| Full name: NOP2/Sun RNA methyltransferase 2 | Alias Symbol: FLJ20303|TRM4|Misu | ||
| Type: protein-coding gene | Cytoband: 5p15.31 | ||
| Entrez ID: 54888 | HGNC ID: HGNC:25994 | Ensembl Gene: ENSG00000037474 | OMIM ID: 610916 |
| Drug and gene relationship at DGIdb | |||
Expression of NSUN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NSUN2 | 54888 | 223076_s_at | 0.8575 | 0.0579 | |
| GSE26886 | NSUN2 | 54888 | 223076_s_at | 0.3962 | 0.0135 | |
| GSE45670 | NSUN2 | 54888 | 223076_s_at | 0.6298 | 0.0013 | |
| GSE53622 | NSUN2 | 54888 | 53581 | 0.6552 | 0.0000 | |
| GSE53624 | NSUN2 | 54888 | 53581 | 0.8030 | 0.0000 | |
| GSE63941 | NSUN2 | 54888 | 223076_s_at | 0.7383 | 0.0319 | |
| GSE77861 | NSUN2 | 54888 | 223076_s_at | 0.8703 | 0.0073 | |
| GSE97050 | NSUN2 | 54888 | A_23_P7423 | 0.6426 | 0.1782 | |
| SRP007169 | NSUN2 | 54888 | RNAseq | 1.8880 | 0.0000 | |
| SRP008496 | NSUN2 | 54888 | RNAseq | 1.5123 | 0.0000 | |
| SRP064894 | NSUN2 | 54888 | RNAseq | 0.3439 | 0.0912 | |
| SRP133303 | NSUN2 | 54888 | RNAseq | 0.7253 | 0.0011 | |
| SRP159526 | NSUN2 | 54888 | RNAseq | 0.6091 | 0.0556 | |
| SRP193095 | NSUN2 | 54888 | RNAseq | 0.5702 | 0.0000 | |
| SRP219564 | NSUN2 | 54888 | RNAseq | 0.5961 | 0.1640 | |
| TCGA | NSUN2 | 54888 | RNAseq | 0.2186 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by NSUN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NSUN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NSUN2 | 54888 | 13 | 0 | 17 | |
| GSE20123 | NSUN2 | 54888 | 13 | 1 | 16 | |
| GSE43470 | NSUN2 | 54888 | 16 | 0 | 27 | |
| GSE46452 | NSUN2 | 54888 | 6 | 22 | 31 | |
| GSE47630 | NSUN2 | 54888 | 6 | 11 | 23 | |
| GSE54993 | NSUN2 | 54888 | 5 | 5 | 60 | |
| GSE54994 | NSUN2 | 54888 | 29 | 1 | 23 | |
| GSE60625 | NSUN2 | 54888 | 0 | 0 | 11 | |
| GSE74703 | NSUN2 | 54888 | 12 | 0 | 24 | |
| GSE74704 | NSUN2 | 54888 | 11 | 0 | 9 | |
| TCGA | NSUN2 | 54888 | 57 | 4 | 35 |
Total number of gains: 168; Total number of losses: 44; Total Number of normals: 276.
Somatic mutations of NSUN2:
Generating mutation plots.
Highly correlated genes for NSUN2:
Showing top 20/1252 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NSUN2 | MYO10 | 0.7577 | 5 | 0 | 4 |
| NSUN2 | SCARB1 | 0.755575 | 4 | 0 | 4 |
| NSUN2 | EIF3B | 0.755014 | 5 | 0 | 5 |
| NSUN2 | BMS1 | 0.754034 | 4 | 0 | 4 |
| NSUN2 | LPCAT1 | 0.726511 | 7 | 0 | 7 |
| NSUN2 | CCT5 | 0.722128 | 6 | 0 | 5 |
| NSUN2 | TRIP13 | 0.718453 | 9 | 0 | 9 |
| NSUN2 | MTERF3 | 0.709421 | 4 | 0 | 4 |
| NSUN2 | CCT3 | 0.707825 | 5 | 0 | 5 |
| NSUN2 | INTS1 | 0.706011 | 3 | 0 | 3 |
| NSUN2 | GOLM1 | 0.704959 | 3 | 0 | 3 |
| NSUN2 | MED10 | 0.703387 | 8 | 0 | 8 |
| NSUN2 | ACVR1C | 0.70067 | 4 | 0 | 3 |
| NSUN2 | BRIX1 | 0.700386 | 9 | 0 | 8 |
| NSUN2 | CBX3 | 0.696093 | 6 | 0 | 6 |
| NSUN2 | PTK7 | 0.694719 | 7 | 0 | 6 |
| NSUN2 | MRGBP | 0.692858 | 5 | 0 | 5 |
| NSUN2 | MFSD12 | 0.692759 | 3 | 0 | 3 |
| NSUN2 | U2SURP | 0.691131 | 5 | 0 | 4 |
| NSUN2 | FEN1 | 0.687914 | 4 | 0 | 4 |
For details and further investigation, click here
