| Full name: semaphorin 3D | Alias Symbol: coll-2|Sema-Z2 | ||
| Type: protein-coding gene | Cytoband: 7q21.11 | ||
| Entrez ID: 223117 | HGNC ID: HGNC:10726 | Ensembl Gene: ENSG00000153993 | OMIM ID: 609907 |
| Drug and gene relationship at DGIdb | |||
SEMA3D involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of SEMA3D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEMA3D | 223117 | 215324_at | -0.0573 | 0.8123 | |
| GSE20347 | SEMA3D | 223117 | 215324_at | 0.0521 | 0.3733 | |
| GSE23400 | SEMA3D | 223117 | 215324_at | -0.0531 | 0.0033 | |
| GSE26886 | SEMA3D | 223117 | 215324_at | 0.1548 | 0.1714 | |
| GSE29001 | SEMA3D | 223117 | 215324_at | 0.0236 | 0.8394 | |
| GSE38129 | SEMA3D | 223117 | 215324_at | 0.0393 | 0.4152 | |
| GSE45670 | SEMA3D | 223117 | 215643_at | 0.4238 | 0.2487 | |
| GSE53622 | SEMA3D | 223117 | 28532 | 0.6019 | 0.0070 | |
| GSE53624 | SEMA3D | 223117 | 28532 | 0.9929 | 0.0000 | |
| GSE63941 | SEMA3D | 223117 | 215324_at | 0.0320 | 0.9065 | |
| GSE77861 | SEMA3D | 223117 | 215324_at | 0.0118 | 0.9302 | |
| GSE97050 | SEMA3D | 223117 | A_32_P29118 | 0.1560 | 0.4438 | |
| SRP007169 | SEMA3D | 223117 | RNAseq | 4.0841 | 0.0000 | |
| SRP133303 | SEMA3D | 223117 | RNAseq | 1.4153 | 0.0015 | |
| SRP159526 | SEMA3D | 223117 | RNAseq | 2.3034 | 0.0017 | |
| SRP219564 | SEMA3D | 223117 | RNAseq | 2.0324 | 0.0521 | |
| TCGA | SEMA3D | 223117 | RNAseq | -0.1897 | 0.5362 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by SEMA3D expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEMA3D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEMA3D | 223117 | 12 | 1 | 17 | |
| GSE20123 | SEMA3D | 223117 | 11 | 1 | 18 | |
| GSE43470 | SEMA3D | 223117 | 4 | 1 | 38 | |
| GSE46452 | SEMA3D | 223117 | 12 | 0 | 47 | |
| GSE47630 | SEMA3D | 223117 | 7 | 3 | 30 | |
| GSE54993 | SEMA3D | 223117 | 1 | 7 | 62 | |
| GSE54994 | SEMA3D | 223117 | 16 | 3 | 34 | |
| GSE60625 | SEMA3D | 223117 | 0 | 0 | 11 | |
| GSE74703 | SEMA3D | 223117 | 3 | 1 | 32 | |
| GSE74704 | SEMA3D | 223117 | 7 | 1 | 12 | |
| TCGA | SEMA3D | 223117 | 48 | 6 | 42 |
Total number of gains: 121; Total number of losses: 24; Total Number of normals: 343.
Somatic mutations of SEMA3D:
Generating mutation plots.
Highly correlated genes for SEMA3D:
Showing top 20/127 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEMA3D | HUNK | 0.685101 | 3 | 0 | 3 |
| SEMA3D | ZNF358 | 0.674591 | 3 | 0 | 3 |
| SEMA3D | DAGLA | 0.664414 | 3 | 0 | 3 |
| SEMA3D | CHD5 | 0.660022 | 5 | 0 | 5 |
| SEMA3D | IGSF1 | 0.65667 | 4 | 0 | 4 |
| SEMA3D | SLC6A5 | 0.638981 | 4 | 0 | 4 |
| SEMA3D | OCLM | 0.632424 | 3 | 0 | 3 |
| SEMA3D | FAM153A | 0.630402 | 3 | 0 | 3 |
| SEMA3D | DEFA4 | 0.628053 | 3 | 0 | 3 |
| SEMA3D | GP9 | 0.62159 | 3 | 0 | 3 |
| SEMA3D | IZUMO4 | 0.620809 | 4 | 0 | 3 |
| SEMA3D | OR3A2 | 0.619179 | 4 | 0 | 4 |
| SEMA3D | CDH15 | 0.61843 | 4 | 0 | 4 |
| SEMA3D | RIBC1 | 0.617421 | 3 | 0 | 3 |
| SEMA3D | NKX6-2 | 0.615401 | 3 | 0 | 3 |
| SEMA3D | PDCD1 | 0.613266 | 3 | 0 | 3 |
| SEMA3D | PWAR5 | 0.612865 | 3 | 0 | 3 |
| SEMA3D | LINC01118 | 0.611034 | 3 | 0 | 3 |
| SEMA3D | FRS3 | 0.606558 | 4 | 0 | 3 |
| SEMA3D | OR2W1 | 0.601699 | 4 | 0 | 3 |
For details and further investigation, click here
