| Full name: sodium voltage-gated channel alpha subunit 5 | Alias Symbol: Nav1.5|LQT3|HB1|HBBD|PFHB1|IVF|HB2|HH1|SSS1|CDCD2|CMPD2|ICCD | ||
| Type: protein-coding gene | Cytoband: 3p22.2 | ||
| Entrez ID: 6331 | HGNC ID: HGNC:10593 | Ensembl Gene: ENSG00000183873 | OMIM ID: 600163 |
| Drug and gene relationship at DGIdb | |||
SCN5A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04261 | Adrenergic signaling in cardiomyocytes |
Expression of SCN5A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCN5A | 6331 | 207413_s_at | -0.0419 | 0.9074 | |
| GSE20347 | SCN5A | 6331 | 207413_s_at | -0.0262 | 0.6507 | |
| GSE23400 | SCN5A | 6331 | 207413_s_at | -0.0336 | 0.3406 | |
| GSE26886 | SCN5A | 6331 | 207413_s_at | 0.4605 | 0.0863 | |
| GSE29001 | SCN5A | 6331 | 207413_s_at | -0.1253 | 0.4687 | |
| GSE38129 | SCN5A | 6331 | 207413_s_at | -0.0822 | 0.1878 | |
| GSE45670 | SCN5A | 6331 | 207413_s_at | 0.0122 | 0.9142 | |
| GSE53622 | SCN5A | 6331 | 54855 | 0.2697 | 0.0007 | |
| GSE53624 | SCN5A | 6331 | 10755 | -3.0200 | 0.0000 | |
| GSE63941 | SCN5A | 6331 | 207413_s_at | 0.3043 | 0.2721 | |
| GSE77861 | SCN5A | 6331 | 207413_s_at | -0.0794 | 0.4462 | |
| GSE97050 | SCN5A | 6331 | A_33_P3350547 | -0.1774 | 0.7252 | |
| SRP133303 | SCN5A | 6331 | RNAseq | -0.3907 | 0.2328 | |
| SRP159526 | SCN5A | 6331 | RNAseq | 0.6655 | 0.3054 | |
| TCGA | SCN5A | 6331 | RNAseq | -0.2320 | 0.5594 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SCN5A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCN5A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCN5A | 6331 | 0 | 19 | 11 | |
| GSE20123 | SCN5A | 6331 | 0 | 19 | 11 | |
| GSE43470 | SCN5A | 6331 | 0 | 20 | 23 | |
| GSE46452 | SCN5A | 6331 | 2 | 17 | 40 | |
| GSE47630 | SCN5A | 6331 | 1 | 25 | 14 | |
| GSE54993 | SCN5A | 6331 | 7 | 2 | 61 | |
| GSE54994 | SCN5A | 6331 | 0 | 34 | 19 | |
| GSE60625 | SCN5A | 6331 | 5 | 0 | 6 | |
| GSE74703 | SCN5A | 6331 | 0 | 16 | 20 | |
| GSE74704 | SCN5A | 6331 | 0 | 13 | 7 | |
| TCGA | SCN5A | 6331 | 1 | 71 | 24 |
Total number of gains: 16; Total number of losses: 236; Total Number of normals: 236.
Somatic mutations of SCN5A:
Generating mutation plots.
Highly correlated genes for SCN5A:
Showing top 20/266 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCN5A | LYG1 | 0.742105 | 3 | 0 | 3 |
| SCN5A | PGC | 0.734586 | 3 | 0 | 3 |
| SCN5A | CIB3 | 0.73449 | 3 | 0 | 3 |
| SCN5A | LIME1 | 0.733166 | 4 | 0 | 4 |
| SCN5A | TGM6 | 0.717106 | 3 | 0 | 3 |
| SCN5A | TATDN3 | 0.712245 | 3 | 0 | 3 |
| SCN5A | ZNF527 | 0.711745 | 4 | 0 | 4 |
| SCN5A | STAC2 | 0.711208 | 4 | 0 | 3 |
| SCN5A | ADH6 | 0.709135 | 4 | 0 | 3 |
| SCN5A | LRRC30 | 0.707554 | 3 | 0 | 3 |
| SCN5A | ZCCHC18 | 0.704967 | 3 | 0 | 3 |
| SCN5A | ENPP1 | 0.70472 | 3 | 0 | 3 |
| SCN5A | SLC22A25 | 0.694727 | 3 | 0 | 3 |
| SCN5A | DEFB128 | 0.692103 | 3 | 0 | 3 |
| SCN5A | GJD4 | 0.687213 | 3 | 0 | 3 |
| SCN5A | PAQR6 | 0.683878 | 4 | 0 | 4 |
| SCN5A | USP51 | 0.6821 | 4 | 0 | 4 |
| SCN5A | U2AF1L4 | 0.680484 | 3 | 0 | 3 |
| SCN5A | OR2Z1 | 0.679406 | 3 | 0 | 3 |
| SCN5A | ST8SIA3 | 0.666946 | 4 | 0 | 4 |
For details and further investigation, click here
