| Full name: sodium voltage-gated channel alpha subunit 10 | Alias Symbol: Nav1.8|hPN3|SNS|PN3 | ||
| Type: protein-coding gene | Cytoband: 3p22.2 | ||
| Entrez ID: 6336 | HGNC ID: HGNC:10582 | Ensembl Gene: ENSG00000185313 | OMIM ID: 604427 |
| Drug and gene relationship at DGIdb | |||
Expression of SCN10A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCN10A | 6336 | 208578_at | -0.0405 | 0.8494 | |
| GSE20347 | SCN10A | 6336 | 208578_at | -0.0466 | 0.6546 | |
| GSE23400 | SCN10A | 6336 | 208578_at | -0.0822 | 0.0991 | |
| GSE26886 | SCN10A | 6336 | 208578_at | -0.2357 | 0.0660 | |
| GSE29001 | SCN10A | 6336 | 208578_at | -0.1593 | 0.2657 | |
| GSE38129 | SCN10A | 6336 | 208578_at | -0.1153 | 0.1626 | |
| GSE45670 | SCN10A | 6336 | 208578_at | 0.0214 | 0.8442 | |
| GSE53622 | SCN10A | 6336 | 48394 | 1.2981 | 0.0000 | |
| GSE53624 | SCN10A | 6336 | 48394 | 1.6035 | 0.0000 | |
| GSE63941 | SCN10A | 6336 | 208578_at | 0.2570 | 0.0690 | |
| GSE77861 | SCN10A | 6336 | 208578_at | -0.2238 | 0.1150 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SCN10A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCN10A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCN10A | 6336 | 0 | 19 | 11 | |
| GSE20123 | SCN10A | 6336 | 0 | 19 | 11 | |
| GSE43470 | SCN10A | 6336 | 0 | 20 | 23 | |
| GSE46452 | SCN10A | 6336 | 2 | 17 | 40 | |
| GSE47630 | SCN10A | 6336 | 1 | 25 | 14 | |
| GSE54993 | SCN10A | 6336 | 7 | 2 | 61 | |
| GSE54994 | SCN10A | 6336 | 0 | 34 | 19 | |
| GSE60625 | SCN10A | 6336 | 5 | 0 | 6 | |
| GSE74703 | SCN10A | 6336 | 0 | 16 | 20 | |
| GSE74704 | SCN10A | 6336 | 0 | 13 | 7 | |
| TCGA | SCN10A | 6336 | 1 | 71 | 24 |
Total number of gains: 16; Total number of losses: 236; Total Number of normals: 236.
Somatic mutations of SCN10A:
Generating mutation plots.
Highly correlated genes for SCN10A:
Showing top 20/637 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCN10A | APBA1 | 0.724683 | 3 | 0 | 3 |
| SCN10A | C3orf62 | 0.72193 | 3 | 0 | 3 |
| SCN10A | MAP3K19 | 0.704082 | 7 | 0 | 7 |
| SCN10A | CCDC9 | 0.700687 | 3 | 0 | 3 |
| SCN10A | SPATA24 | 0.693624 | 4 | 0 | 4 |
| SCN10A | MC4R | 0.685967 | 3 | 0 | 3 |
| SCN10A | KIR3DL3 | 0.685764 | 5 | 0 | 4 |
| SCN10A | UNC79 | 0.684185 | 3 | 0 | 3 |
| SCN10A | CCZ1 | 0.682791 | 4 | 0 | 4 |
| SCN10A | SIRPG | 0.679766 | 4 | 0 | 4 |
| SCN10A | AMELY | 0.679219 | 3 | 0 | 3 |
| SCN10A | TERT | 0.67811 | 4 | 0 | 4 |
| SCN10A | TNFRSF13B | 0.6778 | 3 | 0 | 3 |
| SCN10A | OTOR | 0.677009 | 3 | 0 | 3 |
| SCN10A | KIR2DL1 | 0.674548 | 3 | 0 | 3 |
| SCN10A | SERPINA6 | 0.670236 | 3 | 0 | 3 |
| SCN10A | NPAP1 | 0.66832 | 3 | 0 | 3 |
| SCN10A | NTSR2 | 0.667174 | 3 | 0 | 3 |
| SCN10A | OR1F1 | 0.666697 | 3 | 0 | 3 |
| SCN10A | TRPM3 | 0.665169 | 4 | 0 | 4 |
For details and further investigation, click here
