| Full name: melanocortin 4 receptor | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 18q21.32 | ||
| Entrez ID: 4160 | HGNC ID: HGNC:6932 | Ensembl Gene: ENSG00000166603 | OMIM ID: 155541 |
| Drug and gene relationship at DGIdb | |||
Expression of MC4R:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MC4R | 4160 | 221467_at | -0.1632 | 0.8254 | |
| GSE20347 | MC4R | 4160 | 221467_at | 0.0252 | 0.7656 | |
| GSE23400 | MC4R | 4160 | 221467_at | -0.1154 | 0.0007 | |
| GSE26886 | MC4R | 4160 | 221467_at | -0.0542 | 0.6748 | |
| GSE29001 | MC4R | 4160 | 221467_at | -0.0775 | 0.5994 | |
| GSE38129 | MC4R | 4160 | 221467_at | -0.0571 | 0.5645 | |
| GSE45670 | MC4R | 4160 | 221467_at | 0.1871 | 0.0925 | |
| GSE53622 | MC4R | 4160 | 55730 | -0.4388 | 0.0006 | |
| GSE53624 | MC4R | 4160 | 55730 | -0.5031 | 0.0000 | |
| GSE63941 | MC4R | 4160 | 221467_at | 0.0727 | 0.7056 | |
| GSE77861 | MC4R | 4160 | 221467_at | -0.1146 | 0.3142 | |
| TCGA | MC4R | 4160 | RNAseq | -0.2677 | 0.7922 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MC4R expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MC4R:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MC4R | 4160 | 1 | 9 | 20 | |
| GSE20123 | MC4R | 4160 | 1 | 9 | 20 | |
| GSE43470 | MC4R | 4160 | 0 | 5 | 38 | |
| GSE46452 | MC4R | 4160 | 1 | 26 | 32 | |
| GSE47630 | MC4R | 4160 | 5 | 20 | 15 | |
| GSE54993 | MC4R | 4160 | 10 | 0 | 60 | |
| GSE54994 | MC4R | 4160 | 1 | 17 | 35 | |
| GSE60625 | MC4R | 4160 | 0 | 4 | 7 | |
| GSE74703 | MC4R | 4160 | 0 | 5 | 31 | |
| GSE74704 | MC4R | 4160 | 1 | 6 | 13 | |
| TCGA | MC4R | 4160 | 9 | 44 | 43 |
Total number of gains: 29; Total number of losses: 145; Total Number of normals: 314.
Somatic mutations of MC4R:
Generating mutation plots.
Highly correlated genes for MC4R:
Showing top 20/624 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MC4R | KRT38 | 0.711855 | 3 | 0 | 3 |
| MC4R | CCDC87 | 0.695515 | 4 | 0 | 4 |
| MC4R | BPIFA1 | 0.689799 | 4 | 0 | 4 |
| MC4R | SCN10A | 0.685967 | 3 | 0 | 3 |
| MC4R | CER1 | 0.682206 | 5 | 0 | 5 |
| MC4R | GPLD1 | 0.681767 | 3 | 0 | 3 |
| MC4R | KCNJ3 | 0.677154 | 3 | 0 | 3 |
| MC4R | GRPR | 0.676188 | 4 | 0 | 4 |
| MC4R | ESRRG | 0.675899 | 3 | 0 | 3 |
| MC4R | ZNF611 | 0.674838 | 3 | 0 | 3 |
| MC4R | RNF17 | 0.670611 | 4 | 0 | 4 |
| MC4R | GPD1 | 0.66665 | 4 | 0 | 4 |
| MC4R | CIITA | 0.66562 | 5 | 0 | 5 |
| MC4R | KHDRBS2 | 0.665292 | 5 | 0 | 4 |
| MC4R | KCNJ10 | 0.664291 | 4 | 0 | 4 |
| MC4R | IFNA17 | 0.66284 | 5 | 0 | 5 |
| MC4R | PSG9 | 0.662717 | 3 | 0 | 3 |
| MC4R | SYP | 0.661816 | 4 | 0 | 3 |
| MC4R | CHGA | 0.660688 | 3 | 0 | 3 |
| MC4R | HHLA1 | 0.660426 | 5 | 0 | 5 |
For details and further investigation, click here
