THUMPD2

 

Full name: THUMP domain containing 2 Alias Symbol: MGC2454
Type: protein-coding gene Cytoband: 2p22.1
Entrez ID: 80745 HGNC ID: HGNC:14890 Ensembl Gene: ENSG00000138050 OMIM ID: 611751
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of THUMPD2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 THUMPD2 80745 219248_at 0.3663 0.3093
GSE20347 THUMPD2 80745 219248_at 0.3448 0.0079
GSE23400 THUMPD2 80745 219248_at 0.2276 0.0000
GSE26886 THUMPD2 80745 219248_at 0.2525 0.3063
GSE29001 THUMPD2 80745 219248_at 0.0649 0.8026
GSE38129 THUMPD2 80745 219248_at 0.3993 0.0017
GSE45670 THUMPD2 80745 219248_at 0.0509 0.7889
GSE53622 THUMPD2 80745 51787 0.2559 0.0016
GSE53624 THUMPD2 80745 51787 0.2080 0.0089
GSE63941 THUMPD2 80745 219248_at 0.5342 0.1585
GSE77861 THUMPD2 80745 219248_at 0.5007 0.0234
GSE97050 THUMPD2 80745 A_33_P3424384 0.0561 0.8456
SRP007169 THUMPD2 80745 RNAseq -0.5214 0.2151
SRP008496 THUMPD2 80745 RNAseq -0.2422 0.3974
SRP064894 THUMPD2 80745 RNAseq 0.0331 0.7859
SRP133303 THUMPD2 80745 RNAseq 0.2591 0.1446
SRP159526 THUMPD2 80745 RNAseq 0.1192 0.6588
SRP193095 THUMPD2 80745 RNAseq 0.0427 0.7112
SRP219564 THUMPD2 80745 RNAseq 0.2773 0.5027
TCGA THUMPD2 80745 RNAseq 0.1823 0.0047

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by THUMPD2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of THUMPD2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 THUMPD2 80745 10 1 19
GSE20123 THUMPD2 80745 9 1 20
GSE43470 THUMPD2 80745 3 0 40
GSE46452 THUMPD2 80745 1 4 54
GSE47630 THUMPD2 80745 7 0 33
GSE54993 THUMPD2 80745 0 5 65
GSE54994 THUMPD2 80745 10 0 43
GSE60625 THUMPD2 80745 0 3 8
GSE74703 THUMPD2 80745 3 0 33
GSE74704 THUMPD2 80745 9 1 10
TCGA THUMPD2 80745 36 2 58

Total number of gains: 88; Total number of losses: 17; Total Number of normals: 383.  

 

Somatic mutations of THUMPD2:

 

Generating mutation plots.

 

Highly correlated genes for THUMPD2:

 

Showing top 20/945 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
THUMPD2KRTCAP20.854742303
THUMPD2DNAH140.79903303
THUMPD2NAP1L10.791991303
THUMPD2GLRX20.772772303
THUMPD2TIGD10.765556303
THUMPD2GSR0.75876303
THUMPD2BRAT10.754946303
THUMPD2TTC140.739828303
THUMPD2ACVR1C0.737396303
THUMPD2MED40.736884303
THUMPD2UBQLN40.729413303
THUMPD2MRPS90.729275303
THUMPD2P2RX40.728612303
THUMPD2TEX90.728444303
THUMPD2SCARB10.72063403
THUMPD2IMMP1L0.718548404
THUMPD2BDP10.710745303
THUMPD2EFTUD20.710502303
THUMPD2DHX370.70726303
THUMPD2CDCA70.703979403

For details and further investigation, click here