| Full name: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 | Alias Symbol: cl-42|nkat1|47.11|p58.1|CD158A | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 3802 | HGNC ID: HGNC:6329 | Ensembl Gene: ENSG00000125498 | OMIM ID: 604936 |
| Drug and gene relationship at DGIdb | |||
KIR2DL1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa04650 | Natural killer cell mediated cytotoxicity |
Expression of KIR2DL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KIR2DL1 | 3802 | 210890_x_at | 0.2071 | 0.3977 | |
| GSE20347 | KIR2DL1 | 3802 | 210890_x_at | 0.0959 | 0.3339 | |
| GSE23400 | KIR2DL1 | 3802 | 210890_x_at | -0.0338 | 0.4027 | |
| GSE26886 | KIR2DL1 | 3802 | 210890_x_at | 0.0417 | 0.7411 | |
| GSE29001 | KIR2DL1 | 3802 | 210890_x_at | 0.0370 | 0.7962 | |
| GSE38129 | KIR2DL1 | 3802 | 210890_x_at | -0.0299 | 0.8089 | |
| GSE45670 | KIR2DL1 | 3802 | 210890_x_at | 0.2082 | 0.0228 | |
| GSE53622 | KIR2DL1 | 3802 | 78029 | 0.4028 | 0.0135 | |
| GSE53624 | KIR2DL1 | 3802 | 78029 | 0.5256 | 0.0006 | |
| GSE63941 | KIR2DL1 | 3802 | 210890_x_at | -0.0392 | 0.8287 | |
| GSE77861 | KIR2DL1 | 3802 | 210890_x_at | 0.0821 | 0.5898 | |
| TCGA | KIR2DL1 | 3802 | RNAseq | 1.8425 | 0.1172 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KIR2DL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KIR2DL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KIR2DL1 | 3802 | 3 | 4 | 23 | |
| GSE20123 | KIR2DL1 | 3802 | 3 | 3 | 24 | |
| GSE43470 | KIR2DL1 | 3802 | 3 | 11 | 29 | |
| GSE46452 | KIR2DL1 | 3802 | 45 | 1 | 13 | |
| GSE47630 | KIR2DL1 | 3802 | 8 | 6 | 26 | |
| GSE54993 | KIR2DL1 | 3802 | 17 | 4 | 49 | |
| GSE54994 | KIR2DL1 | 3802 | 4 | 13 | 36 | |
| GSE60625 | KIR2DL1 | 3802 | 9 | 0 | 2 | |
| GSE74703 | KIR2DL1 | 3802 | 3 | 7 | 26 | |
| GSE74704 | KIR2DL1 | 3802 | 3 | 1 | 16 | |
| TCGA | KIR2DL1 | 3802 | 19 | 14 | 63 |
Total number of gains: 117; Total number of losses: 64; Total Number of normals: 307.
Somatic mutations of KIR2DL1:
Generating mutation plots.
Highly correlated genes for KIR2DL1:
Showing top 20/575 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KIR2DL1 | GPA33 | 0.720144 | 5 | 0 | 5 |
| KIR2DL1 | NXPE4 | 0.703294 | 4 | 0 | 4 |
| KIR2DL1 | KIR2DL2 | 0.698713 | 7 | 0 | 6 |
| KIR2DL1 | TCL6 | 0.681862 | 3 | 0 | 3 |
| KIR2DL1 | CCDC38 | 0.68106 | 3 | 0 | 3 |
| KIR2DL1 | DAB1 | 0.67909 | 4 | 0 | 4 |
| KIR2DL1 | KIR2DL5A | 0.67717 | 8 | 0 | 8 |
| KIR2DL1 | SCN10A | 0.674548 | 3 | 0 | 3 |
| KIR2DL1 | NAA11 | 0.666968 | 3 | 0 | 3 |
| KIR2DL1 | ERN1 | 0.656496 | 3 | 0 | 3 |
| KIR2DL1 | DNAJA4 | 0.655257 | 4 | 0 | 4 |
| KIR2DL1 | ARVCF | 0.654506 | 5 | 0 | 4 |
| KIR2DL1 | CYP3A4 | 0.653903 | 5 | 0 | 4 |
| KIR2DL1 | NRP2 | 0.653398 | 3 | 0 | 3 |
| KIR2DL1 | ADAMTS6 | 0.651752 | 3 | 0 | 3 |
| KIR2DL1 | CAMK2B | 0.64873 | 6 | 0 | 5 |
| KIR2DL1 | ADAMTS12 | 0.647688 | 5 | 0 | 5 |
| KIR2DL1 | EPHA5 | 0.647331 | 3 | 0 | 3 |
| KIR2DL1 | CHRM5 | 0.646886 | 7 | 0 | 6 |
| KIR2DL1 | GABRB2 | 0.646177 | 5 | 0 | 5 |
For details and further investigation, click here
