| Full name: scavenger receptor class B member 1 | Alias Symbol: SRB1|CLA-1|CLA1|SR-BI | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 949 | HGNC ID: HGNC:1664 | Ensembl Gene: ENSG00000073060 | OMIM ID: 601040 |
| Drug and gene relationship at DGIdb | |||
Expression of SCARB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCARB1 | 949 | 1552256_a_at | 1.4012 | 0.0384 | |
| GSE20347 | SCARB1 | 949 | 201819_at | 1.1116 | 0.0000 | |
| GSE23400 | SCARB1 | 949 | 201819_at | 0.2533 | 0.0005 | |
| GSE26886 | SCARB1 | 949 | 1552256_a_at | 1.0055 | 0.0000 | |
| GSE29001 | SCARB1 | 949 | 201819_at | 0.5478 | 0.0292 | |
| GSE38129 | SCARB1 | 949 | 201819_at | 0.9409 | 0.0000 | |
| GSE45670 | SCARB1 | 949 | 1552256_a_at | 0.5777 | 0.0032 | |
| GSE53622 | SCARB1 | 949 | 60833 | 0.1620 | 0.0119 | |
| GSE53624 | SCARB1 | 949 | 60833 | 0.1745 | 0.1251 | |
| GSE63941 | SCARB1 | 949 | 1552256_a_at | 0.8725 | 0.1487 | |
| GSE77861 | SCARB1 | 949 | 1552256_a_at | 1.1001 | 0.0212 | |
| GSE97050 | SCARB1 | 949 | A_23_P203900 | 0.5419 | 0.1489 | |
| SRP007169 | SCARB1 | 949 | RNAseq | 1.6288 | 0.0003 | |
| SRP008496 | SCARB1 | 949 | RNAseq | 1.7256 | 0.0004 | |
| SRP064894 | SCARB1 | 949 | RNAseq | 0.7154 | 0.0008 | |
| SRP133303 | SCARB1 | 949 | RNAseq | 0.2518 | 0.1810 | |
| SRP159526 | SCARB1 | 949 | RNAseq | 1.6870 | 0.0031 | |
| SRP193095 | SCARB1 | 949 | RNAseq | 0.7244 | 0.0000 | |
| SRP219564 | SCARB1 | 949 | RNAseq | 0.3351 | 0.4122 | |
| TCGA | SCARB1 | 949 | RNAseq | 0.3421 | 0.0001 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by SCARB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCARB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCARB1 | 949 | 5 | 5 | 20 | |
| GSE20123 | SCARB1 | 949 | 5 | 5 | 20 | |
| GSE43470 | SCARB1 | 949 | 2 | 0 | 41 | |
| GSE46452 | SCARB1 | 949 | 9 | 1 | 49 | |
| GSE47630 | SCARB1 | 949 | 9 | 3 | 28 | |
| GSE54993 | SCARB1 | 949 | 0 | 5 | 65 | |
| GSE54994 | SCARB1 | 949 | 4 | 8 | 41 | |
| GSE60625 | SCARB1 | 949 | 0 | 0 | 11 | |
| GSE74703 | SCARB1 | 949 | 2 | 0 | 34 | |
| GSE74704 | SCARB1 | 949 | 3 | 3 | 14 | |
| TCGA | SCARB1 | 949 | 21 | 12 | 63 |
Total number of gains: 60; Total number of losses: 42; Total Number of normals: 386.
Somatic mutations of SCARB1:
Generating mutation plots.
Highly correlated genes for SCARB1:
Showing top 20/1451 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCARB1 | OCIAD2 | 0.811264 | 4 | 0 | 4 |
| SCARB1 | DDX55 | 0.796209 | 4 | 0 | 4 |
| SCARB1 | DNAJB11 | 0.794491 | 3 | 0 | 3 |
| SCARB1 | UTP23 | 0.776388 | 3 | 0 | 3 |
| SCARB1 | CLPTM1L | 0.767028 | 4 | 0 | 4 |
| SCARB1 | TP53I13 | 0.763049 | 4 | 0 | 4 |
| SCARB1 | KRTCAP2 | 0.760826 | 5 | 0 | 5 |
| SCARB1 | GNPNAT1 | 0.75687 | 3 | 0 | 3 |
| SCARB1 | B3GALT6 | 0.756706 | 4 | 0 | 4 |
| SCARB1 | NSUN2 | 0.755575 | 4 | 0 | 4 |
| SCARB1 | CCDC18 | 0.754885 | 3 | 0 | 3 |
| SCARB1 | TOP1MT | 0.746994 | 5 | 0 | 4 |
| SCARB1 | SLC46A1 | 0.736474 | 3 | 0 | 3 |
| SCARB1 | KIAA1324L | 0.731392 | 3 | 0 | 3 |
| SCARB1 | FMNL2 | 0.720704 | 5 | 0 | 5 |
| SCARB1 | THUMPD2 | 0.72063 | 4 | 0 | 3 |
| SCARB1 | KRTAP19-2 | 0.720602 | 3 | 0 | 3 |
| SCARB1 | TSPAN17 | 0.714506 | 3 | 0 | 3 |
| SCARB1 | CTHRC1 | 0.714502 | 5 | 0 | 5 |
| SCARB1 | FUCA2 | 0.714431 | 4 | 0 | 4 |
For details and further investigation, click here
