| Full name: MAPK activated protein kinase 3 | Alias Symbol: 3pK|MAPKAP3|3PK | ||
| Type: protein-coding gene | Cytoband: 3p21.2 | ||
| Entrez ID: 7867 | HGNC ID: HGNC:6888 | Ensembl Gene: ENSG00000114738 | OMIM ID: 602130 |
| Drug and gene relationship at DGIdb | |||
MAPKAPK3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04370 | VEGF signaling pathway |
Expression of MAPKAPK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAPKAPK3 | 7867 | 202788_at | -0.2466 | 0.4961 | |
| GSE20347 | MAPKAPK3 | 7867 | 202788_at | -0.8727 | 0.0000 | |
| GSE23400 | MAPKAPK3 | 7867 | 202788_at | -0.5459 | 0.0000 | |
| GSE26886 | MAPKAPK3 | 7867 | 202788_at | -1.3928 | 0.0000 | |
| GSE29001 | MAPKAPK3 | 7867 | 202788_at | -0.7812 | 0.0004 | |
| GSE38129 | MAPKAPK3 | 7867 | 202788_at | -0.7402 | 0.0000 | |
| GSE45670 | MAPKAPK3 | 7867 | 202788_at | -0.2275 | 0.0550 | |
| GSE53622 | MAPKAPK3 | 7867 | 9380 | -0.9257 | 0.0000 | |
| GSE53624 | MAPKAPK3 | 7867 | 9380 | -0.9697 | 0.0000 | |
| GSE63941 | MAPKAPK3 | 7867 | 202788_at | 0.0762 | 0.8693 | |
| GSE77861 | MAPKAPK3 | 7867 | 202788_at | -0.7139 | 0.0160 | |
| GSE97050 | MAPKAPK3 | 7867 | A_23_P314584 | -0.0185 | 0.9412 | |
| SRP007169 | MAPKAPK3 | 7867 | RNAseq | -1.7825 | 0.0000 | |
| SRP008496 | MAPKAPK3 | 7867 | RNAseq | -1.7318 | 0.0000 | |
| SRP064894 | MAPKAPK3 | 7867 | RNAseq | -0.9620 | 0.0000 | |
| SRP133303 | MAPKAPK3 | 7867 | RNAseq | -1.0808 | 0.0000 | |
| SRP159526 | MAPKAPK3 | 7867 | RNAseq | -0.9929 | 0.0179 | |
| SRP193095 | MAPKAPK3 | 7867 | RNAseq | -1.1006 | 0.0000 | |
| SRP219564 | MAPKAPK3 | 7867 | RNAseq | -0.9949 | 0.0096 | |
| TCGA | MAPKAPK3 | 7867 | RNAseq | -0.2914 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by MAPKAPK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAPKAPK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAPKAPK3 | 7867 | 0 | 18 | 12 | |
| GSE20123 | MAPKAPK3 | 7867 | 0 | 19 | 11 | |
| GSE43470 | MAPKAPK3 | 7867 | 0 | 19 | 24 | |
| GSE46452 | MAPKAPK3 | 7867 | 2 | 16 | 41 | |
| GSE47630 | MAPKAPK3 | 7867 | 1 | 24 | 15 | |
| GSE54993 | MAPKAPK3 | 7867 | 6 | 2 | 62 | |
| GSE54994 | MAPKAPK3 | 7867 | 0 | 34 | 19 | |
| GSE60625 | MAPKAPK3 | 7867 | 5 | 0 | 6 | |
| GSE74703 | MAPKAPK3 | 7867 | 0 | 15 | 21 | |
| GSE74704 | MAPKAPK3 | 7867 | 0 | 12 | 8 | |
| TCGA | MAPKAPK3 | 7867 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 237; Total Number of normals: 237.
Somatic mutations of MAPKAPK3:
Generating mutation plots.
Highly correlated genes for MAPKAPK3:
Showing top 20/791 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAPKAPK3 | GPR78 | 0.801303 | 3 | 0 | 3 |
| MAPKAPK3 | CLIC3 | 0.793156 | 8 | 0 | 8 |
| MAPKAPK3 | SPNS2 | 0.769571 | 4 | 0 | 4 |
| MAPKAPK3 | DEGS2 | 0.767744 | 7 | 0 | 7 |
| MAPKAPK3 | SULT2B1 | 0.765012 | 9 | 0 | 9 |
| MAPKAPK3 | CES2 | 0.761684 | 9 | 0 | 9 |
| MAPKAPK3 | PRSS27 | 0.760693 | 7 | 0 | 7 |
| MAPKAPK3 | SLC35C1 | 0.759149 | 11 | 0 | 11 |
| MAPKAPK3 | CYSRT1 | 0.752123 | 6 | 0 | 6 |
| MAPKAPK3 | ANKRD22 | 0.752078 | 4 | 0 | 4 |
| MAPKAPK3 | MYO5B | 0.749248 | 7 | 0 | 7 |
| MAPKAPK3 | ENDOU | 0.748791 | 10 | 0 | 10 |
| MAPKAPK3 | PTK6 | 0.748046 | 12 | 0 | 12 |
| MAPKAPK3 | SFTA2 | 0.745725 | 4 | 0 | 4 |
| MAPKAPK3 | EPS8L2 | 0.745003 | 11 | 0 | 11 |
| MAPKAPK3 | CWH43 | 0.743224 | 10 | 0 | 10 |
| MAPKAPK3 | FAM3D | 0.742391 | 6 | 0 | 6 |
| MAPKAPK3 | FAM95B1 | 0.741221 | 3 | 0 | 3 |
| MAPKAPK3 | CAPN14 | 0.735844 | 6 | 0 | 6 |
| MAPKAPK3 | TMEM40 | 0.733471 | 10 | 0 | 10 |
For details and further investigation, click here
