |
| RUSC1 | ZNF687 | 0.703444 | 4 | 0 | 3 |
| RUSC1 | TMEM102 | 0.699783 | 3 | 0 | 3 |
| RUSC1 | DNAL4 | 0.694238 | 3 | 0 | 3 |
| RUSC1 | ZDHHC20 | 0.69363 | 3 | 0 | 3 |
| RUSC1 | RPIA | 0.689239 | 3 | 0 | 3 |
| RUSC1 | RFT1 | 0.685456 | 3 | 0 | 3 |
| RUSC1 | BRI3BP | 0.680412 | 3 | 0 | 3 |
| RUSC1 | JMJD8 | 0.677356 | 3 | 0 | 3 |
| RUSC1 | C1QL1 | 0.673929 | 4 | 0 | 4 |
| RUSC1 | POMT2 | 0.661673 | 4 | 0 | 3 |
| RUSC1 | NOTO | 0.660447 | 3 | 0 | 3 |
| RUSC1 | ETV3 | 0.658531 | 3 | 0 | 3 |
| RUSC1 | BCAP31 | 0.656328 | 5 | 0 | 4 |
| RUSC1 | MAPKAPK3 | 0.654297 | 5 | 0 | 4 |
| RUSC1 | PKD2L1 | 0.654141 | 4 | 0 | 3 |
| RUSC1 | SDR42E1 | 0.651587 | 3 | 0 | 3 |
For details and further investigation, click here
